Strain Data Sheet

RBRC01491

Strain Information

Image
BRC No.RBRC01491
TypeTargeted MutationCartagena
SpeciesMus musculus
Strain nameB6.Cg-Lrrn4<tm1Ami>/Rbrc
Former Common nameNLRR4-KO(B6); B6.Cg-B430119L13Rik<tm>, B6;B6CB-Lrrn4<tm1>/Rbrc
H-2 Haplotype
ES Cell lineTT2 [(C57BL/6NCrlj x CBA/JNCrlj)F1]
Background strain
Appearanceblack [a/a B/B C/C]
Strain development開発年：2001年開発者：坂東高功先生、宮島篤先生機関名：東京大学、分子細胞生物学研究所
Strain descriptionB6.Cg-B430119L13Rik<tm>. NLRR4 is a member of the neuronal leucine-rich repeat protein family. NLRR proteins are type I transmembrane proteins with leucine-rich repeats and a fibronectine type III repeat, and expressed in neuronal tissues. NLRR4 deficient mice have a severe damage to their long-term memory in hippocampus-dependent tasks, while their hippocampal long-term potentiation was intact. NLRR4 plays a role in hippocamus-dependent long-lasting memory.
Colony maintenance繁殖効率：A行動の異常がある
ReferencesMol. Cell. Biol., 25, 4166-4175 (2005). 15870286

Health Report

Examination Date / Room / Rack

Gene

Gene info
Gene symbolGene nameChr.Allele symbolAllele nameCommon namesPromoter
Lrrn4leucine rich repeat neuronal 42Lrrn4<tm1Ami>targeted mutation 1, Atsushi MiyajimaB430119L13Rik

Gene symbolGene nameChr.Allele symbolAllele nameCommon namesPromoter
lacZbeta-galactosidase (E. coli)2

Gene symbolGene nameChr.Allele symbolAllele nameCommon namesPromoter
neoneomycin resistance gene (E. coli)2neo; neomycin;mouse phosphoglycerate kinase promoter (PGK promoter)

Ordering Information

供与核酸mouse phosphoglycerate kinase promoter (PGK promoter), E. coli neo, E. coli lacZ, poly A, mouse Lrrn4 genomic DNA
Research application
提供条件条件を付加する。利用者は事前に寄託者の提供承諾書を得る。
研究成果の公表にあたって寄託者の指定する文献を引用する。Mol. Cell Biol., 10, 4160-4175 (2005).
寄託者の承諾を得る。
Depositor宮島　篤（国立大学法人東京大学）
Strain Status凍結胚のアイコン凍結胚
凍結精子のアイコン凍結精子
Strain Availability凍結胚より作出したマウスを2~4ヶ月以内に提供可能
凍結精子を1ヶ月以内に提供可能
凍結胚を1ヶ月以内に提供可能
Additional Info.Necessary documents for ordering:
  1. Approval form (Japanese / English)
  2. Order form (Japanese / English)
  3. Category I MTA: MTA for distribution with RIKEN BRC (Japanese / English)
  4. Acceptance of responsibility for living modified organism (Japanese / English)
Lab HP (Japanese)
Genotyping protocol -PCR-

BRC mice in Publications

No Data