Strain Information | |
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Image | |
BRC No. | RBRC01670 |
Type | Inbred |
Species | Mus musculus |
Strain name | DDD/Sgn |
Former Common name | |
H-2 Haplotype | |
ES Cell line | |
Background strain | DDD |
Appearance | |
Strain development | According to Tanaka Matsuzawa (1990) "Inbreeding of dd mice maintained at Denken was commenced in 1957 and the resulting inbred strain was named DDD after dd at Denken. The ancestors of dd mice had come from Germany.F164 |
Strain description | Mammary tumours 8% at 14 months in virgin and 14% at 14 months in force-bred females. Mammary tumour virus carried by the strain is probably of plaque-inducing group found in DD, RIII and BR6 but not in C3H (Matsuzawa et al., 1974., 1974). Develop a high incidence of heritable hydronephrosis, with a higher incidence observed in males and females. This appears to be caused by an abnormally high internal pressure in the renal pelvis leading to incomplete protection against the vesico-urethral reflex (Mannen et al 1991). Host of a very stable, transplantable pregnancy-dependent mammary tumour TPDMT-4 (Matsuzawa and Yamamoto, 1975). Resistant to the development of uterine tumours following treatment with DMBA at 4-weeks of age (cf 3/6) (Tsubura et al, 1993). High incidence of lethality among F1 Dh/+ male mice resulting from a cross between DDD females and DH-Dh/+ males, however, this is not observed in the reciprocal cross (Suto et al, 1996). |
Colony maintenance | 繁殖効率:A |
References | Exp. Anim., 45, 99-101 (1996). 8689589 |
Health Report | |
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Examination Date / Room / Rack |
Gene | |
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Gene info |
Ordering Information | |
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供与核酸 | |
Research application | |
提供条件 | 条件を付加しない。 |
Depositor | 後藤 英夫(独立行政法人農業生物資源研究所) |
Strain Status | 凍結胚 |
Strain Availability | 凍結胚より作出したマウスを2~4ヶ月以内に提供可能 凍結胚を1ヶ月以内に提供可能 |
Additional Info. | Necessary documents for ordering: |
BRC mice in Publications |
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Kasahara T, Abe K, Mekada K, Yoshiki A, Kato T. Genetic variation of melatonin productivity in laboratory mice under domestication. Proc Natl Acad Sci U S A 107(14) 6412-7(2010) 20308563 |