Strain Data Sheet



BRC No.RBRC01707
SpeciesMus musculus
Strain nameB6.Cg-Tg(Mt1-RET)192Ina
Former Common name192 RET
H-2 Haplotype
ES Cell line
Background strain
Strain developmentDeveloped by Masashi Kato, Nagoya University Graduate School of Medicine. The transgene was injected into the pronuclei of (BALB/c x C57BL/6) x BALB/c fertilized eggs. C57BL/6 and BALB/c mixed background.
Strain descriptionThis strain expresses the human RET gene under the control of the mouse Mt1 promoter/enhancer. This Mt1-RET 192 line develops benign tumors 100% within several months after birth. However they never transform to malignant tumors. Crossing with C57BL/6 multiple times makes this strain more difficult to maintain because of the earlier onset of tumors.
Colony maintenanceCarrier x Noncarrier
ReferencesEMBO J., 10, 3167-3175 (1991). 1915289

Health Report

Examination Date / Room / Rack


Gene info
Gene symbolGene nameChr.Allele symbolAllele nameCommon namesPromoter
Tg(Mt1-RET)192Inatransgene insertion 192, Izumi NakashimaUNTg(Mt1-RET)192InaTg(Mt1-RET)192Num, Tg(Mt1-RFP/RET)192Num

Gene symbolGene nameChr.Allele symbolAllele nameCommon namesPromoter
RETrecombinant RET proto-oncogene (human)UNRETRET51, RET9mouse metallothionein 1 promoter/enhancer

Gene symbolGene nameChr.Allele symbolAllele nameCommon namesPromoter
SV40 splicing signal-polyadenylation siteUN


Donor DNAhuman RFP/RET cDNA, mouse MT-I promoter-enhancer, SV40 splicing signal-polyadenylation site, vector sequence
Research applicationCancer Research
Dermatology Research
Mouse Models for Human Disease
Specific Term and ConditionsThe RECIPIENT of BIOLOGICAL RESOURCE shall obtain a prior written consent on use of it from the DEPOSITOR. The RECIPIENT of BIOLOGICAL RESOURCE must obtain a prior written consent on use of it from the DEPOSITOR/DEVELOPER. The RECIPIENT must contact the DEPOSITOR in the case of application for any patents or commercial use with the results from the use of the BIOLOGICAL RESOURCE. The RECIPIENT agrees to use this BIOLOGICAL RESOURCE as a collaboration with the DEPOSITOR.
DepositorMasashi Kato (Chubu University)
Strain Statusan icon for Frozen embryosFrozen embryos
Strain AvailabilityRecovered litters from cryopreserved embryos (2 to 4 months)
Cryopreserved embryos (within 1 month)
Additional Info.Necessary documents for ordering:
  1. Approval form (Japanese / English)
  2. Order form (Japanese / English)
  3. Category I MTA: MTA for distribution with RIKEN BRC (Japanese / English)
  4. Acceptance of responsibility for living modified organism (Japanese / English)

Genotyping protocol -PCR-

BRC mice in Publications

No Data