Strain Data Sheet

Nakashiba T, Sugiyama T, Iwano S, Iwama M, Yoshiki A, Miyawaki A, Abe K.
Assessing leaky expression of Cre-dependent DNA constructs in the mouse genome using sensitive bioluminescent reporters.
Cell Rep Methods 101369(2026) 41916303

Horike N, Oura S, Koyamatsu S, Tanaka N, Iimori Y, Fujita K, Nemoto T, Ikawa M, Tsumaki N.
Excess FGFR3 signaling in achondroplasia disrupts turnover of resting zone chondrocytes via CREB signaling.
Nat Commun 17(1) (2026) 41748604

Liu X, Jiang Z, Otani Y, Zhu X, Yu Y, Tarif AMM, Ferdousy RN, Kishino T, Fujitani M.
UBE3A controls axon initial segment in the cortical pyramidal neurons.
Biochem Biophys Res Commun 751 151429(2025) 39914145

Terakawa J, Nakamura S, Ohtomo M, Uehara S, Kawata Y, Takarabe S, Sugita H, Namiki T, Kageyama A, Noguchi M, Murakami H, Kashiwazaki N, Ito J.
LIFR-Mediated ERBB2 Signaling Is Essential for Successful Embryo Implantation in Mice.
Biomolecules 15(5) (2025) 40427591

Nakata Y, Ueda T, Sera Y, Koizumi M, Imamura K, Kanai A, Ikeda KI, Yamasaki N, Nagamachi A, Kobatake K, Taguchi M, Sotomaru Y, Ichinohe T, Honda ZI, Nakamura T, Manabe I, Suda T, Takubo K, Kaminuma O, Honda H.
JMJD3-mediated senescence is required to overcome stress-induced hematopoietic defects.
EMBO Rep 26(15) 3831-3855(2025) 40562791

Nozaki Y, Kobayashi M, Fukuoh T, Ishimatsu M, Narita T, Taki K, Hirao Y, Ayabe S, Yokoyama M, Otani Y, Mizunoe Y, Matsumoto M, Ohno N, Kaifu T, Okazaki S, Goitsuka R, Nakagawa Y, Shimano H, Iwakura Y, Higami Y.
Mipep deficiency in adipocytes impairs mitochondrial protein maturation and leads to systemic inflammation and metabolic dysfunctions.
Sci Rep 15(1) 12839(2025) 40229443

Shu J, Terakawa J, Takikawa S, Osuka S, Muraoka A, Ruan J, Iida A, Ito J, Hondo E.
RO8191, a new compound for initiating embryo implantation in mice.
Sci Rep 15(1) 32387(2025) 40925951

Trsan T, Peng V, Krishna C, Ohara TE, Beatty WL, Sudan R, Kanai M, Krishnamoorthy P, Rodrigues PF, Fachi JL, Grajales-Reyes G, Jaeger N, Fitzpatrick JAJ, Cella M, Gilfillan S, Nakata T, Jaiswal A, Stappenbeck TS, Daly MJ, Xavier RJ, Colonna M.
The centrosomal protein FGFR1OP controls myosin function in murine intestinal epithelial cells.
Dev Cell 59(18) 2460-2476.e10(2024) 38942017

Morikawa K, Nagasaki A, Sun L, Kawase E, Ebihara T, Shirayoshi Y.
Optogenetic control of early embryos labeling using photoactivatable Cre recombinase 3.0.
FEBS Open Bio 14(11) 1888-1898(2024) 39223831

Uota A, Okuno Y, Fukuhara A, Sasaki S, Kobayashi S, Shimomura I.
ARMC5 selectively degrades SCAP-free SREBF1 and is essential for fatty acid desaturation in adipocytes.
J Biol Chem 300(12) 107953(2024) 39491648

Fujinuma S, Nakatsumi H, Shimizu H, Sugiyama S, Harada A, Goya T, Tanaka M, Kohjima M, Takahashi M, Izumi Y, Yagi M, Kang D, Kaneko M, Shigeta M, Bamba T, Ohkawa Y, Nakayama KI.
FOXK1 promotes nonalcoholic fatty liver disease by mediating mTORC1-dependent inhibition of hepatic fatty acid oxidation.
Cell Rep 42(5) 112530(2023) 37209098

