Strain Information | |
---|---|
Image | |
BRC No. | RBRC01869 |
Type | Targeted Mutation |
Species | Mus musculus |
Strain name | B6.129-Nod2<tm1Jhgt> |
Former Common name | Card15 KO (C57BL/6N background) |
H-2 Haplotype | |
ES Cell line | |
Background strain | |
Appearance | |
Strain development | INSERM・Marco Giovannini。PGK-hygromycinカセットは除去済み。 |
Strain description | Card15 (Nod2) 遺伝子のノックアウトマウス。エクソン1をEGFPカセットで置換。GFPの発現は低い。C57BL/6背景 (RBRC01869) 、C57BL/6と129混合背景 (RBRC01941) 。 |
Colony maintenance | Homozygote x Homozygote |
References | PLoS One, 2(6), e523 (2007). 17565376 |
Health Report | |
---|---|
Examination Date / Room / Rack |
Gene | |
---|---|
Gene info | Gene symbolGene nameChr.Allele symbolAllele nameCommon namesPromoter Gene symbolGene nameChr.Allele symbolAllele nameCommon namesPromoter EGFPEnhanced Green Fluorescent Protein (Aequorea victoria)8EGFP Gene symbolGene nameChr.Allele symbolAllele nameCommon namesPromoter loxPphage P1 loxP8loxP |
Ordering Information | |
---|---|
供与核酸 | jellyfish EGFP cDNA, SV40 polyA, Phage P1 loxP site, mouse Nod2 genomic DNA |
Research application | Cre/loxP system Fluorescent Proteins/lacZ System Immunology and Inflammation Research Internal/Organ Research Mouse Models for Human Disease |
提供条件 | 条件を付加する。 研究成果の公表にあたって謝辞の表明を必要とする。 RECIPIENT shall keep DEPOSITOR apprised of any results obtained from the BIOLOGICAL RESOURCE in the course of the research, as soon as they are available. Moreover, if the research results in a potential invention or a substance that may have potential commercial value (hereinafter referred as to the "Invention") RECIPIENT will promptly disclose this Invention to DEPOSITOR with samples thereof for DEPOSITOR's internal use. RECIPIENT and DEPOSITOR will consult together and agree about the possibility of filing one or more patent application to Invention conceived by one or more employees of Recipients that directly arise out of the research. The Parties will negotiate in good faith the conditions of such patent application according to each party's inventiveness contribution in the Invention. In case of such Invention, patentable or not, reduced in practice or developed in the course of the research that could not have been obtained, reduced to practice or developed but from using the Material and/or Confidential Information, RECIPIENT and DEPOSITOR shall confer with one another as regards licensing and commercialization of such Invention to negotiate in good faith the terms of an institutional agreement as regards said matters. |
Depositor | Marco Giovannini(INSERM) |
Strain Status | 凍結胚 |
Strain Availability | 凍結胚より作出したマウスを2~4ヶ月以内に提供可能 凍結胚を1ヶ月以内に提供可能 |
Additional Info. | Necessary documents for ordering:
Genotyping protocol -PCR- Mouse of the Month Jun 2007 |
BRC mice in Publications |
---|
Zong J, Salim M, Zhou H, Bian ZY, Dai J, Yuan Y, Deng W, Zhang JY, Zhang R, Wu QQ, Tang QZ. NOD2 deletion promotes cardiac hypertrophy and fibrosis induced by pressure overload. Lab Invest 93(10) 1128-36(2013) 23958879 |