Strain Data Sheet

Nakashiba T, Sugiyama T, Iwano S, Iwama M, Yoshiki A, Miyawaki A, Abe K.
Assessing leaky expression of Cre-dependent DNA constructs in the mouse genome using sensitive bioluminescent reporters.
Cell Rep Methods 101369(2026) 41916303

Nagata H, Nagayoshi Y, Chujo T, Kaneko H, Nishiguchi K, Kakizoe Y, Ijima H, Sakakida K, Masuda T, Ohtsuki S, Wei FY, Takahashi Y, Fukuda T, Jinnouchi H, Adachi Y, Yamamura R, Matsushita K, Adachi M, Yokoi H, Nakamura K, Nakazato H, Tomizawa K.
CDKAL1 dysfunction impairs lysine codon translation in podocytes and accelerates chronic kidney disease.
EMBO J (2026) 41904323

Hashiuchi E, Inaba Y, Sugimoto H, Kimura K, Watanabe H, Kajino M, Asahara SI, Kobayashi M, Kikuchi O, Hayashi Y, Horike SI, Daikoku T, Mieda M, Sakurai T, Sakai M, Matsumoto M, Kitamura T, Sato M, Ravnskjaer K, Kasuga M, Tanida M, Kuroda S, Inoue H.
Vagal activation inhibits insulin release through neuronal nitric oxide synthase in obese male mice.
Sci Signal 19(939) eadz8805(2026) 42189938

Yamada S, Ogawa H, Funato M, Kato M, Nakadate K, Mizukoshi T, Kawakami K, Kobayashi R, Horii T, Hatada I, Sakakibara SI.
Induction of MASH-like pathogenesis in the Nwd1-/- mouse liver.
Commun Biol 8(1) 348(2025) 40069352

Barés G, Beà A, Sancho-Balsells A, Valero JG, Aluja D, Inserte J, García-Carpi S, Miró-Casas E, Borràs-Pernas S, Hernández S, Martínez-Val A, Olsen JV, Tebar F, Cañas X, Comella JX, Pérez-Galán P, Ruiz-Meana M, Giralt A, Llovera M, Sanchis D.
Mammalian TatD DNase domain containing 1 (TATDN1) is a proteostasis-responsive gene with roles in ventricular structure and neuromuscular function.
FEBS J (2025) 40123200

Toyonaga K, Kishikawa S, Nagao JI, Iwanuma A, Iwai S, Tanaka Y.
Adaptor protein CARD9 is required for systemic host defense against Candida auris.
iScience 28(11) 113864(2025) 41362778

Deminami M, Hashimoto M, Takahashi H, Harada N, Minami Y, Kitakaze T, Masuda W, Takenaka S, Inui H, Yamaji R.
Androgens suppress the sialyltransferases ST3GAL1 and ST3GAL4 and modulate mucin 10 glycosylation in the submandibular gland, related to sex differences in commensal microbiota composition in mice.
Biosci Biotechnol Biochem (2024) 39572079

Nozawa A, Abe T, Niihori T, Ozeki M, Aoki Y, Ohnishi H.
Lymphatic endothelial cell-specific NRAS p.Q61R mutant embryos show abnormal lymphatic vessel morphogenesis.
Hum Mol Genet (2024) 38743908

Nakata Y, Nagasawa S, Sera Y, Yamasaki N, Kanai A, Kobatake K, Ueda T, Koizumi M, Manabe I, Kaminuma O, Honda H.
PTIP epigenetically regulates DNA damage-induced cell cycle arrest by upregulating PRDM1.
Sci Rep 14(1) 17987(2024) 39097652

Yamada S, Tokunaga A, Sakakibara SI.
Inka2 expression in smooth muscle cells and its involvement in cell migration.
Biochem Biophys Res Commun 643 55-60(2023) 36586159

