Strain Data Sheet

RBRC01447

Strain Information

Image
BRC No.RBRC01447
TypeSpontaneous Mutation
SpeciesMus musculus
Strain nameICGNoe/Oa
Former Common nameNEP Main
H-2 Haplotype
ES Cell line
Background strainICR
Appearance
Strain development
Strain description
Colony maintenance
References
Characteristics of mutant mice (ICGN) with spontaneous renal lesions: a new model for human nephrotic syndrome.
Ogura A, Asano T, Matsuda J, Takano K, Nakagawa M, Fukui M
Lab. Anim., 23,　169-174 (1989). 2523501

日本疾患モデル学会記安 9:62 (1993).

Mouse Genome, 91, 876-878 (1993).

[Pathogenesis of spontaneous nephrosis in mice--urinary protein in nephrotic mice].
Yamada K, Kurosawa T, Okamoto M, Yue B F, Mizuno S, Naiki M
Jikken Dobutsu 43:527-534 (1994). 7805796

Morphological studies on the kidney of the spontaneous nephrotic (ICGN) mice in the late stage.
Tatsumi H, Satoh S, Okamoto M, Nakamura M, Asano T, Kurosawa T
Kaibogaku Zasshi 70:96-106 (1995). 7785418

Diffuse glomerulosclerosis without tubular injury does not directly manifest renal dysfunction in nephrotic mice (ICGN strain).
Mizuno S, Yue B F, Okamoto M, Horikawa Y, Kurosawa T
Exp. Nephrol., 5:498-507 (1997). 9438179

Preventive effect of ACE inhibitor on interstitial myofibroblast formation and matrix deposition in a nephrotic model.
Mizuno S, Horikawa Y, Okamoto M, Kurosawa T
Ren Fail 20:481-491 (1998). 9606736

Angiotensin-converting enzyme inhibitor suppresses tubular expression of platelet-derived growth factor and attenuates progression of tubulo-interstitial fibrosis in a nephrotic mouse model.
Mizuno S, Mizuno-Horikawa Y, Okamoto M, Kurosawa T
Nephron 79:503-504 (1998). 9689182

Hepatocyte growth factor prevents renal fibrosis and dysfunction in a mouse model of chronic renal disease.
Mizuno S, Kurosawa T, Matsumoto K, Mizuno-Horikawa Y, Okamoto M, Nakamura T
J Clin Invest 101:1827-1834 (1998). 9576745

Nephrotic mice (ICGN strain): a model of diffuse mesangial sclerosis in infantile nephrotic syndrome.
Mizuno S, Mizuno-Horikawa Y, Yue B F, Okamoto M, Kurosawa T
Am. J. Nephrol., 19:73-82 (1999). 10085455
more 8 references
Advanced glomerulosclerosis is reversible in nephrotic mice.
Mizuno-Horikawa Y, Mizuno S, Tamura S, Kurosawa T
Biochem. Biophys. Res. Commun., 284:707-713 (2001). 11396960

Immunohistochemical analysis of molecular events in tubulo-interstitial fibrosis in a mouse model of diffuse mesangial sclerosis (ICGN strain).
Mizuno S, Mizuno-Horikawa Y, Kurosawa T
J Vet Med Sci 63:299-307 (2001). 11307931

Linkage mapping of the mouse nephrosis (nep) gene to chromosome 15.
Okamoto M, Yokoi N, Serikawa T, Tajima M, Kurosawa T
J Vet Med Sci 63:1347-1350 (2001). 11789617

Protein restriction ameliorates renal tubulointerstitial nephritis and reduces renal transforming growth factor-beta expression in unilateral ureteral obstruction.
Sawashima K, Mizuno S, Mizuno-Horikawa Y, Kudo T, Kurosawa T
Exp. Nephrol., 10:7-18 (2002). 11803200

獣医生化学 40:55-61(2004).

Deficiency of the tensin2 gene in the ICGN mouse: an animal model for congenital nephrotic syndrome.
Cho A R, Uchio-Yamada K, Torigai T, Miyamoto T, Miyoshi I, Matsuda J, Kurosawa T, Kon Y, Asano A, Sasaki N, Agui T
Mamm Genome 17:407-416 (2006). 16688531

The possible involvement of tensin2 in the expression and extension of nephrin by glomerular podocytes in mice.
Kato T, Mizuno S, Taketo M M, Kurosawa T M
Biomed. Res., 29:279-287 (2008). 19129671

Proteinuria-induced chronic kidney disease in the ICGN/Oa mice with a mutation of Tensin2 gene.
Kato T, Kurosawa T M, Taketo M M
Ren Fail 31:229-238 (2009). 19288329

Health Report

Examination Date / Room / Rack

Gene

Gene SymbolGene NameChr.Allele SymbolAllele NameCommon NamesPromoterDiseases Related to This Gene
Tenc1
MGI:1096861		tensin like C1 domain-containing phosphatase15Tenc1<nph> nephrosis

Phenotype

Annotation by Mammalian phenotyhpe ontology
  • abnormal intestine morphology(MP:0000477)

  • abnormal kidney cortex morphology(MP:0000521)

  • abnormal kidney morphology(MP:0002135)

  • abnormal renal glomerulus morphology(MP:0005325)

  • abnormal renal/urinary system morphology(MP:0000516)
    • more 17 phenotypes
  • abnormal reproductive system morphology(MP:0002160)

  • albuminuria(MP:0002871)

  • decreased abdominal adipose tissue amount(MP:0008853)

  • decreased circulating total protein level(MP:0005567)

  • decreased hematocrit(MP:0000208)

  • dilated renal tubule(MP:0002705)

  • edema(MP:0001785)

  • enlarged lymph nodes(MP:0000702)

  • glomerulonephritis(MP:0002743)

  • increased blood urea nitrogen level(MP:0005565)

  • increased circulating cholesterol level(MP:0005178)

  • increased urine protein level(MP:0002962)

  • premature death(MP:0002083)

  • reduced fertility(MP:0001921)

  • renal glomerular immunoglobulin deposits(MP:0020519)

  • renal glomerular protein deposits(MP:0020518)

  • small kidney(MP:0002989)
    • Detailed phenotype data

    Ordering Information

    Donor DNA
    Research applicationGenetics Research
    Mouse Models for Human Disease
    Specific Term and ConditionsThe RECIPIENT of BIOLOGICAL RESOURCE shall obtain a prior written consent on use of it from the DEPOSITOR. We permit the use of NEP mice on the condition of not competing with the contributor's research and the right etc. to hang to the achieved results need to be transmitted beforehand and obtained our permission
    DepositorTsutomu Kurosawa (Osaka University)
    Strain Statusan icon for Frozen embryosFrozen embryos
    Strain AvailabilityRecovered litters from cryopreserved embryos (2 to 4 months)
    Cryopreserved embryos (within 1 month)
    Additional Info.Necessary documents for ordering:
    1. Approval form (Japanese / English)
    2. Order form (Japanese / English)
    3. Category I MTA: MTA for distribution with RIKEN BRC (Japanese / English)

    Genotyping protocol -PCR-

    BRC mice in Publications

    No Data