Takubo K, Htun PW, Ueda T, Sera Y, Iwasaki M, Koizumi M, Shiroshita K, Kobayashi H, Haraguchi M, Watanuki S, Honda ZI, Yamasaki N, Nakamura-Ishizu A, Arai F, Motoyama N, Hatta T, Natsume T, Suda T, Honda H.
MBTD1 preserves adult hematopoietic stem cell pool size and function.
Proc Natl Acad Sci U S A 120(32) e2206860120(2023) 37523546

Yamazaki S, Inohara N, Ohmuraya M, Tsuneoka Y, Yagita H, Katagiri T, Nishina T, Mikami T, Funato H, Araki K, Nakano H.
IκBζ controls IL-17-triggered gene expression program in intestinal epithelial cells that restricts colonization of SFB and prevents Th17-associated pathologies.
Mucosal Immunol 15(6) 1321-1337(2022) 35999460

Sasaki L, Hamada Y, Yarimizu D, Suzuki T, Nakamura H, Shimada A, Pham KTN, Shao X, Yamamura K, Inatomi T, Morinaga H, Nishimura EK, Kudo F, Manabe I, Haraguchi S, Sugiura Y, Suematsu M, Kinoshita S, Machida M, Nakajima T, Kiyonari H, Okamura H, Yamaguchi Y, Miyake T, Doi M.
Intracrine activity involving NAD-dependent circadian steroidogenic activity governs age-associated meibomian gland dysfunction.
Nat Aging 2(2) 105-114(2022) 37117756

Sera Y, Nakata Y, Ueda T, Yamasaki N, Koide S, Kobayashi H, Ikeda KI, Kobatake K, Iwasaki M, Oda H, Wolff L, Kanai A, Nagamachi A, Inaba T, Sotomaru Y, Ichinohe T, Koizumi M, Miyakawa Y, Honda ZI, Iwama A, Suda T, Takubo K, Honda H.
UTX maintains the functional integrity of the murine hematopoietic system by globally regulating aging-associated genes.
Blood 137(7) 908-922(2021) 33174606

Koga Y, Tsuchimoto D, Hayashi Y, Abolhassani N, Yoneshima Y, Sakumi K, Nakanishi H, Toyokuni S, Nakabeppu Y.
Neural stem cell-specific ITPA deficiency causes neural depolarization and epilepsy.
JCI Insight 5(22) (2020) 33208550

Wada Y, Kikuchi A, Kaga A, Shimizu N, Ito J, Onuma R, Fujishima F, Totsune E, Sato R, Niihori T, Shirota M, Funayama R, Sato K, Nakazawa T, Nakayama K, Aoki Y, Aiba S, Nakagawa K, Kure S.
Metabolic and pathologic profiles of human LSS deficiency recapitulated in mice.
PLoS Genet 16(2) e1008628(2020) 32101538

Kawara A, Mizuta R, Fujisawa M, Ito T, Li C, Nakamura K, Sun C, Kuwabara M, Kitabatake M, Yoshimura T, Matsukawa A.
Spred2-deficiency enhances the proliferation of lung epithelial cells and alleviates pulmonary fibrosis induced by bleomycin.
Sci Rep 10(1) 16490(2020) 33020583

Sakata D, Uruno T, Matsubara K, Andoh T, Yamamura K, Magoshi Y, Kunimura K, Kamikaseda Y, Furue M, Fukui Y.
Selective role of neurokinin B in IL-31-induced itch response in mice.
J Allergy Clin Immunol 144(4) 1130-1133.e8(2019) 31405606

Kawabata Galbraith K, Fujishima K, Mizuno H, Lee SJ, Uemura T, Sakimura K, Mishina M, Watanabe N, Kengaku M.
MTSS1 Regulation of Actin-Nucleating Formin DAAM1 in Dendritic Filopodia Determines Final Dendritic Configuration of Purkinje Cells.
Cell Rep 24(1) 95-106.e9(2018) 29972794

