Strain Data Sheet

RBRC01721

Strain Information

Image
BRC No.RBRC01721
TypeTransgeneCartagena
SpeciesMus musculus
Strain nameB6.Cg-Tg(Emu-BCL2L1)87Nnz/Rbrc
Former Common nameBcl-xL Tg
H-2 Haplotype
ES Cell line
Background strainC57BL/6NCrlCrlj
Appearanceblack [a/a B/B C/C]
Strain developmentNunez のところで作製された Bcl-xL をB細胞特異的に発現するマウス(line #87) 。数代戻し交配されたいたものをさらに19代 C57BL/6NTac へ戻し交配。
Strain descriptionC57BL/6-Tg(SV40-BCL2L1)87Nnz. Bcl-xL, a member of the bcl-2 amily, is expressed in pre-B cells but downregulated at the immature and mature stages of B cell development. This transgenic mouse strain expresses the human Bcl-xL gene within B cell lineage under the control of the SV40 promoter and B IgH enhancer. The transgenic mice show marked accumulation of peripheral B cells in lymphoid organs and enhanced B cell survival in vitro.
Colony maintenanceBackcross to C57BL/6 (Hemizygote x C57BL/6NCrj).
ReferencesJ. Exp. Med., 183, 381-391 (1996). 8627151

Health Report

Examination Date / Room / Rack

Gene

Gene info
Gene symbolGene nameChr.Allele symbolAllele nameCommon namesPromoter
BCL2L1Bcl2-like 1UNBCL2L1bcl-x, Bcl-XL, Bcl-Xs, BclXmouse Immunogloblin Eu enhancer, SV 40 early promoter, SV40 poly A additional signal

Gene symbolGene nameChr.Allele symbolAllele nameCommon namesPromoter
poly ASV40 polyA signal sequenceUNpoly A

Ordering Information

供与核酸mouse IgH enhancer, human Bcl-xL cDNA, SV40 early promoter and poly A (SV40-EH cassette)
Research application
提供条件条件を付加する。
研究成果の公表にあたって寄託者の指定する文献を引用する。J. Exp. Med., 183, 381-391 (1991).
学術研究目的に限る。事前に開発者（Dr. Timothy W. Behens) に連絡し、必要な手続きを行い、使用許可を得る。
Depositor小安　重夫（慶應義塾大学）
Strain Status凍結胚のアイコン凍結胚
凍結精子のアイコン凍結精子
Strain Availability凍結胚より作出したマウスを2~4ヶ月以内に提供可能
凍結精子を1ヶ月以内に提供可能
凍結胚を1ヶ月以内に提供可能
Additional Info.Necessary documents for ordering:
  1. Order form (Japanese / English)
  2. Category I MTA: MTA for distribution with RIKEN BRC (Japanese / English)
  3. Acceptance of responsibility for living modified organism (Japanese / English)
Lab HP
Genotyping protocol -PCR-

BRC mice in Publications

No Data