Strain Data Sheet

RBRC01475

Strain Information

Image
BRC No.RBRC01475
TypeTargeted MutationCartagena
SpeciesMus musculus
Strain nameB6;129-Fas<tm1Osa>/OsaRbrc
Former Common nameAgouti Fas-KO
H-2 Haplotype
ES Cell lineE14.1 [129P2/OlaHsd]
Background strain
Appearance
Strain developmentDeveloped by Drs. Masashi Adachi and Shigekazu Nagata at Osaka University Medical School in 1995.
Strain description
Colony maintenanceSibling Mating (Heterozygote x Wild-type, Heterozygote)
References
Targeted mutation in the Fas gene causes hyperplasia in peripheral lymphoid organs and liver.
Adachi M, Suematsu S, Kondo T, Ogasawara J, Tanaka T, Yoshida N, Nagata S
Nat. Genet., 11(3), 294-300 (1995). 7581453

Health Report

Examination Date / Room / Rack

Gene

Gene SymbolGene NameChr.Allele SymbolAllele NameCommon NamesPromoterDiseases Related to This Gene
FasFas cell surface death receptor19Fastargeted mutation 1, Osaka University Medical School
  • autoimmune lymphoproliferative syndrome type 1(DisGeNET, MedGEN)
    • lacZbeta-galactosidase (E. coli)19
  • autoimmune lymphoproliferative syndrome type 1(DisGeNET, MedGEN)
    • neoneomycin resistance gene (E. coli)19mouse phosphoglycerate kinase promoter (PGK promoter)
  • autoimmune lymphoproliferative syndrome type 1(DisGeNET, MedGEN)

    • Phenotype

    Annotation by Mammalian phenotyhpe ontology
  • abnormal T cell clonal deletion(MP:0005002)

  • abnormal hepatocyte morphology(MP:0000607)

  • abnormal hypersensitivity reaction(MP:0002148)

  • abnormal lymph organ size(MP:0002221)

  • enlarged lymph nodes(MP:0000702)
    • more 16 phenotypes
  • enlarged spleen(MP:0000691)

  • increased B cell number(MP:0005014)

  • increased IgG level(MP:0002493)

  • increased IgG1 level(MP:0008499)

  • increased IgG2a level(MP:0008500)

  • increased IgG2b level(MP:0008501)

  • increased IgG3 level(MP:0008502)

  • increased anti-double stranded DNA antibody level(MP:0004762)

  • increased anti-single stranded DNA antibody level(MP:0004771)

  • increased autoantibody level(MP:0003725)

  • increased leukocyte cell number(MP:0000218)

  • increased lymphocyte cell number(MP:0005013)

  • increased susceptibility to parasitic infection(MP:0005027)

  • liver hyperplasia(MP:0005141)

  • lymphoid hyperplasia(MP:0000688)

  • premature death(MP:0002083)
    • Detailed phenotype data

    Ordering Information

    Donor DNAFas抗原遺伝子欠損マウス(ヘテロ変異体のノックアウトマウス)マーカーとして、E. coli neo、E. coli lacZ, mouse phosphoglycerate kinase promoter (PGK promoter)
    Research applicationApoptosis Research
    Immunology and Inflammation Research
    Specific Term and ConditionsThe RECIPIENT of BIOLOGICAL RESOURCE shall obtain a prior written consent on use of it from the DEPOSITOR. In publishing the research results obtained by use of the BIOLOGICAL RESOURCE, a citation of the following literature(s) designated by the DEPOSITOR is requested. Nature Genetics, 11, 294-300 (1995).RECIPIENT may only use the BIOLOGICAL RESOURCE for non-commercial academic research purpose.
    The RECIPIENT should negotiate with the DEPOSITOR in the case of application for any patents or commercial use with the results from the use of the BIOLOGICAL RESOURCE.
    DepositorShigekazu Nagata (Kyoto University)
    Strain Statusan icon for Frozen spermFrozen sperm
    Strain AvailabilityRecovered litters from cryopreserved sperm (2 to 4 months)
    Cryopreserved sperm (within 1 month)
    Additional Info.Necessary documents for ordering:
    1. Approval form (Japanese / English)
    2. Order form (Japanese / English)
    3. Category I MTA: MTA for distribution with RIKEN BRC (Japanese / English)
    4. Acceptance of responsibility for living modified organism (Japanese / English)
    Lab HP
    Genotyping protocol -PCR-

    BRC mice in Publications

    No Data