Strain Data Sheet

RBRC01712

Strain Information

Image
BRC No.RBRC01712
TypeTargeted MutationCartagena
SpeciesMus musculus
Strain nameD2.129S-Ahr<tm1Yfk>
Former Common nameAhR(DBA/2)+/- mouse
H-2 Haplotype
ES Cell lineCCE/EK.CCE [129S/SvEv-Gpi1<c>]
Background strain
Appearance
Strain developmentDeveloped by Drs. Yoshiaki Fujii-Kuriyama and Junsei Mimura at Tohoku University in 1997. The mutant mice are backcrossed to DBA/2.
Strain descriptionダイオキシン受容体ノックアウトマウス。
Colony maintenanceBackcross to DBA/2 (Heterozygote x DBA/2JJcl)AhR(-/-)雌マウスは生殖能が低い
ReferencesGenes Cells, 2, 645-654 (1997). 9427285

Health Report

Examination Date / Room / Rack

Gene

Gene info
Gene symbolGene nameChr.Allele symbolAllele nameCommon namesPromoter
Ahraryl-hydrocarbon receptor12Ahr<tm1Yfk>targeted mutation 1, Yoshiaki Fujii-KuriyamaAh, Ahh, Ahre, dioxin receptor, In

Gene symbolGene nameChr.Allele symbolAllele nameCommon namesPromoter
lacZbeta-galactosidase (E. coli)12

Gene symbolGene nameChr.Allele symbolAllele nameCommon namesPromoter
neoneomycin resistance gene (E. coli)12neo; neomycin;herpes simplex virus thymidine kinase promoter (HSV tk promoter)

Gene symbolGene nameChr.Allele symbolAllele nameCommon namesPromoter
nlsSV40 large T antigen nuclear localization signal (NLS)12nls

Ordering Information

供与核酸E. coli lacZ, Simian virus 40 Large T antigen nuclear localization signal (NLS), E. coli neo, mouse Ahr genomic DNA, herpes simplex virus thymidine kinase promoter (HSV tk promoter), SV40 T antigen intron and polyadenylation signal
Research applicationMetabolism Research
提供条件条件を付加する。利用者は事前に寄託者の提供承諾書を得る。
研究成果の公表にあたって謝辞の表明を必要とする。
寄託後2年間は共著を必要とする共同研究とする。当該リソースを使用した研究成果に基づき特許等の申請を行う場合は寄託者と別途協議を行う。
Depositor藤井 義明(国立大学法人筑波大学)
Strain Status凍結胚のアイコン凍結胚
凍結精子のアイコン凍結精子
Strain Availability凍結胚より作出したマウスを2~4ヶ月以内に提供可能
凍結精子を1ヶ月以内に提供可能
凍結胚を1ヶ月以内に提供可能
Additional Info.Necessary documents for ordering:
  1. Approval form (Japanese / English)
  2. Order form (Japanese / English)
  3. Category I MTA: MTA for distribution with RIKEN BRC (Japanese / English)
  4. Acceptance of responsibility for living modified organism (Japanese / English)

Genotyping protocol -PCR-

BRC mice in Publications

Ishikawa T, Okinaga H, Takahashi S, Numakura M, Mashimo Y, Yoshimura N, Maeda T, Inoue D, Okazaki R, Kinoshita M, Jameson JL, Teramoto T.
Serum from methimazole-treated patients induces activation of aryl hydrocarbon receptor, a transcription factor that binds to dioxin-response elements.
Thyroid 22(8) 769-77(2012) 22784254