Strain Data Sheet

RBRC01449

Strain Information

Image
BRC No.RBRC01449
TypeSpontaneous Mutation
SpeciesMus musculus
Strain nameICGNww/Oa
Former Common nameNEP WIL
H-2 Haplotype
ES Cell line
Background strainICR
Appearance
Strain development1991年に国立予防衛生研究所から　ICGN F9 の♀4匹、♂6匹を分与され、大阪大学医学部動物実検施設にて近交化に成功した。ICRでの突然変異に由来し、現在39世代目にあたる。
Strain description若齢においてネフローゼ症候群を発症し、徐々に腎機能を失い、慢性腎不全に至る。野生型のライン。
Colony maintenance
References
Characteristics of mutant mice (ICGN) with spontaneous renal lesions: a new model for human nephrotic syndrome.
A Ogura, T Asano, J Matsuda, K Takano, M Nakagawa, M Fukui
Lab. Anim., 23,　169-174 (1989). 2523501

日本疾患モデル学会記安 9:62 (1993).

Mouse Genome, 91, 876-878 (1993).

[Pathogenesis of spontaneous nephrosis in mice--urinary protein in nephrotic mice].
K Yamada, T Kurosawa, M Okamoto, B F Yue, S Mizuno, M Naiki
Jikken Dobutsu 43:527-534 (1994). 7805796

Morphological studies on the kidney of the spontaneous nephrotic (ICGN) mice in the late stage.
H Tatsumi, S Satoh, M Okamoto, M Nakamura, T Asano, T Kurosawa
Kaibogaku Zasshi 70:96-106 (1995). 7785418

Diffuse glomerulosclerosis without tubular injury does not directly manifest renal dysfunction in nephrotic mice (ICGN strain).
S Mizuno, B F Yue, M Okamoto, Y Horikawa, T Kurosawa
Exp. Nephrol., 5:498-507 (1997). 9438179

Hepatocyte growth factor prevents renal fibrosis and dysfunction in a mouse model of chronic renal disease.
S Mizuno, T Kurosawa, K Matsumoto, Y Mizuno-Horikawa, M Okamoto, T Nakamura
J Clin Invest 101:1827-1834 (1998). 9576745

Angiotensin-converting enzyme inhibitor suppresses tubular expression of platelet-derived growth factor and attenuates progression of tubulo-interstitial fibrosis in a nephrotic mouse model.
S Mizuno, Y Mizuno-Horikawa, M Okamoto, T Kurosawa
Nephron 79:503-504 (1998). 9689182

Preventive effect of ACE inhibitor on interstitial myofibroblast formation and matrix deposition in a nephrotic model.
S Mizuno, Y Horikawa, M Okamoto, T Kurosawa
Ren Fail 20:481-491 (1998). 9606736

Nephrotic mice (ICGN strain): a model of diffuse mesangial sclerosis in infantile nephrotic syndrome.
S Mizuno, Y Mizuno-Horikawa, B F Yue, M Okamoto, T Kurosawa
Am. J. Nephrol., 19:73-82 (1999). 10085455
more 8 references
Linkage mapping of the mouse nephrosis (nep) gene to chromosome 15.
M Okamoto, N Yokoi, T Serikawa, M Tajima, T Kurosawa
J Vet Med Sci 63:1347-1350 (2001). 11789617

Immunohistochemical analysis of molecular events in tubulo-interstitial fibrosis in a mouse model of diffuse mesangial sclerosis (ICGN strain).
S Mizuno, Y Mizuno-Horikawa, T Kurosawa
J Vet Med Sci 63:299-307 (2001). 11307931

Advanced glomerulosclerosis is reversible in nephrotic mice.
Y Mizuno-Horikawa, S Mizuno, S Tamura, T Kurosawa
Biochem. Biophys. Res. Commun., 284:707-713 (2001). 11396960

Protein restriction ameliorates renal tubulointerstitial nephritis and reduces renal transforming growth factor-beta expression in unilateral ureteral obstruction.
Ko Sawashima, Shinya Mizuno, Yoko Mizuno-Horikawa, Tadaaki Kudo, Tsutomu Kurosawa
Exp. Nephrol., 10:7-18 (2002). 11803200

獣医生化学 40:55-61(2004).

Deficiency of the tensin2 gene in the ICGN mouse: an animal model for congenital nephrotic syndrome.
A-Ri Cho, Kozue Uchio-Yamada, Takeshi Torigai, Tomomi Miyamoto, Ichiro Miyoshi, Junichiro Matsuda, Tsutomu Kurosawa, Yasuhiro Kon, Atsushi Asano, Nobuya Sasaki, Takashi Agui
Mamm Genome 17:407-416 (2006). 16688531

The possible involvement of tensin2 in the expression and extension of nephrin by glomerular podocytes in mice.
Takashi Kato, Shinya Mizuno, Makoto Mark Taketo, Tsutomu Miki Kurosawa
Biomed. Res., 29:279-287 (2008). 19129671

Proteinuria-induced chronic kidney disease in the ICGN/Oa mice with a mutation of Tensin2 gene.
Takashi Kato, Tsutomu Miki Kurosawa, Makoto Mark Taketo
Ren Fail 31:229-238 (2009). 19288329

Health Report

Examination Date / Room / Rack

Gene

Gene SymbolGene NameChr.Allele SymbolAllele NameCommon NamesPromoterDiseases Related to This Gene
Tenc1
MGI:1096861		tensin like C1 domain-containing phosphatase15Tenc1

Phenotype

Phenotype annotation from literatures by Mammalian phenotype ontology
  • abnormal intestine morphology (MP:0000477)

  • abnormal kidney cortex morphology (MP:0000521)

  • abnormal kidney morphology (MP:0002135)

  • abnormal renal glomerulus morphology (MP:0005325)

  • abnormal renal/urinary system morphology (MP:0000516)
    • more 17 phenotypes
  • abnormal reproductive system morphology (MP:0002160)

  • albuminuria (MP:0002871)

  • decreased abdominal adipose tissue amount (MP:0008853)

  • decreased circulating total protein level (MP:0005567)

  • decreased hematocrit (MP:0000208)

  • dilated renal tubule (MP:0002705)

  • edema (MP:0001785)

  • enlarged lymph nodes (MP:0000702)

  • glomerulonephritis (MP:0002743)

  • increased blood urea nitrogen level (MP:0005565)

  • increased circulating cholesterol level (MP:0005178)

  • increased urine protein level (MP:0002962)

  • premature death (MP:0002083)

  • reduced fertility (MP:0001921)

  • renal glomerular immunoglobulin deposits (MP:0020519)

  • renal glomerular protein deposits (MP:0020518)

  • small kidney (MP:0002989)
    • Detailed phenotype data

    Ordering Information

    供与核酸
    Research applicationGenetics Research
    Mouse Models for Human Disease
    提供条件利用者は事前に寄託者の提供承諾書を得る。利用目的が寄託者の研究内容に競合することがないとの条件で利用を承諾する。また得られた成果にかかる権利等は事前に内容を伝達し、許諾を受ける。
    Depositor黒澤　努（国立大学法人大阪大学）
    Strain Status凍結胚のアイコン凍結胚
    Strain Availability凍結胚より作出したマウスを2~4ヶ月以内に提供可能
    凍結胚を1ヶ月以内に提供可能
    Additional Info.Necessary documents for ordering:
    1. Approval form (Japanese / English)
    2. Order form (Japanese / English)
    3. Category I MTA: MTA for distribution with RIKEN BRC (Japanese / English)

    Genotyping protocol -PCR-

    BRC mice in Publications

    No Data