Strain Data Sheet

RBRC01686

Strain Information

Image
BRC No.RBRC01686
TypeTargeted MutationCartagena
SpeciesMus musculus
Strain nameB6.Cg-Pcdha<tm1Tyag>/TyagRbrc
Former Common nameG1, CNR G1
H-2 Haplotype
ES Cell lineTT2 [(C57BL/6NCrlj x CBA/JNCrlj)F1]
Background strain
Appearance
Strain development
Strain description
Colony maintenance
References
Distinct and Cooperative Functions for the Protocadherin-alpha, -beta and -gamma Clusters in Neuronal Survival and Axon Targeting.
Hasegawa S, Kumagai M, Hagihara M, Nishimaru H, Hirano K, Kaneko R, Okayama A, Hirayama T, Sanbo M, Hirabayashi M, Watanabe M, Hirabayashi T, Yagi T
Front. Mol. Neurosci., 9:155 (2016). 28066179

Health Report

Examination Date / Room / Rack

Gene

Gene SymbolGene NameChr.Allele SymbolAllele NameCommon NamesPromoterDiseases Related to This Gene
Pcdha
MGI:3719085		protocadherin alpha cluster18Pcdha<tm1Tyag>
MGI:3797608		targeted mutation 1, Takeshi Yagi
loxP phage P1 loxP18loxP

Phenotype

Annotation by Mammalian phenotyhpe ontology
  • abnormal limb bone morphology(MP:0002115)

  • abnormal spinal cord interneuron morphology(MP:0004100)

  • decreased spinal cord size(MP:0000956)

  • hunched posture(MP:0001505)

  • increased neuron apoptosis(MP:0003203)
    • more 3 phenotypes
  • loss of GABAergic neurons(MP:0003246)

  • neonatal lethality(MP:0002058)

  • tremors(MP:0000745)
    • Detailed phenotype data

    Ordering Information

    Donor DNAPhage P1 loxP, mouse Pcdha genomic DNA
    Research applicationCre/loxP system
    Specific Term and ConditionsThe RECIPIENT of BIOLOGICAL RESOURCE shall obtain a prior written consent on use of it from the DEPOSITOR. If the RECIPIENT's research results in an invention based on the BIOLOGICAL RESOURCE, the RECIPIENT must contact DEPOSITOR to negotiate. In publishing the research results to be obtained by use of the BIOLOGICAL RESOURCE, the RECIPIENT must obtain a prior written consent from the DEPOSITOR.
    DepositorTakeshi Yagi (Osaka University)
    Strain Statusan icon for Frozen embryosFrozen embryos
    an icon for Frozen spermFrozen sperm
    Strain AvailabilityRecovered litters from cryopreserved embryos (2 to 4 months)
    Cryopreserved sperm (within 1 month)
    Cryopreserved embryos (within 1 month)
    Additional Info.Necessary documents for ordering:
    1. Approval form (Japanese / English)
    2. Order form (Japanese / English)
    3. Category I MTA: MTA for distribution with RIKEN BRC (Japanese / English)
    4. Acceptance of responsibility for living modified organism (Japanese / English)
    Lab HP (Japanese)

    BRC mice in Publications

    No Data