Nomura M, Ohuchi M, Sakamoto Y, Kudo K, Yaku K, Soga T, Sugiura Y, Morita M, Hayashi K, Miyahara S, Sato T, Yamashita Y, Ito S, Kikuchi N, Sato I, Saito R, Yaegashi N, Fukuhara T, Yamada H, Shima H, Nakayama KI, Hirao A, Kawasaki K, Arai Y, Akamatsu S, Tanuma SI, Sato T, Nakagawa T, Tanuma N.
Niacin restriction with NAMPT-inhibition is synthetic lethal to neuroendocrine carcinoma.
Nat Commun 14(1) 8095(2023) 38092728

Tsuchikawa Y, Kamei N, Sanada Y, Nakamae T, Harada T, Imaizumi K, Akimoto T, Miyaki S, Adachi N.
Deficiency of MicroRNA-23-27-24 Clusters Exhibits the Impairment of Myelination in the Central Nervous System.
Neural Plast 2023 8938674(2023) 37006814

Yamaguchi Y, Maekawa Y, Kabashima K, Mizuno T, Tainaka M, Suzuki T, Dojo K, Tominaga T, Kuroiwa S, Masubuchi S, Doi M, Tominaga K, Kobayashi K, Yamagata S, Itoi K, Abe M, Schwartz WJ, Sakimura K, Okamura H.
An intact pituitary vasopressin system is critical for building a robust circadian clock in the suprachiasmatic nucleus.
Proc Natl Acad Sci U S A 120(43) e2308489120(2023) 37844254

Wang J, Maeda E, Tsujimura Y, Abe T, Kiyonari H, Kitaguchi T, Yokota H, Matsumoto T.
In situ FRET measurement of cellular tension using conventional confocal laser microscopy in newly established reporter mice expressing actinin tension sensor.
Sci Rep 13(1) 22729(2023) 38123655

Takahashi-Kanemitsu A, Lu M, Knight CT, Yamamoto T, Hayashi T, Mii Y, Ooki T, Kikuchi I, Kikuchi A, Barker N, Susaki EA, Taira M, Hatakeyama M.
The Helicobacter pylori CagA oncoprotein disrupts Wnt/PCP signaling and promotes hyperproliferation of pyloric gland base cells.
Sci Signal 16(794) eabp9020(2023) 37463245

Harada N, Kubo K, Onishi T, Kitakaze T, Goto T, Inui H, Yamaji R.
Androgen receptor suppresses β-adrenoceptor-mediated CREB activation and thermogenesis in brown adipose tissue of male mice.
J Biol Chem 298(12) 102619(2022) 36272644

Sasaki L, Hamada Y, Yarimizu D, Suzuki T, Nakamura H, Shimada A, Pham KTN, Shao X, Yamamura K, Inatomi T, Morinaga H, Nishimura EK, Kudo F, Manabe I, Haraguchi S, Sugiura Y, Suematsu M, Kinoshita S, Machida M, Nakajima T, Kiyonari H, Okamura H, Yamaguchi Y, Miyake T, Doi M.
Intracrine activity involving NAD-dependent circadian steroidogenic activity governs age-associated meibomian gland dysfunction.
Nat Aging 2(2) 105-114(2022) 37117756

Gleixner AM, Verdone BM, Otte CG, Anderson EN, Ramesh N, Shapiro OR, Gale JR, Mauna JC, Mann JR, Copley KE, Daley EL, Ortega JA, Cicardi ME, Kiskinis E, Kofler J, Pandey UB, Trotti D, Donnelly CJ.
NUP62 localizes to ALS/FTLD pathological assemblies and contributes to TDP-43 insolubility.
Nat Commun 13(1) 3380(2022) 35697676

Yamada S, Mizukoshi T, Tokunaga A, Sakakibara SI.
Inka2, a novel Pak4 inhibitor, regulates actin dynamics in neuronal development.
PLoS Genet 18(10) e1010438(2022) 36301793

