Strain Data Sheet
RBRC01459
Strain Information | |
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| Image |  |
| BRC No. | RBRC01459 |
| Type | Transgene |
| Species | Mus musculus |
| Strain name | FVB/N-Tg(P0-cre)1Gth/GvnRbrc |
| Former Common name | P0Cre-A |
| H-2 Haplotype | |
| ES Cell line | |
| Background strain | FVB/N |
| Appearance | albino [a/a B/B C/C] |
| Strain development | Developed by Dr. Marco Giovannini at INSERM, France in 2000. P0Cre transgene fragment consisting of P1 Cre recomnbinase and 1.1 kb rat P0 promoter was injected into the pronuclei of FVB/N fertilized egges. |
| Strain description | FVB/N-Tg(P0-Cre)1Gth. P0Cre contains a transcriptional unit consisting of a Schwann cell specific promoter (myelin protein zero promoter) and Cre recombinase gene. This strain can be used to make a inducible knock-out by crossing with other conditional knock out mice that have floxed genes. P0Cre is a driver mouse that can remove floxed genes only in the myelin of the PNS. |
| Colony maintenance | Sibling Mating |
| References | Genes Dev., 14, 1617-1630 (2000). 10887156 |
Health Report | |
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| Examination Date / Room / Rack | |
Gene | |
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| Gene info | Gene symbolGene nameChr.Allele symbolAllele nameCommon namesPromoter crePhage P1 Cre recombinaseUNcrerat P0 promoter, rabbit beta-globin intron and polyadenylation signal Gene symbolGene nameChr.Allele symbolAllele nameCommon namesPromoter nlsSV40 large T antigen nuclear localization signal (NLS)UNnls |
Ordering Information | |
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| 供与核酸 | rat P0 promoter, Simian virus 40 Large T antigen nuclear localization signal (nls), Phage P1 Cre recombinase, rabbit beta-globin intron and polyadenylation signal |
| Research application | Cre/loxP system |
| 提供条件 | 条件を付加する。 研究成果の公表にあたって寄託者の指定する文献を引用する。Genes & Development, 14, 1617-1630 (2000). 研究成果の公表にあたって謝辞の表明を必要とする。 RECIPIENT shall keep DEPOSITOR apprised of any results obtained from the BIOLOGICAL RESOURCE in the course of the research, as soon as they are available. Moreover, if the research results in a potential invention or a substance that may have potential commercial value (hereinafter referred as to the "Invention") RECIPIENT will promptly disclose this Invention to DEPOSITOR with samples thereof for DEPOSITOR's internal use. RECIPIENT and DEPOSITOR will consult together and agree about the possibility of filing one or more patent application to Invention conceived by one or more employees of Recipients that directly arise out of the research. The Parties will negotiate in good faith the conditions of such patent application according to each party's inventiveness contribution in the Invention. In case of such Invention, patentable or not, reduced in practice or developed in the course of the research that could not have been obtained, reduced to practice or developed but from using the Material and/or Confidential Information, RECIPIENT and DEPOSITOR shall confer with one another as regards licensing and commercialization of such Invention to negotiate in good faith the terms of an institutional agreement as regards said matters. |
| Depositor | Marco Giovannini（INSERM） |
| Strain Status |  凍結胚 凍結精子 |
| Strain Availability | 凍結胚より作出したマウスを2~4ヶ月以内に提供可能 凍結精子を1ヶ月以内に提供可能 凍結胚を1ヶ月以内に提供可能 |
| Additional Info. | Necessary documents for ordering:
Genotyping protocol -PCR- Genetic Background |
BRC mice in Publications |
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Ogawa Y, Eto A, Miyake C, Tsuchida N, Miyake H, Takaku Y, Hagiwara H, Oishi K. Induced Pluripotent Stem Cells Generated from P0-Cre;Z/EG Transgenic Mice. PLoS One 10(9) e0138620(2015) 26382630 Sowa Y, Imura T, Numajiri T, Takeda K, Mabuchi Y, Matsuzaki Y, Nishino K. Adipose stromal cells contain phenotypically distinct adipogenic progenitors derived from neural crest. PLoS One 8(12) e84206(2013) 24391913 |