Inoue R, Abdou K, Hayashi-Tanaka A, Muramatsu SI, Mino K, Inokuchi K, Mori H.
Glucocorticoid receptor-mediated amygdalar metaplasticity underlies adaptive modulation of fear memory by stress.
Elife 7 (2018) 29941090

Takagi H, Ikehara T, Kashiwagi Y, Hashimoto K, Nanchi I, Shimazaki A, Nambu H, Yukioka H.
ACC2 Deletion Enhances IMCL Reduction Along With Acetyl-CoA Metabolism and Improves Insulin Sensitivity in Male Mice.
Endocrinology 159(8) 3007-3019(2018) 29931154

Kaitsuka T, Kiyonari H, Shiraishi A, Tomizawa K, Matsushita M.
Deletion of Long Isoform of Eukaryotic Elongation Factor 1Bδ Leads to Audiogenic Seizures and Aversive Stimulus-Induced Long-Lasting Activity Suppression in Mice.
Front Mol Neurosci 11 358(2018) 30333725

Herndler-Brandstetter D, Ishigame H, Shinnakasu R, Plajer V, Stecher C, Zhao J, Lietzenmayer M, Kroehling L, Takumi A, Kometani K, Inoue T, Kluger Y, Kaech SM, Kurosaki T, Okada T, Flavell RA.
KLRG1+ Effector CD8+ T Cells Lose KLRG1, Differentiate into All Memory T Cell Lineages, and Convey Enhanced Protective Immunity.
Immunity 48(4) 716-729.e8(2018) 29625895

Tsunoda T, Doi K, Ishikura S, Luo H, Nishi K, Matsuzaki H, Koyanagi M, Tanaka Y, Okamura T, Shirasawa S.
Zfat expression in ZsGreen reporter gene knock‑in mice: Implications for a novel function of Zfat in definitive erythropoiesis.
Int J Mol Med 42(5) 2595-2603(2018) 30106088

Kiyozumi D, Taniguchi Y, Nakano I, Toga J, Yagi E, Hasuwa H, Ikawa M, Sekiguchi K.
Laminin γ1 C-terminal Glu to Gln mutation induces early postimplantation lethality.
Life Sci Alliance 1(5) e201800064(2018) 30456378

Kimura-Yoshida C, Mochida K, Nakaya MA, Mizutani T, Matsuo I.
Cytoplasmic localization of GRHL3 upon epidermal differentiation triggers cell shape change for epithelial morphogenesis.
Nat Commun 9(1) 4059(2018) 30283008

Kawai Y, Oda A, Kanai Y, Goitsuka R.
Germ cell-intrinsic requirement for the homeodomain transcription factor PKnox1/Prep1 in adult spermatogenesis.
PLoS One 13(1) e0190702(2018) 29293683

Yanagihara T, Tomino T, Uruno T, Fukui Y.
Thymic epithelial cell-specific deletion of Jmjd6 reduces Aire protein expression and exacerbates disease development in a mouse model of autoimmune diabetes.
Biochem Biophys Res Commun 489(1) 8-13(2017) 28546003

Nakata Y, Ueda T, Nagamachi A, Yamasaki N, Ikeda KI, Sera Y, Takubo K, Kanai A, Oda H, Sanada M, Ogawa S, Tsuji K, Ebihara Y, Wolff L, Honda ZI, Suda T, Inaba T, Honda H.
Acquired expression of CblQ367P in mice induces dysplastic myelopoiesis mimicking chronic myelomonocytic leukemia.
Blood 129(15) 2148-2160(2017) 28209720

Morooka N, Futaki S, Sato-Nishiuchi R, Nishino M, Totani Y, Shimono C, Nakano I, Nakajima H, Mochizuki N, Sekiguchi K.
Polydom Is an Extracellular Matrix Protein Involved in Lymphatic Vessel Remodeling.
Circ Res 120(8) 1276-1288(2017) 28179430