Verdone BM, Cicardi ME, Wen X, Sriramoji S, Russell K, Markandaiah SS, Jensen BK, Krishnamurthy K, Haeusler AR, Pasinelli P, Trotti D.
A mouse model with widespread expression of the C9orf72-linked glycine-arginine dipeptide displays non-lethal ALS/FTD-like phenotypes.
Sci Rep 12(1) 5644(2022) 35379876

Murakami T, Takahata Y, Hata K, Ebina K, Hirose K, Ruengsinpinya L, Nakaminami Y, Etani Y, Kobayashi S, Maruyama T, Nakano H, Kaneko T, Toyosawa S, Asahara H, Nishimura R.
Semaphorin 4D induces articular cartilage destruction and inflammation in joints by transcriptionally reprogramming chondrocytes.
Sci Signal 15(758) eabl5304(2022) 36318619

Tanimizu N, Ichinohe N, Sasaki Y, Itoh T, Sudo R, Yamaguchi T, Katsuda T, Ninomiya T, Tokino T, Ochiya T, Miyajima A, Mitaka T.
Generation of functional liver organoids on combining hepatocytes and cholangiocytes with hepatobiliary connections ex vivo.
Nat Commun 12(1) 3390(2021) 34099675

Hayakawa M, Sakata A, Hayakawa H, Matsumoto H, Hiramoto T, Kashiwakura Y, Baatartsogt N, Fukushima N, Sakata Y, Suzuki-Inoue K, Ohmori T.
Characterization and visualization of murine coagulation factor VIII-producing cells in vivo.
Sci Rep 11(1) 14824(2021) 34290295

Harada N, Hanada K, Minami Y, Kitakaze T, Ogata Y, Tokumoto H, Sato T, Kato S, Inui H, Yamaji R.
Role of gut microbiota in sex- and diet-dependent metabolic disorders that lead to early mortality of androgen receptor-deficient male mice.
Am J Physiol Endocrinol Metab 318(4) E525-E537(2020) 32017595

Harada N, Minami Y, Hanada K, Hanaoka R, Kobayashi Y, Izawa T, Sato T, Kato S, Inui H, Yamaji R.
Relationship between gut environment, feces-to-food ratio, and androgen deficiency-induced metabolic disorders.
Gut Microbes 12(1) 1817719(2020) 32991827

Fuseya Y, Fujita H, Kim M, Ohtake F, Nishide A, Sasaki K, Saeki Y, Tanaka K, Takahashi R, Iwai K.
The HOIL-1L ligase modulates immune signalling and cell death via monoubiquitination of LUBAC.
Nat Cell Biol 22(6) 663-673(2020) 32393887

Masuya T, Suzuki M, Tsujimura J, Kanamori S, Miyasaka Y, Ohno T, Murai A, Horio F, Kobayashi M.
Ablation of Iah1, a candidate gene for diet-induced fatty liver, does not affect liver lipid accumulation in mice.
PLoS One 15(5) e0233087(2020) 32407372

Oichi T, Taniguchi Y, Soma K, Oshima Y, Yano F, Mori Y, Chijimatsu R, Kim-Kaneyama JR, Tanaka S, Saito T.
Adamts17 is involved in skeletogenesis through modulation of BMP-Smad1/5/8 pathway.
Cell Mol Life Sci 76(23) 4795-4809(2019) 31201465

Takahara S, Inoue SI, Miyagawa-Tomita S, Matsuura K, Nakashima Y, Niihori T, Matsubara Y, Saiki Y, Aoki Y.
New Noonan syndrome model mice with RIT1 mutation exhibit cardiac hypertrophy and susceptibility to β-adrenergic stimulation-induced cardiac fibrosis.
EBioMedicine 42 43-53(2019) 30898653

Miyasaka Y, Uno Y, Yoshimi K, Kunihiro Y, Yoshimura T, Tanaka T, Ishikubo H, Hiraoka Y, Takemoto N, Tanaka T, Ooguchi Y, Skehel P, Aida T, Takeda J, Mashimo T.
CLICK: one-step generation of conditional knockout mice.
BMC Genomics 19(1) 318(2018) 29720086

