Strain Data Sheet

RBRC01730

Strain Information

Image
BRC No.RBRC01730
TypeTargeted MutationCartagena
SpeciesMus musculus
Strain nameC.129S2-Ptprc<tm1Tyb>/Rbrc
Former Common nameCD45 knockout mouse
H-2 Haplotype
ES Cell line
Background strainBALB/cAnNCrlCrlj
Appearance
Strain developmentVictor Tybulewiczが作製したCD45のノックアウトマウス。BALB/c バックでホモで交配可能。
Strain descriptionCD45 is a transmembrane tyrosine phosphatase implicated in the control of T cell receptor signaling. CD45 homozygous mutant mice in the BALB/c background were gorssly normal and fertile.
Colony maintenanceBackcross to BALB/c (Heterozygote x BALB/cAnN)
ReferencesEur. J. Immunol., 29, 2923-2933 (1999). 10508267

Health Report

Examination Date / Room / Rack2024/02/26Room:4-BRack:D

Gene

Gene info
Gene symbolGene nameChr.Allele symbolAllele nameCommon namesPromoter
Ptprcprotein tyrosine phosphatase, receptor type, C1Ptprc<tm1Tyb>targeted mutation 1, Victor L J TybulewiczB220, CD45, Cd45, CD45R, Ly-5, LY-5, Lyt-4, T200

Gene symbolGene nameChr.Allele symbolAllele nameCommon namesPromoter
neoneomycin resistance gene (E. coli)1neo; neomycin;mouse phosphoglycerate kinase promoter (PGK promoter)

Gene symbolGene nameChr.Allele symbolAllele nameCommon namesPromoter
poly AHSV TK polyA1poly A

Ordering Information

供与核酸mouse Phosphoglycerate kinase-1 (PGK) promoter, E.coli neo, HSV TK PolyA, mouse CD45 genomic DNA
Research applicationImmunology and Inflammation Research
提供条件条件を付加する。
研究成果の公表にあたって寄託者の指定する文献を引用する。Eur. immunol., 29, 2923-2933 (1999).
学術研究目的に限る。事前に開発者（Dr. Victor Tybulewicz) に連絡し、必要な手続きを行い、使用許可を得る。
Depositor小安　重夫（慶應義塾大学）
Strain Status生体のアイコン生体
凍結胚のアイコン凍結胚
凍結精子のアイコン凍結精子
Strain Availability凍結精子を1ヶ月以内に提供可能
生体マウスを3~6ヶ月以内に提供可能
Additional Info.Necessary documents for ordering:
  1. Order form (Japanese / English)
  2. Category I MTA: MTA for distribution with RIKEN BRC (Japanese / English)
  3. Acceptance of responsibility for living modified organism (Japanese / English)
Lab HP
Genotyping protocol -PCR-

BRC mice in Publications

No Data