Strain Information | |
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Image | |
BRC No. | RBRC01532 |
Type | Targeted Mutation |
Species | Mus musculus |
Strain name | B6.Cg-Il6st<tm1Thir>/ThirRbrc |
Former Common name | F759 |
H-2 Haplotype | |
ES Cell line | |
Background strain | |
Appearance | |
Strain development | |
Strain description | |
Colony maintenance | |
References | Dissection of signaling cascades through gp130 in vivo: reciprocal roles for STAT3- and SHP2-mediated signals in immune responses. Ohtani T, Ishihara K, Atsumi T, Nishida K, Kaneko Y, Miyata T, Itoh S, Narimatsu M, Maeda H, Fukada T, Itoh M, Okano H, Hibi M, Hirano T Immunity, 12, 95-105 (2000). 10661409A point mutation of Tyr-759 in interleukin 6 family cytokine receptor subunit gp130 causes autoimmune arthritis. Atsumi T, Ishihara K, Kamimura D, Ikushima H, Ohtani T, Hirota S, Kobayashi H, Park S J, Saeki Y, Kitamura Y, Hirano T J. Exp. Med., 196, 979-990 (2002). 12370259 |
Health Report | |
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Examination Date / Room / Rack |
Gene | |||||||
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Gene Symbol | Gene Name | Chr. | Allele Symbol | Allele Name | Common Names | Promoter | Diseases Related to This Gene |
Il6st | interleukin 6 signal transducer | 13 | Il6st | targeted mutation 1, Toshio Hirano | |||
neo | neomycin resistance gene (E. coli) | 13 |
Phenotype | |
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Annotation by Mammalian phenotyhpe ontology | more 38 phenotypes |
Detailed phenotype data |
Ordering Information | |
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Donor DNA | human gp130遺伝子 cDNA, E. coli neo 遺伝子 |
Research application | Immunology and Inflammation Research covid19_onset |
Specific Term and Conditions | In publishing the research results obtained by use of the BIOLOGICAL RESOURCE, a citation of the following literature(s) designated by the DEPOSITOR is requested. J. Exp Med., 196, 979-990 (2002). Immunity, 12, 95-105 (2000). |
Depositor | Toshio Hirano (Osaka University) |
Strain Status | Frozen sperm |
Strain Availability | Recovery and QC required prior to distribution |
Additional Info. | Necessary documents for ordering:
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BRC mice in Publications |
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