Ogino H, Hisanaga A, Kohno T, Kondo Y, Okumura K, Kamei T, Sato T, Asahara H, Tsuiji H, Fukata M, Hattori M.
Secreted Metalloproteinase ADAMTS-3 Inactivates Reelin.
J Neurosci 37(12) 3181-3191(2017) 28213441

Baldridge MT, Lee S, Brown JJ, McAllister N, Urbanek K, Dermody TS, Nice TJ, Virgin HW.
Expression of Ifnlr1 on Intestinal Epithelial Cells Is Critical to the Antiviral Effects of Interferon Lambda against Norovirus and Reovirus.
J Virol 91(7) (2017) 28077655

Ishikawa T, Kitaura Y, Kadota Y, Morishita Y, Ota M, Yamanaka F, Xu M, Ikawa M, Inoue N, Kawano F, Nakai N, Murakami T, Miura S, Hatazawa Y, Kamei Y, Shimomura Y.
Muscle-specific deletion of BDK amplifies loss of myofibrillar protein during protein undernutrition.
Sci Rep 7 39825(2017) 28051178

Zheng Y, Yamamoto S, Ishii Y, Sang Y, Hamashima T, Van De N, Nishizono H, Inoue R, Mori H, Sasahara M.
Glioma-Derived Platelet-Derived Growth Factor-BB Recruits Oligodendrocyte Progenitor Cells via Platelet-Derived Growth Factor Receptor-α and Remodels Cancer Stroma.
Am J Pathol 186(5) 1081-91(2016) 26945107

Sugimoto M, Shimizu Y, Zhao S, Ukon N, Nishijima K, Wakabayashi M, Yoshioka T, Higashino K, Numata Y, Okuda T, Tamaki N, Hanamatsu H, Igarashi Y, Kuge Y.
Characterization of the role of sphingomyelin synthase 2 in glucose metabolism in whole-body and peripheral tissues in mice.
Biochim Biophys Acta 1861(8 Pt A) 688-702(2016) 27151272

Ichise H, Hori A, Shiozawa S, Kondo S, Kanegae Y, Saito I, Ichise T, Yoshida N.
Establishment of a tamoxifen-inducible Cre-driver mouse strain for widespread and temporal genetic modification in adult mice.
Exp Anim 65(3) 231-44(2016) 26923756

Kai T, Tsukamoto Y, Hijiya N, Tokunaga A, Nakada C, Uchida T, Daa T, Iha H, Takahashi M, Nomura T, Sato F, Mimata H, Ikawa M, Seto M, Matsuura K, Moriyama M.
Kidney-specific knockout of Sav1 in the mouse promotes hyperproliferation of renal tubular epithelium through suppression of the Hippo pathway.
J Pathol 239(1) 97-108(2016) 26913567

Hattori K, Naguro I, Okabe K, Funatsu T, Furutani S, Takeda K, Ichijo H.
ASK1 signalling regulates brown and beige adipocyte function.
Nat Commun 7 11158(2016) 27045525

Ikeda K, Ueda T, Yamasaki N, Nakata Y, Sera Y, Nagamachi A, Miyama T, Kobayashi H, Takubo K, Kanai A, Oda H, Wolff L, Honda Z, Ichinohe T, Matsubara A, Suda T, Inaba T, Honda H.
Maintenance of the functional integrity of mouse hematopoiesis by EED and promotion of leukemogenesis by EED haploinsufficiency.
Sci Rep 6 29454(2016) 27432459

Kawakami E, Tokunaga A, Ozawa M, Sakamoto R, Yoshida N.
The histone demethylase Fbxl11/Kdm2a plays an essential role in embryonic development by repressing cell-cycle regulators.
Mech Dev 135 31-42(2015) 25463925

Raveney BJ, Oki S, Hohjoh H, Nakamura M, Sato W, Murata M, Yamamura T.
Eomesodermin-expressing T-helper cells are essential for chronic neuroinflammation.
Nat Commun 6 8437(2015) 26436530

