Strain Data Sheet
RBRC01767
Strain Information | |
|---|---|
| Image |  |
| BRC No. | RBRC01767 |
| Type | Targeted Mutation Congenic |
| Species | Mus musculus |
| Strain name | B6.129S4-Tob1<tm1Tya> Tob2<tm1Tya>/TyaRbrc |
| Former Common name | tob and tob2 KO (B6) |
| H-2 Haplotype | |
| ES Cell line | |
| Background strain | C57BL/6 |
| Appearance | |
| Strain development | Developed by Dr. Tetsuo Noda, Japanese Foundation for Cancer Research Cancer Institute at and Dr. Tadashi Yamamoto at the University of Tokyo. This strain was produced by crossing Tob1 KO mice and Tob2 KO mice. |
| Strain description | Tob is a member of antiproliferative protein family which is a negative regulator BMP/Smad signaling in osteoblasts. Tob1 null mice are viable and exhibit bone mass due to increased numbers of osteoblasts. While, Tob2 null mice appear normal. This strain is useful for elucidating of Tob gene function. |
| Colony maintenance | Backcross to C57BL/6 (Heterozygote x C57BL/6JJcl) |
| References | |
Health Report | |
|---|---|
| Examination Date / Room / Rack | |
Gene | |
|---|---|
| Gene info | Gene symbolGene nameChr.Allele symbolAllele nameCommon namesPromoter Gene symbolGene nameChr.Allele symbolAllele nameCommon namesPromoter neoneomycin resistance gene (E. coli)11neo; neomycin;mouse phosphoglycerate kinase promoter (PGK promoter) Gene symbolGene nameChr.Allele symbolAllele nameCommon namesPromoter Gene symbolGene nameChr.Allele symbolAllele nameCommon namesPromoter lacZbeta-galactosidase (E. coli)15 |
Ordering Information | |
|---|---|
| 供与核酸 | E. coli neo, mouse PGK promoter, mouse tob genomic DNA, E. coli LacZ, mouse tob2 genomic DNA |
| Research application | |
| 提供条件 | 条件を付加する。利用者は事前に寄託者の提供承諾書を得る。 共同研究 |
| Depositor | 山本 雅（国立大学法人東京大学） |
| Strain Status |  凍結胚 凍結精子 |
| Strain Availability | 凍結胚より作出したマウスを2~4ヶ月以内に提供可能 凍結精子を1ヶ月以内に提供可能 凍結胚を1ヶ月以内に提供可能 |
| Additional Info. | Necessary documents for ordering:
Genotyping protocol -PCR- |
BRC mice in Publications |
|---|
| No Data |