Strain Data Sheet

RBRC01446

update : 2026-03-19

Strain Information
Image
BRC No.	RBRC01446
Type	Spontaneous Mutation
Species	Mus musculus
Strain name	DDY-Dao1<+>/ConnRbrc
Former Common name	ddY/DAO<+> mice
H-2 Haplotype
ES Cell line
Background strain
Appearance
Strain development	Derived from ddY closed colony.
Strain description	Dao1<c> (Dao1<G181R>) allele arose in some of the ddY closed colony strain. The mice with this allele lack the D-amino acid oxidase activity. This strain is useful for study of D-amino acids.
Colony maintenance	Sibling Mating
References	Mouse mutant deficient in D-amino acid oxidase activity. R Konno, Y Yasumura Genetics, 103, 277-285 (1983). 6131852 Involvement of D-amino-acid oxidase in D-amino acid utilization in the mouse. R Konno, Y Yasumura J. Nutr., 114, 1617-1621 (1984). 6147398 A simple and rapid method to screen for mutant mice lacking D-amino-acid oxidase activity. R Konno, Y Yasumura Lab. Anim. Sci., 38, 292-295 (1988). 2900911 Lack of D-amino-acid oxidase activity causes a specific renal aminoaciduria in the mouse. R Konno, K Isobe, A Niwa, Y Yasumura Biochim. Biophys. Acta., 967, 382-390 (1988). 2904279 Excessive urinary excretion of methionine in mutant mice lacking D-amino-acid oxidase activity. R Konno, K Isobe, A Niwa, Y Yasumura Metabolism, 37, 1139-1142 (1988). 2904113 Presence of D-amino-acid oxidase protein in mutant mice lacking D-amino-acid oxidase activity. R Konno, K Yamamoto, A Niwa, Y Yasumura Int. J. Biochem., 23, 1301-1305 (1991). 1686595 A single-base-pair substitution abolishes D-amino-acid oxidase activity in the mouse. M Sasaki, R Konno, M Nishio, A Niwa, Y Yasumura, J Enami Biochim. Biophys. Acta., 1139, 315-318 (1992). 1355365 Origin of D-alanine present in urine of mutant mice lacking D-amino-acid oxidase activity. R Konno, T Oowada, A Ozaki, T Iida, A Niwa, Y Yasumura, T Mizutani Am. J. Physiol., 265, G699-G703 (1993). 7901999 MouseD-amino-acid oxidase gene: Restriction fragment length polymorphism among mouse strains. R Konno, M Sasaki, M Shinohara, J Enami, A Niwa Amino Acids, 10, 133-143 (1996). 24178475 D-amino-acid oxidase is not present in the mouse liver. R Konno, M Sasaki, S Asakura, K Fukui, J Enami, A Niwa Biochim. Biophys. Acta., 1335, 173-181 (1997). 9133654 more 7 references Nephrotoxicity of D-proparglyglycine in mice. R Konno, M Ikeda, K Yamaguchi, Y Ueda, A Niwa Arch Toxicol., 74, 473-479 (2000). 11097385 Determination of free D-proline and D-leucine in the brains of mutant mice lacking D-amino acid oxidase activity. K Hamase, T Inoue, A Morikawa, R Konno, K Zaitsu Anal. Biochem., 298, 253-258 (2001). 11700980 Exaggerated responses to chronic nociceptive stimuli and enhancement of N-methyl-D-aspartate receptor-mediated synaptic transmission in mutant mice lacking D-amino-acid oxidase. K Wake, H Yamazaki, S Hanzawa, R Konno, H Sakio, A Niwa, Y Hori Neurosci. Lett., 297, 25-28 (2001). 11114476 Determination of free D-aspartic acid, D-serine and D-alanine in the brain of mutant mice lacking D-amino acid oxidase activity. A Morikawa, K Hamase, T Inoue, R Konno, A Niwa, K Zaitsu J. Chromatogr. B, 757, 119-125 (2001). 11419736 Effects of endogenous agonists, glycine and D-serine, on in vivo specific binding of [11C]L-703,717, a PET radioligand for the glycine-binding site of NMDA receptors. Terushi Haradahira, Takashi Okauchi, Jun Maeda, Ming-Rong Zhang, Toru Nishikawa, Ryouichi Konno, Kazutoshi Suzuki, Tetsuya Suhara Synapse, 50, 130-136 (2003). 12923815 Role of renal D-amino-acid oxidase in pharmacokinetics of D-leucine. Hiroshi Hasegawa, Takehisa Matsukawa, Yoshihiko Shinohara, Ryuichi Konno, Takao Hashimoto Am. J. Physiol. Endocrinol. Metab., 287, E160-E165 (2004). 15026304 Mice lacking D-amino acid oxidase activity display marked attenuation of stereotypy and ataxia induced by MK-801. Atsushi Hashimoto, Masanobu Yoshikawa, Akira Niwa, Ryuichi Konno Brain Res., 1033, 210-215 (2005). 15694926

Health Report
Examination Date / Room / Rack

Gene
Gene Symbol	Gene Name	Chr.	Allele Symbol	Allele Name	Common Names	Promoter	Diseases Related to This Gene
Dao MGI:94859	D-amino acid oxidase	5	Dao

Phenotype
Phenotype annotation from literatures by Mammalian phenotype ontology	normal phenotype (MP:0002873)
Detailed phenotype data

Ordering Information
Donor DNA
Research application	Cell Biology Research Genetics Research Neurobiology Research Toxicology Research
Specific Term and Conditions	No specific terms and conditions. (The DEPOSITOR waives its own rights under any patents, intellectual property, or other proprietary rights with respect to the results to be obtained by use of the BIOLOGICAL RESOURCE.)
Depositor	Ryuichi, Konno (Dokkyo Medical University)
Strain Status	Frozen embryos
Strain Availability	Recovered litters from cryopreserved embryos (2 to 4 months)
Additional Info.	Necessary documents for ordering: Approval form (Japanese / English) Order form (Japanese / English) Category I MTA: MTA for distribution with RIKEN BRC (Japanese / English) Genotyping protocol -PCR-

BRC mice in Publications

No Data