Strain Data Sheet

RBRC01531

Strain Information

Image
BRC No.RBRC01531
TypeTargeted MutationCartagena
SpeciesMus musculus
Strain nameB6.Cg-Il6st<tm2Thir>/ThirRbrc
Former Common nameFxxQ, C57BL/6gp130<FxxQ/FxxQ>
H-2 Haplotype
ES Cell line
Background strain
Appearance
Strain development
Strain description
Colony maintenance
References
Dissection of signaling cascades through gp130 in vivo: reciprocal roles for STAT3- and SHP2-mediated signals in immune responses.
Ohtani T, Ishihara K, Atsumi T, Nishida K, Kaneko Y, Miyata T, Itoh S, Narimatsu M, Maeda H, Fukada T, Itoh M, Okano H, Hibi M, Hirano T
Immunity, 12, 95-105 (2000). 10661409

A point mutation of Tyr-759 in interleukin 6 family cytokine receptor subunit gp130 causes autoimmune arthritis.
Atsumi T, Ishihara K, Kamimura D, Ikushima H, Ohtani T, Hirota S, Kobayashi H, Park S J, Saeki Y, Kitamura Y, Hirano T
J. Exp. Med., 196, 979-990 (2002). 12370259

Health Report

Examination Date / Room / Rack

Gene

Gene SymbolGene NameChr.Allele SymbolAllele NameCommon NamesPromoterDiseases Related to This Gene
Il6st
MGI:96560		interleukin 6 signal transducer13Il6st<tm2Thir>
MGI:2386993		targeted mutation 2, Toshio Hirano
  • hyper-IgE recurrent infection syndrome 4, autosomal recessive(MedGEN)
    • neo neomycin resistance gene (E. coli)13

    Phenotype

    Annotation by Mammalian phenotyhpe ontology
  • abnormal bone marrow cell morphology/development(MP:0002398)

  • abnormal dendritic cell antigen presentation(MP:0002455)

  • abnormal osteoblast physiology(MP:0005006)

  • decreased B-1a cell number(MP:0008168)

  • decreased IgG1 level(MP:0008495)
    • more 5 phenotypes
  • decreased IgG2a level(MP:0008496)

  • decreased IgG2b level(MP:0008497)

  • decreased interferon-gamma secretion(MP:0008567)

  • increased IgM level(MP:0002494)

  • neonatal lethality, complete penetrance(MP:0011087)
    • Detailed phenotype data

    Ordering Information

    Donor DNAhuman gp130遺伝子 cDNA, E. coli neo 遺伝子
    Research applicationImmunology and Inflammation Research
    covid19_onset
    Specific Term and ConditionsIn publishing the research results obtained by use of the BIOLOGICAL RESOURCE, a citation of the following literature(s) designated by the DEPOSITOR is requested. J. Exp Med., 196, 979-990 (2002). Immunity, 12, 95-105 (2000).
    DepositorToshio Hirano (Osaka University)
    Strain Statusan icon for Frozen spermFrozen sperm
    Strain AvailabilityRecovery and QC required prior to distribution
    Additional Info.Necessary documents for ordering:
    1. Order form (Japanese / English)
    2. Category I MTA: MTA for distribution with RIKEN BRC (Japanese / English)
    3. Acceptance of responsibility for living modified organism (Japanese / English)
    Lab HP

    BRC mice in Publications

    No Data