Strain Information | |
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Image | |
BRC No. | RBRC01712 |
Type | Targeted Mutation |
Species | Mus musculus |
Strain name | D2.129S-Ahr<tm1Yfk> |
Former Common name | AhR(DBA/2)+/- mouse |
H-2 Haplotype | |
ES Cell line | CCE/EK.CCE [129S/SvEv-Gpi1<c>] |
Background strain | |
Appearance | |
Strain development | Developed by Drs. Yoshiaki Fujii-Kuriyama and Junsei Mimura at Tohoku University in 1997. The mutant mice are backcrossed to DBA/2. |
Strain description | ダイオキシン受容体ノックアウトマウス。 |
Colony maintenance | Backcross to DBA/2 (Heterozygote x DBA/2JJcl)AhR(-/-)雌マウスは生殖能が低い |
References | Genes Cells, 2, 645-654 (1997). 9427285 |
Health Report | |
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Examination Date / Room / Rack |
Gene | |
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Gene info | Gene symbolGene nameChr.Allele symbolAllele nameCommon namesPromoter Ahraryl-hydrocarbon receptor12Ahr<tm1Yfk>targeted mutation 1, Yoshiaki Fujii-KuriyamaAh, Ahh, Ahre, dioxin receptor, In Gene symbolGene nameChr.Allele symbolAllele nameCommon namesPromoter lacZbeta-galactosidase (E. coli)12 Gene symbolGene nameChr.Allele symbolAllele nameCommon namesPromoter neoneomycin resistance gene (E. coli)12neo; neomycin;herpes simplex virus thymidine kinase promoter (HSV tk promoter) Gene symbolGene nameChr.Allele symbolAllele nameCommon namesPromoter nlsSV40 large T antigen nuclear localization signal (NLS)12nls |
Ordering Information | |
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供与核酸 | E. coli lacZ, Simian virus 40 Large T antigen nuclear localization signal (NLS), E. coli neo, mouse Ahr genomic DNA, herpes simplex virus thymidine kinase promoter (HSV tk promoter), SV40 T antigen intron and polyadenylation signal |
Research application | Metabolism Research |
提供条件 | 条件を付加する。利用者は事前に寄託者の提供承諾書を得る。 研究成果の公表にあたって謝辞の表明を必要とする。 寄託後2年間は共著を必要とする共同研究とする。当該リソースを使用した研究成果に基づき特許等の申請を行う場合は寄託者と別途協議を行う。 |
Depositor | 藤井 義明(国立大学法人筑波大学) |
Strain Status | 凍結胚 凍結精子 |
Strain Availability | 凍結胚より作出したマウスを2~4ヶ月以内に提供可能 凍結精子を1ヶ月以内に提供可能 凍結胚を1ヶ月以内に提供可能 |
Additional Info. | Necessary documents for ordering:
Genotyping protocol -PCR- |
BRC mice in Publications |
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Ishikawa T, Okinaga H, Takahashi S, Numakura M, Mashimo Y, Yoshimura N, Maeda T, Inoue D, Okazaki R, Kinoshita M, Jameson JL, Teramoto T. Serum from methimazole-treated patients induces activation of aryl hydrocarbon receptor, a transcription factor that binds to dioxin-response elements. Thyroid 22(8) 769-77(2012) 22784254 |