Maruyama T, Baba T, Maemoto Y, Hara-Miyauchi C, Hasegawa-Ogawa M, Okano HJ, Enda Y, Matsumoto K, Arimitsu N, Nakao K, Hamamoto H, Sekimizu K, Ohto-Nakanishi T, Nakanishi H, Tokuyama T, Yanagi S, Tagaya M, Tani K.
Loss of DDHD2, whose mutation causes spastic paraplegia, promotes reactive oxygen species generation and apoptosis.
Cell Death Dis 9(8) 797(2018) 30038238

Oba D, Inoue SI, Miyagawa-Tomita S, Nakashima Y, Niihori T, Yamaguchi S, Matsubara Y, Aoki Y.
Mice with an Oncogenic HRAS Mutation are Resistant to High-Fat Diet-Induced Obesity and Exhibit Impaired Hepatic Energy Homeostasis.
EBioMedicine 27 138-150(2018) 29254681

Kaitsuka T, Kiyonari H, Shiraishi A, Tomizawa K, Matsushita M.
Deletion of Long Isoform of Eukaryotic Elongation Factor 1Bδ Leads to Audiogenic Seizures and Aversive Stimulus-Induced Long-Lasting Activity Suppression in Mice.
Front Mol Neurosci 11 358(2018) 30333725

Takeshita S, Fumoto T, Ito M, Ikeda K.
Serum CTX levels and histomorphometric analysis in Src versus RANKL knockout mice.
J Bone Miner Metab 36(3) 264-273(2018) 28589412

Kiyozumi D, Taniguchi Y, Nakano I, Toga J, Yagi E, Hasuwa H, Ikawa M, Sekiguchi K.
Laminin γ1 C-terminal Glu to Gln mutation induces early postimplantation lethality.
Life Sci Alliance 1(5) e201800064(2018) 30456378

Morooka N, Futaki S, Sato-Nishiuchi R, Nishino M, Totani Y, Shimono C, Nakano I, Nakajima H, Mochizuki N, Sekiguchi K.
Polydom Is an Extracellular Matrix Protein Involved in Lymphatic Vessel Remodeling.
Circ Res 120(8) 1276-1288(2017) 28179430

Fujita Y, Masuda K, Bando M, Nakato R, Katou Y, Tanaka T, Nakayama M, Takao K, Miyakawa T, Tanaka T, Ago Y, Hashimoto H, Shirahige K, Yamashita T.
Decreased cohesin in the brain leads to defective synapse development and anxiety-related behavior.
J Exp Med 214(5) 1431-1452(2017) 28408410

Kawata M, Taniguchi Y, Mori D, Yano F, Ohba S, Chung UI, Shimogori T, Mills AA, Tanaka S, Saito T.
Different regulation of limb development by p63 transcript variants.
PLoS One 12(3) e0174122(2017) 28333962

Naganuma T, Takagi S, Kanetake T, Kitamura T, Hattori S, Miyakawa T, Sassa T, Kihara A.
Disruption of the Sjögren-Larsson Syndrome Gene Aldh3a2 in Mice Increases Keratinocyte Growth and Retards Skin Barrier Recovery.
J Biol Chem 291(22) 11676-88(2016) 27053112

Ogoh H, Tanuma N, Matsui Y, Hayakawa N, Inagaki A, Sumiyoshi M, Momoi Y, Kishimoto A, Suzuki M, Sasaki N, Ohuchi T, Nomura M, Teruya Y, Yasuda K, Watanabe T, Shima H.
The protein phosphatase 6 catalytic subunit (Ppp6c) is indispensable for proper post-implantation embryogenesis.
Mech Dev 139 1-9(2016) 26868000

