Strain Data Sheet

RBRC01710

Strain Information

Image
BRC No.RBRC01710
TypeTargeted MutationCartagena
SpeciesMus musculus
Strain nameB6.129S-Ahr<tm1Yfk>
Former Common nameAhR(C57BL6j)-/- mouse
H-2 Haplotype
ES Cell lineCCE/EK.CCE [129S/SvEv-Gpi1<c>]
Background strain
Appearanceblack [a/a B/B C/C]
Strain developmentC57BL6/J (N7)
Strain descriptionB6.129S-Ahr<tm1Yfk>. The aryl hydrocarbon receptor (AhR) (dioxin receptor) is a transcription factor that mediate to catalyze xenobiotic Phase I metabolism. Homozygous mutant mice shows a slightly slower growth rate compared than wild-types for the first few weeks of life.
Colony maintenanceAhR(-/-)雌マウスは生殖能が低い
ReferencesGenes Cells, 2, 645-654 (1997). 9427285

Health Report

Examination Date / Room / Rack

Gene

Gene info
Gene symbolGene nameChr.Allele symbolAllele nameCommon namesPromoter
Ahraryl-hydrocarbon receptor12Ahr<tm1Yfk>targeted mutation 1, Yoshiaki Fujii-KuriyamaAh, Ahh, Ahre, dioxin receptor, In

Gene symbolGene nameChr.Allele symbolAllele nameCommon namesPromoter
lacZbeta-galactosidase (E. coli)12

Gene symbolGene nameChr.Allele symbolAllele nameCommon namesPromoter
neoneomycin resistance gene (E. coli)12neo; neomycin;herpes simplex virus thymidine kinase promoter (HSV tk promoter)

Gene symbolGene nameChr.Allele symbolAllele nameCommon namesPromoter
nlsSV40 large T antigen nuclear localization signal (NLS)12nls

Ordering Information

供与核酸Simian virus 40 Large T antigen nuclear localization signal (NLS), E. coli lacZ, herpes simplex virus thymidine kinase promoter (HSV tk promoter), E. coli neo, SV40 T antigen intron and polyadenylation signal, mouse Ahr genomic DNA
Research application
提供条件条件を付加する。利用者は事前に寄託者の提供承諾書を得る。
研究成果の公表にあたって謝辞の表明を必要とする。
寄託後2年間は共著を必要とする共同研究とする。当該リソースを使用した研究成果に基づき特許等の申請を行う場合は寄託者と別途協議を行う。
Depositor藤井　義明（国立大学法人筑波大学）
Strain Status凍結胚のアイコン凍結胚
凍結精子のアイコン凍結精子
Strain Availability凍結精子より作出したマウスを2~4ヶ月以内に提供可能
凍結精子を1ヶ月以内に提供可能
Additional Info.Necessary documents for ordering:
  1. Approval form (Japanese / English)
  2. Order form (Japanese / English)
  3. Category I MTA: MTA for distribution with RIKEN BRC (Japanese / English)
  4. Acceptance of responsibility for living modified organism (Japanese / English)

Genotyping protocol -PCR-
Genetic Background

BRC mice in Publications

Kimura E, Kohda M, Maekawa F, Fujii-Kuriyama Y, Tohyama C.
Neurons expressing the aryl hydrocarbon receptor in the locus coeruleus and island of Calleja major are novel targets of dioxin in the mouse brain.
Histochem Cell Biol 156(2) 147-163(2021) 33963922

Okudaira N, Okamura T, Tamura M, Iijma K, Goto M, Matsunaga A, Ochiai M, Nakagama H, Kano S, Fujii-Kuriyama Y, Ishizaka Y.
Long interspersed element-1 is differentially regulated by food-borne carcinogens via the aryl hydrocarbon receptor.
Oncogene 32(41) 4903-12(2013) 23208499