Strain Data Sheet

RBRC01888

update : 2023-05-22

Information1
Image
BRC No.	RBRC01888
Type	Spontaneous Mutation Congenic
Species	Mus musculus
Strain name	C57BL/6-W<sh>/W<sh>
Former Common name	W sash, C57BL/6-W<sh>
H-2 Haplotype
ES Cell line
Background strain	C57BL/6J
Appearance	white, black eyes [a/a B/B C/C Sh/Sh] black [a/a B/B C/C +/+] black with white spotting [a/a B/B C/C Sh/+]
Strain development	Developed by Keisuke Oboki, RIKEN Research Center for Allergy anf Immunology. This strain was generated by backcrossing to C57BL/6 from C;B6-a/a-b/b-W<sh>/W<sh> strain (RBRC00762).
Strain description	The Kit<W-sh> mutation arose spontaneously in the (C3H/HeN x 101/H)F1 at the MRC (Lyon et al., 1982). Homozygous mice are white coat with black eyes. Heterozygotes are black with a white sash. This strain is useful for study of melanogenesis and neural crest migration.
Colony maintenance	Heteryozygote x Homozygote. Homozygous mutant mice are viable and fertile.
References	Am. J. Pathal., 167, 835-848 (2005). 16127161 Genet. Res., 39, 315-322 (1982). 7117838 Development, 118, 705-717 (1993). 7521281 Blood, 94, 2658-2666 (1999). 10515869 Blood, 83, 3509-3516 (1994). 7515715 Blood, 80, 1448-1453 (1992). 1381627

Health Report
Examination Date / Room / Rack	2023/03/13Room:3-6Rack:A 2022/12/12Room:3-6Rack:A 2022/09/12Room:3-6Rack:A 2022/06/13Room:3-6Rack:A 2022/03/14Room:3-6Rack:A 2021/12/14Room:3-6Rack:A 2021/09/13Room:3-6Rack:A 2021/06/14Room:3-6Rack:A

Gene
Gene info	Gene symbolGene nameChr.Allele symbolAllele nameCommon namesPromoter Kitkit oncogene5Kit<W-Sh>sashbelly-spot, c-KIT, CD117, Dominant white spotting, Steel Factor Receptor, Tr-kit

Information2
Donor DNA
Research application	Dermatology Research Immunology and Inflammation Research
Specific Term and Conditions	No specific terms and conditions. (The DEPOSITOR waives its own rights under any patents, intellectual property, or other proprietary rights with respect to the results to be obtained by use of the BIOLOGICAL RESOURCE.)
Depositor	Keisuke Oboki (RIKEN)
Strain Status	Live mice Frozen embryos Frozen sperm
Strain Availability	Cryopreserved sperm (within 1 month) Cryopreserved embryos (within 1 month) Live mouse (1 to 3 months)
Additional Info.	Genetic Background Necessary documents for ordering: Order form (Japanese / English) Category I MTA: MTA for distribution with RIKEN BRC (Japanese / English) Genotyping protocol -PCR-