Ueda T, Nakata Y, Yamasaki N, Oda H, Sentani K, Kanai A, Onishi N, Ikeda K, Sera Y, Honda ZI, Tanaka K, Sata M, Ogawa S, Yasui W, Saya H, Takita J, Honda H.
ALK(R1275Q) perturbs extracellular matrix, enhances cell invasion and leads to the development of neuroblastoma in cooperation with MYCN.
Oncogene 35(34) 4447-58(2016) 26829053

Ueda T, Nakata Y, Nagamachi A, Yamasaki N, Kanai A, Sera Y, Sasaki M, Matsui H, Honda Z, Oda H, Wolff L, Inaba T, Honda H.
Propagation of trimethylated H3K27 regulated by polycomb protein EED is required for embryogenesis, hematopoietic maintenance, and tumor suppression.
Proc Natl Acad Sci U S A 113(37) 10370-5(2016) 27578866

Liu T, Yamaguchi Y, Shirasaki Y, Shikada K, Yamagishi M, Hoshino K, Kaisho T, Takemoto K, Suzuki T, Kuranaga E, Ohara O, Miura M.
Single-cell imaging of caspase-1 dynamics reveals an all-or-none inflammasome signaling response.
Cell Rep 8(4) 974-82(2014) 25127135

Inoue S, Moriya M, Watanabe Y, Miyagawa-Tomita S, Niihori T, Oba D, Ono M, Kure S, Ogura T, Matsubara Y, Aoki Y.
New BRAF knockin mice provide a pathogenetic mechanism of developmental defects and a therapeutic approach in cardio-facio-cutaneous syndrome.
Hum Mol Genet 23(24) 6553-66(2014) 25035421

Nishibe R, Watanabe W, Ueda T, Yamasaki N, Koller R, Wolff L, Honda Z, Ohtsubo M, Honda H.
CIZ1, a p21Cip1/Waf1-interacting protein, functions as a tumor suppressor in vivo.
FEBS Lett 587(10) 1529-35(2013) 23583447

Sassa T, Ohno Y, Suzuki S, Nomura T, Nishioka C, Kashiwagi T, Hirayama T, Akiyama M, Taguchi R, Shimizu H, Itohara S, Kihara A.
Impaired epidermal permeability barrier in mice lacking elovl1, the gene responsible for very-long-chain fatty acid production.
Mol Cell Biol 33(14) 2787-96(2013) 23689133

Sugimoto M, Kondo M, Hirose M, Suzuki M, Mekada K, Abe T, Kiyonari H, Ogura A, Takagi N, Artzt K, Abe K.
Molecular identification of t(w5): Vps52 promotes pluripotential cell differentiation through cell-cell interactions.
Cell Rep 2(5) 1363-74(2012) 23142660

Kiyozumi D, Takeichi M, Nakano I, Sato Y, Fukuda T, Sekiguchi K.
Basement membrane assembly of the integrin α8β1 ligand nephronectin requires Fraser syndrome-associated proteins.
J Cell Biol 197(5) 677-89(2012) 22613833

Kobayashi M, Sabouri Z, Sabouri S, Kitawaki Y, Pommier Y, Abe T, Kiyonari H, Honjo T.
Decrease in topoisomerase I is responsible for activation-induced cytidine deaminase (AID)-dependent somatic hypermutation.
Proc Natl Acad Sci U S A 108(48) 19305-10(2011) 22080610

Kobayashi N, Miyoshi S, Mikami T, Koyama H, Kitazawa M, Takeoka M, Sano K, Amano J, Isogai Z, Niida S, Oguri K, Okayama M, McDonald JA, Kimata K, Taniguchi S, Itano N.
Hyaluronan deficiency in tumor stroma impairs macrophage trafficking and tumor neovascularization.
Cancer Res 70(18) 7073-83(2010) 20823158

Tamaki T, Uchiyama Y, Okada Y, Tono K, Masuda M, Nitta M, Hoshi A, Akatsuka A.
Clonal differentiation of skeletal muscle-derived CD34(-)/45(-) stem cells into cardiomyocytes in vivo.
Stem Cells Dev 19(4) 503-12(2010) 19634996