Yoshioka K, Oda A, Notsu C, Ohtsuka T, Kawai Y, Suzuki S, Nakamura T, Mabuchi Y, Matsuzaki Y, Goitsuka R.
Loss of the Homeodomain Transcription Factor Prep1 Perturbs Adult Hematopoiesis in the Bone Marrow.
PLoS One 10(8) e0136107(2015) 26285139

Jackson MZ, Gruner KA, Qin C, Tourtellotte WG.
A neuron autonomous role for the familial dysautonomia gene ELP1 in sympathetic and sensory target tissue innervation.
Development 141(12) 2452-61(2014) 24917501

Nakahara R, Kawai Y, Oda A, Nishimura M, Murakami A, Azuma T, Kaifu T, Goitsuka R.
Generation of a Tlx1(CreER-Venus) knock-in mouse strain for the study of spleen development.
Genesis 52(11) 916-23(2014) 25283275

Yu YR, You LR, Yan YT, Chen CM.
Role of OVCA1/DPH1 in craniofacial abnormalities of Miller-Dieker syndrome.
Hum Mol Genet 23(21) 5579-96(2014) 24895408

Fumoto T, Takeshita S, Ito M, Ikeda K.
Physiological functions of osteoblast lineage and T cell-derived RANKL in bone homeostasis.
J Bone Miner Res 29(4) 830-42(2014) 24014480

Nagamachi A, Nakata Y, Ueda T, Yamasaki N, Ebihara Y, Tsuji K, Honda Z, Takubo K, Suda T, Oda H, Inaba T, Honda H.
Acquired deficiency of A20 results in rapid apoptosis, systemic inflammation, and abnormal hematopoietic stem cell function.
PLoS One 9(1) e87425(2014) 24498102

Okuma A, Hoshino K, Ohba T, Fukushi S, Aiba S, Akira S, Ono M, Kaisho T, Muta T.
Enhanced apoptosis by disruption of the STAT3-IκB-ζ signaling pathway in epithelial cells induces Sjögren's syndrome-like autoimmune disease.
Immunity 38(3) 450-60(2013) 23453632

Kaji T, Ishige A, Hikida M, Taka J, Hijikata A, Kubo M, Nagashima T, Takahashi Y, Kurosaki T, Okada M, Ohara O, Rajewsky K, Takemori T.
Distinct cellular pathways select germline-encoded and somatically mutated antibodies into immunological memory.
J Exp Med 209(11) 2079-97(2012) 23027924

Kimura-Ueki M, Oda Y, Oki J, Komi-Kuramochi A, Honda E, Asada M, Suzuki M, Imamura T.
Hair cycle resting phase is regulated by cyclic epithelial FGF18 signaling.
J Invest Dermatol 132(5) 1338-45(2012) 22297635

Maeda K, Kobayashi Y, Udagawa N, Uehara S, Ishihara A, Mizoguchi T, Kikuchi Y, Takada I, Kato S, Kani S, Nishita M, Marumo K, Martin TJ, Minami Y, Takahashi N.
Wnt5a-Ror2 signaling between osteoblast-lineage cells and osteoclast precursors enhances osteoclastogenesis.
Nat Med 18(3) 405-12(2012) 22344299

Hara T, Mimura K, Abe T, Shioi G, Seiki M, Sakamoto T.
Deletion of the Mint3/Apba3 gene in mice abrogates macrophage functions and increases resistance to lipopolysaccharide-induced septic shock.
J Biol Chem 286(37) 32542-51(2011) 21778228

Kobayashi N, Miyoshi S, Mikami T, Koyama H, Kitazawa M, Takeoka M, Sano K, Amano J, Isogai Z, Niida S, Oguri K, Okayama M, McDonald JA, Kimata K, Taniguchi S, Itano N.
Hyaluronan deficiency in tumor stroma impairs macrophage trafficking and tumor neovascularization.
Cancer Res 70(18) 7073-83(2010) 20823158

Nakata H, Hashimoto T, Seki Y, Mekada K, Obata Y, Yoshiki A.
Simultaneous detection of multiple transgenes for genetically-modified mouse strains.
Exp Anim 58(4) 437-42(2009) 19654444