Strain Data Sheet

RBRC01446

Strain Information

Image
BRC No.RBRC01446
TypeSpontaneous Mutation
SpeciesMus musculus
Strain nameDDY-Dao1<+>/ConnRbrc
Former Common nameddY/DAO<+> mice
H-2 Haplotype
ES Cell line
Background strain
Appearance
Strain development1983年、1987年、2000年. 長期の海外出張のたび、系統を絶やし、新しく分離しなおした。金野柳一先生、独協医科大学。市販の ddY マウスの集団からスクリーンニングによりD-アミノ酸酸化酵素欠損マウスを分離した時にD-アミノ酸酸化酵素をもっているコントロールとして分離し、兄妹交配を繰り返し、系統を樹立した。雑系の ddY 由来 F21.
Strain descriptionクローズドコロニーddY由来。D-アミノ酸酵素欠損マウスddY/DAO<->の野生型コントロールマウス。統合失調症の研究。Dao1<c> (Dao1<G181R>) allele arose in some of the ddY closed colony strain. The mice with this allele lack the D-amino acid oxidase activity. This strain is useful for study of D-amino acids.
Colony maintenance特別の飼育管理の必要はない。兄妹交配。繁殖効率は良好ですが、時として生まれた子供の面倒をみないことがある。
References
Mouse mutant deficient in D-amino acid oxidase activity.
R Konno, Y Yasumura
Genetics, 103, 277-285 (1983). 6131852

Involvement of D-amino-acid oxidase in D-amino acid utilization in the mouse.
R Konno, Y Yasumura
J. Nutr., 114, 1617-1621 (1984). 6147398

Lack of D-amino-acid oxidase activity causes a specific renal aminoaciduria in the mouse.
R Konno, K Isobe, A Niwa, Y Yasumura
Biochim. Biophys. Acta., 967, 382-390 (1988). 2904279

A simple and rapid method to screen for mutant mice lacking D-amino-acid oxidase activity.
R Konno, Y Yasumura
Lab. Anim. Sci., 38, 292-295 (1988). 2900911

Excessive urinary excretion of methionine in mutant mice lacking D-amino-acid oxidase activity.
R Konno, K Isobe, A Niwa, Y Yasumura
Metabolism, 37, 1139-1142 (1988). 2904113

Presence of D-amino-acid oxidase protein in mutant mice lacking D-amino-acid oxidase activity.
R Konno, K Yamamoto, A Niwa, Y Yasumura
Int. J. Biochem., 23, 1301-1305 (1991). 1686595

A single-base-pair substitution abolishes D-amino-acid oxidase activity in the mouse.
M Sasaki, R Konno, M Nishio, A Niwa, Y Yasumura, J Enami
Biochim. Biophys. Acta., 1139, 315-318 (1992). 1355365

Origin of D-alanine present in urine of mutant mice lacking D-amino-acid oxidase activity.
R Konno, T Oowada, A Ozaki, T Iida, A Niwa, Y Yasumura, T Mizutani
Am. J. Physiol., 265, G699-G703 (1993). 7901999

MouseD-amino-acid oxidase gene: Restriction fragment length polymorphism among mouse strains.
R Konno, M Sasaki, M Shinohara, J Enami, A Niwa
Amino Acids, 10, 133-143 (1996). 24178475

D-amino-acid oxidase is not present in the mouse liver.
R Konno, M Sasaki, S Asakura, K Fukui, J Enami, A Niwa
Biochim. Biophys. Acta., 1335, 173-181 (1997). 9133654
more 7 references
Nephrotoxicity of D-proparglyglycine in mice.
R Konno, M Ikeda, K Yamaguchi, Y Ueda, A Niwa
Arch Toxicol., 74, 473-479 (2000). 11097385

Exaggerated responses to chronic nociceptive stimuli and enhancement of N-methyl-D-aspartate receptor-mediated synaptic transmission in mutant mice lacking D-amino-acid oxidase.
K Wake, H Yamazaki, S Hanzawa, R Konno, H Sakio, A Niwa, Y Hori
Neurosci. Lett., 297, 25-28 (2001). 11114476

Determination of free D-proline and D-leucine in the brains of mutant mice lacking D-amino acid oxidase activity.
K Hamase, T Inoue, A Morikawa, R Konno, K Zaitsu
Anal. Biochem., 298, 253-258 (2001). 11700980

Determination of free D-aspartic acid, D-serine and D-alanine in the brain of mutant mice lacking D-amino acid oxidase activity.
A Morikawa, K Hamase, T Inoue, R Konno, A Niwa, K Zaitsu
J. Chromatogr. B, 757, 119-125 (2001). 11419736

Effects of endogenous agonists, glycine and D-serine, on in vivo specific binding of [11C]L-703,717, a PET radioligand for the glycine-binding site of NMDA receptors.
Terushi Haradahira, Takashi Okauchi, Jun Maeda, Ming-Rong Zhang, Toru Nishikawa, Ryouichi Konno, Kazutoshi Suzuki, Tetsuya Suhara
Synapse, 50, 130-136 (2003). 12923815

Role of renal D-amino-acid oxidase in pharmacokinetics of D-leucine.
Hiroshi Hasegawa, Takehisa Matsukawa, Yoshihiko Shinohara, Ryuichi Konno, Takao Hashimoto
Am. J. Physiol. Endocrinol. Metab., 287, E160-E165 (2004). 15026304

Mice lacking D-amino acid oxidase activity display marked attenuation of stereotypy and ataxia induced by MK-801.
Atsushi Hashimoto, Masanobu Yoshikawa, Akira Niwa, Ryuichi Konno
Brain Res., 1033, 210-215 (2005). 15694926

Health Report

Examination Date / Room / Rack

Gene

Gene SymbolGene NameChr.Allele SymbolAllele NameCommon NamesPromoterDiseases Related to This Gene
Dao
MGI:94859		D-amino acid oxidase5Dao

Phenotype

Phenotype annotation from literatures by Mammalian phenotype ontology
  • normal phenotype (MP:0002873)
    • Detailed phenotype data

    Ordering Information

    供与核酸
    Research applicationCell Biology Research
    Genetics Research
    Neurobiology Research
    Toxicology Research
    提供条件条件を付加しない。
    Depositor金野　柳一（獨協医科大学）
    Strain Status凍結胚のアイコン凍結胚
    Strain Availability凍結胚より作出したマウスを2~4ヶ月以内に提供可能
    Additional Info.Necessary documents for ordering:
    1. Approval form (Japanese / English)
    2. Order form (Japanese / English)
    3. Category I MTA: MTA for distribution with RIKEN BRC (Japanese / English)

    Genotyping protocol -PCR-

    BRC mice in Publications

    No Data