BRC mice in Publications

Iwanaga K, Nakamura T, Maeda S, Aritake K, Hori M, Urade Y, Ozaki H, Murata T. Mast cell-derived prostaglandin D2 inhibits colitis and colitis-associated colon cancer in mice. Cancer Res 74(11) 3011-9(2014) 24879565 Schuler P, Contassot E, Irla M, Hugues S, Preynat-Seauve O, Beermann F, Donda A, French LE, Huard B. Direct presentation of a melanocyte-associated antigen in peripheral lymph nodes induces cytotoxic CD8+ T cells. Cancer Res 68(20) 8410-8(2008) 18922914 Murata A, Hikosaka M, Yoshino M, Zhou L, Hayashi SI. Kit-independent mast cell adhesion mediated by Notch. Int Immunol 31(2) 69-79(2019) 30299470 Hitomi K, Tahara-Hanaoka S, Miki H, Iwata K, Shibayama S, Kubo M, Shibuya A. Allergin-1 on mast cells suppresses house dust mite-induced airway hyperresponsiveness in mice. Int Immunol 30(9) 429-434(2018) 30169732 Nakahashi-Oda C, Tahara-Hanaoka S, Shoji M, Okoshi Y, Nakano-Yokomizo T, Ohkohchi N, Yasui T, Kikutani H, Honda S, Shibuya K, Nagata S, Shibuya A. Apoptotic cells suppress mast cell inflammatory responses via the CD300a immunoreceptor. J Exp Med 209(8) 1493-503(2012) 22826299 Ohneda K, Moriguchi T, Ohmori S, Ishijima Y, Satoh H, Philipsen S, Yamamoto M. Transcription factor GATA1 is dispensable for mast cell differentiation in adult mice. Mol Cell Biol 34(10) 1812-26(2014) 24615013 Nakamura T, Maeda S, Horiguchi K, Maehara T, Aritake K, Choi BI, Iwakura Y, Urade Y, Murata T. PGD2 deficiency exacerbates food antigen-induced mast cell hyperplasia. Nat Commun 6 7514(2015) 26159556 Murata T, Aritake K, Matsumoto S, Kamauchi S, Nakagawa T, Hori M, Momotani E, Urade Y, Ozaki H. Prostagladin D2 is a mast cell-derived antiangiogenic factor in lung carcinoma. Proc Natl Acad Sci U S A 108(49) 19802-7(2011) 22106279

BRC mice in Publications

Iwanaga K, Nakamura T, Maeda S, Aritake K, Hori M, Urade Y, Ozaki H, Murata T.
Mast cell-derived prostaglandin D2 inhibits colitis and colitis-associated colon cancer in mice.
Cancer Res 74(11) 3011-9(2014) 24879565

Schuler P, Contassot E, Irla M, Hugues S, Preynat-Seauve O, Beermann F, Donda A, French LE, Huard B.
Direct presentation of a melanocyte-associated antigen in peripheral lymph nodes induces cytotoxic CD8+ T cells.
Cancer Res 68(20) 8410-8(2008) 18922914

Murata A, Hikosaka M, Yoshino M, Zhou L, Hayashi SI.
Kit-independent mast cell adhesion mediated by Notch.
Int Immunol 31(2) 69-79(2019) 30299470

Hitomi K, Tahara-Hanaoka S, Miki H, Iwata K, Shibayama S, Kubo M, Shibuya A.
Allergin-1 on mast cells suppresses house dust mite-induced airway hyperresponsiveness in mice.
Int Immunol 30(9) 429-434(2018) 30169732

Nakahashi-Oda C, Tahara-Hanaoka S, Shoji M, Okoshi Y, Nakano-Yokomizo T, Ohkohchi N, Yasui T, Kikutani H, Honda S, Shibuya K, Nagata S, Shibuya A.
Apoptotic cells suppress mast cell inflammatory responses via the CD300a immunoreceptor.
J Exp Med 209(8) 1493-503(2012) 22826299

Ohneda K, Moriguchi T, Ohmori S, Ishijima Y, Satoh H, Philipsen S, Yamamoto M.
Transcription factor GATA1 is dispensable for mast cell differentiation in adult mice.
Mol Cell Biol 34(10) 1812-26(2014) 24615013

Nakamura T, Maeda S, Horiguchi K, Maehara T, Aritake K, Choi BI, Iwakura Y, Urade Y, Murata T.
PGD2 deficiency exacerbates food antigen-induced mast cell hyperplasia.
Nat Commun 6 7514(2015) 26159556

Murata T, Aritake K, Matsumoto S, Kamauchi S, Nakagawa T, Hori M, Momotani E, Urade Y, Ozaki H.
Prostagladin D2 is a mast cell-derived antiangiogenic factor in lung carcinoma.
Proc Natl Acad Sci U S A 108(49) 19802-7(2011) 22106279

Information1

Health Report

Gene

Information2

BRC mice in Publications