Strain Data Sheet

RBRC01530

Strain Information

Image
BRC No.RBRC01530
TypeTargeted MutationCartagena
SpeciesMus musculus
Strain nameB6.Cg-Il6st<tm1Thir>/ThirRbrc
Former Common nameWH, C57BL/6 gp130<WH/WH>
H-2 Haplotype
ES Cell line
Background strain
Appearance
Strain development
Strain description
Colony maintenance
References
Dissection of signaling cascades through gp130 in vivo: reciprocal roles for STAT3- and SHP2-mediated signals in immune responses.
Ohtani T, Ishihara K, Atsumi T, Nishida K, Kaneko Y, Miyata T, Itoh S, Narimatsu M, Maeda H, Fukada T, Itoh M, Okano H, Hibi M, Hirano T
Immunity, 12, 95-105 (2000). 10661409

A point mutation of Tyr-759 in interleukin 6 family cytokine receptor subunit gp130 causes autoimmune arthritis.
Atsumi T, Ishihara K, Kamimura D, Ikushima H, Ohtani T, Hirota S, Kobayashi H, Park S J, Saeki Y, Kitamura Y, Hirano T
J. Exp. Med., 196, 979-990 (2002). 12370259

Health Report

Examination Date / Room / Rack

Gene

Gene SymbolGene NameChr.Allele SymbolAllele NameCommon NamesPromoterDiseases Related to This Gene
Il6stinterleukin 6 signal transducer13Il6sttargeted mutation 1, Toshio Hirano
  • hyper-IgE recurrent infection syndrome 4, autosomal recessive(MedGEN)
  • neoneomycin resistance gene (E. coli)13
  • hyper-IgE recurrent infection syndrome 4, autosomal recessive(MedGEN)
  • Phenotype

    Annotation by Mammalian phenotyhpe ontology
  • abnormal B cell physiology(MP:0002459)

  • abnormal T cell activation(MP:0001828)

  • abnormal T cell clonal deletion(MP:0005002)

  • abnormal action potential(MP:0005402)

  • abnormal bone structure(MP:0003795)
  • more 33 phenotypes
  • abnormal channel response intensity(MP:0003486)

  • abnormal dendritic cell antigen presentation(MP:0002455)

  • abnormal myocardial fiber physiology(MP:0004215)

  • abnormal osteoblast physiology(MP:0005006)

  • abnormal peritoneum morphology(MP:0009216)

  • abnormal thymocyte activation(MP:0003850)

  • decreased double-positive T cell number(MP:0005092)

  • decreased interleukin-4 secretion(MP:0008700)

  • increased B cell number(MP:0005014)

  • increased CD4-positive, alpha-beta T cell number(MP:0008074)

  • increased CD8-positive, alpha-beta T cell number(MP:0008078)

  • increased IgA level(MP:0002495)

  • increased IgG1 level(MP:0008499)

  • increased IgG2a level(MP:0008500)

  • increased IgG2b level(MP:0008501)

  • increased activated T cell number(MP:0001829)

  • increased anti-double stranded DNA antibody level(MP:0004762)

  • increased anti-nuclear antigen antibody level(MP:0004794)

  • increased anti-single stranded DNA antibody level(MP:0004771)

  • increased autoantibody level(MP:0003725)

  • increased bone mineral content(MP:0010123)

  • increased bone mineral density(MP:0000062)

  • increased bone mineralization(MP:0020080)

  • increased bone ossification(MP:0020039)

  • increased double-negative T cell number(MP:0005090)

  • increased interferon-gamma secretion(MP:0008566)

  • increased neutrophil cell number(MP:0000219)

  • increased single-positive T cell number(MP:0008082)

  • increased trabecular bone thickness(MP:0009347)

  • lymph node hyperplasia(MP:0008102)

  • osteoporosis(MP:0000066)

  • rheumatoid arthritis(MP:0003561)

  • spleen hyperplasia(MP:0000693)
  • Detailed phenotype data

    Ordering Information

    Donor DNAhuman gp130遺伝子 cDNA, E. coli neo 遺伝子
    Research applicationImmunology and Inflammation Research
    covid19_onset
    Specific Term and ConditionsIn publishing the research results obtained by use of the BIOLOGICAL RESOURCE, a citation of the following literature(s) designated by the DEPOSITOR is requested. J. Exp Med., 196, 979-990 (2002). Immunity, 12, 95-105 (2000).
    DepositorToshio Hirano (Osaka University)
    Strain Statusan icon for Frozen spermFrozen sperm
    Strain AvailabilityRecovery and QC required prior to distribution
    Additional Info.Necessary documents for ordering:
    1. Order form (Japanese / English)
    2. Category I MTA: MTA for distribution with RIKEN BRC (Japanese / English)
    3. Acceptance of responsibility for living modified organism (Japanese / English)
    Lab HP

    BRC mice in Publications

    No Data