Strain Information | |
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Image | |
BRC No. | RBRC01872 |
Type | Targeted Mutation |
Species | Mus musculus |
Strain name | FVB;129P2(Cg)-Apc<tm2.1Cip>/GvnRbrc |
Former Common name | ApcFlox14 |
H-2 Haplotype | |
ES Cell line | |
Background strain | |
Appearance | albino [A/A B/B c/c D/D P/P] |
Strain development | Developed by Dr. Marco Giovannini, INSERM France. |
Strain description | 大腸腺腫症遺伝子Apc, adenomatosis polyposis coli遺伝子のfloxedマウス。creマウスとの交配により組織特異的にノックアウトマウスを作成可能。エクソン14がloxPで挟まれている。 |
Colony maintenance | Sibling Mating (Homozygote x Homozygote) |
References | Lab Invest., 84, 1619-1930 (2004). 15502862 Proc. Natl. Acad. Sci. USA, 101, 17216-17221 (2004). 15563600 |
Health Report | |
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Examination Date / Room / Rack |
Gene | |
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Gene info | Gene symbolGene nameChr.Allele symbolAllele nameCommon namesPromoter Gene symbolGene nameChr.Allele symbolAllele nameCommon namesPromoter loxPphage P1 loxP18loxP Gene symbolGene nameChr.Allele symbolAllele nameCommon namesPromoter loxPphage P1 loxP18loxP |
Ordering Information | |
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供与核酸 | Phage P1 loxP sites, mouse Apc genomic DNA |
Research application | Cre/loxP system |
提供条件 | 条件を付加する。 研究成果の公表にあたって寄託者の指定する文献を引用する。Proc. Natl. Acad. Sci., 101, 17216-17221 (2004). Lab Invest., 84, 1619-1930 (2004). 研究成果の公表にあたって謝辞の表明を必要とする。 RECIPIENT shall keep DEPOSITOR apprised of any results obtained from the BIOLOGICAL RESOURCE in the course of the research, as soon as they are available. Moreover, if the research results in a potential invention or a substance that may have potential commercial value (hereinafter referred as to the "Invention") RECIPIENT will promptly disclose this Invention to DEPOSITOR with samples thereof for DEPOSITOR's internal use. RECIPIENT and DEPOSITOR will consult together and agree about the possibility of filing one or more patent application to Invention conceived by one or more employees of Recipients that directly arise out of the research. The Parties will negotiate in good faith the conditions of such patent application according to each party's inventiveness contribution in the Invention. In case of such Invention, patentable or not, reduced in practice or developed in the course of the research that could not have been obtained, reduced to practice or developed but from using the Material and/or Confidential Information, RECIPIENT and DEPOSITOR shall confer with one another as regards licensing and commercialization of such Invention to negotiate in good faith the terms of an institutional agreement as regards said matters. |
Depositor | Marco Giovannini(INSERM) |
Strain Status | 凍結胚 |
Strain Availability | 凍結胚より作出したマウスを2~4ヶ月以内に提供可能 凍結胚を1ヶ月以内に提供可能 |
Additional Info. | Necessary documents for ordering:
Genotyping protocol -PCR- |
BRC mice in Publications |
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Nakata T, Shimizu H, Nagata S, Ito G, Fujii S, Suzuki K, Kawamoto A, Ishibashi F, Kuno R, Anzai S, Murano T, Mizutani T, Oshima S, Tsuchiya K, Nakamura T, Hozumi K, Watanabe M, Okamoto R. Indispensable role of Notch ligand-dependent signaling in the proliferation and stem cell niche maintenance of APC-deficient intestinal tumors. Biochem Biophys Res Commun 482(4) 1296-1303(2017) 27939883 Funato Y, Yamazaki D, Mizukami S, Du L, Kikuchi K, Miki H. Membrane protein CNNM4-dependent Mg2+ efflux suppresses tumor progression. J Clin Invest 124(12) 5398-410(2014) 25347473 Ishibashi F, Shimizu H, Nakata T, Fujii S, Suzuki K, Kawamoto A, Anzai S, Kuno R, Nagata S, Ito G, Murano T, Mizutani T, Oshima S, Tsuchiya K, Nakamura T, Watanabe M, Okamoto R. Contribution of ATOH1+ Cells to the Homeostasis, Repair, and Tumorigenesis of the Colonic Epithelium. Stem Cell Reports 10(1) 27-42(2018) 29233556 |