Strain Data Sheet
RBRC01445
Strain Information | |
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| Image |  |
| BRC No. | RBRC01445 |
| Type | Spontaneous Mutation |
| Species | Mus musculus |
| Strain name | DDY-Dao<G181R>/ConnRbrc |
| Former Common name | ddY/DAO<-> mice |
| H-2 Haplotype | |
| ES Cell line | |
| Background strain | |
| Appearance | albino [c/c] |
| Strain development | Spontaneous mutation arose in the ddY closed colony. Developed by Dr. Ryuichi Konno, Dokkyo University. |
| Strain description | This mutant mice have a missense mutation (Gly181Arg) in DAO gene. The mice with this mutant allele lack the D-amino acid oxidase activity. The levels of D-serine in the cerebellum and rostral brain of mutant mice are higher than those of normal (Dao1+/+) mice. The mutant mice display a decrease of stereotypy and ataxia induced by NMDA receptor antagonists. This strain is useful for study of schizophrenia. |
| Colony maintenance | Sibling Mating (Homozygote x Homozygote)Homozygous mutant mice are viable and fertile. |
| References | Mouse mutant deficient in D-amino acid oxidase activity. R Konno, Y Yasumura Genetics, 103, 277-285 (1983). 6131852Involvement of D-amino-acid oxidase in D-amino acid utilization in the mouse. R Konno, Y Yasumura J. Nutr., 114, 1617-1621 (1984). 6147398A simple and rapid method to screen for mutant mice lacking D-amino-acid oxidase activity. R Konno, Y Yasumura Lab. Anim. Sci., 38, 292-295 (1988). 2900911Excessive urinary excretion of methionine in mutant mice lacking D-amino-acid oxidase activity. R Konno, K Isobe, A Niwa, Y Yasumura Metabolism, 37, 1139-1142 (1988). 2904113Lack of D-amino-acid oxidase activity causes a specific renal aminoaciduria in the mouse. R Konno, K Isobe, A Niwa, Y Yasumura Biochim. Biophys. Acta., 967, 382-390 (1988). 2904279Presence of D-amino-acid oxidase protein in mutant mice lacking D-amino-acid oxidase activity. R Konno, K Yamamoto, A Niwa, Y Yasumura Int. J. Biochem., 23, 1301-1305 (1991). 1686595A single-base-pair substitution abolishes D-amino-acid oxidase activity in the mouse. M Sasaki, R Konno, M Nishio, A Niwa, Y Yasumura, J Enami Biochim. Biophys. Acta., 1139, 315-318 (1992). 1355365Origin of D-alanine present in urine of mutant mice lacking D-amino-acid oxidase activity. R Konno, T Oowada, A Ozaki, T Iida, A Niwa, Y Yasumura, T Mizutani Am. J. Physiol., 265, G699-G703 (1993). 7901999MouseD-amino-acid oxidase gene: Restriction fragment length polymorphism among mouse strains. R Konno, M Sasaki, M Shinohara, J Enami, A Niwa Amino Acids, 10, 133-143 (1996). 24178475D-amino-acid oxidase is not present in the mouse liver. R Konno, M Sasaki, S Asakura, K Fukui, J Enami, A Niwa Biochim. Biophys. Acta., 1335, 173-181 (1997). 9133654more 7 referencesNephrotoxicity of D-proparglyglycine in mice. R Konno, M Ikeda, K Yamaguchi, Y Ueda, A Niwa Arch Toxicol., 74, 473-479 (2000). 11097385Determination of free D-aspartic acid, D-serine and D-alanine in the brain of mutant mice lacking D-amino acid oxidase activity. A Morikawa, K Hamase, T Inoue, R Konno, A Niwa, K Zaitsu J. Chromatogr. B, 757, 119-125 (2001). 11419736Exaggerated responses to chronic nociceptive stimuli and enhancement of N-methyl-D-aspartate receptor-mediated synaptic transmission in mutant mice lacking D-amino-acid oxidase. K Wake, H Yamazaki, S Hanzawa, R Konno, H Sakio, A Niwa, Y Hori Neurosci. Lett., 297, 25-28 (2001). 11114476Determination of free D-proline and D-leucine in the brains of mutant mice lacking D-amino acid oxidase activity. K Hamase, T Inoue, A Morikawa, R Konno, K Zaitsu Anal. Biochem., 298, 253-258 (2001). 11700980Effects of endogenous agonists, glycine and D-serine, on in vivo specific binding of [11C]L-703,717, a PET radioligand for the glycine-binding site of NMDA receptors. Terushi Haradahira, Takashi Okauchi, Jun Maeda, Ming-Rong Zhang, Toru Nishikawa, Ryouichi Konno, Kazutoshi Suzuki, Tetsuya Suhara Synapse, 50, 130-136 (2003). 12923815Role of renal D-amino-acid oxidase in pharmacokinetics of D-leucine. Hiroshi Hasegawa, Takehisa Matsukawa, Yoshihiko Shinohara, Ryuichi Konno, Takao Hashimoto Am. J. Physiol. Endocrinol. Metab., 287, E160-E165 (2004). 15026304Mice lacking D-amino acid oxidase activity display marked attenuation of stereotypy and ataxia induced by MK-801. Atsushi Hashimoto, Masanobu Yoshikawa, Akira Niwa, Ryuichi Konno Brain Res., 1033, 210-215 (2005). 15694926 |
Health Report | |
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| Examination Date / Room / Rack | |
Gene | |||||||
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| Gene Symbol | Gene Name | Chr. | Allele Symbol | Allele Name | Common Names | Promoter | Diseases Related to This Gene |
| Dao1 MGI:94859 | D-amino acid oxidase 1 | 5 | Dao1<G181R> | ||||
Phenotype | |
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| Phenotype annotation from literatures by Mammalian phenotype ontology | more 8 phenotypes |
| Detailed phenotype data | |
Ordering Information | |
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| Donor DNA | |
| Research application | Cell Biology Research Genetics Research Neurobiology Research Toxicology Research |
| Specific Term and Conditions | No specific terms and conditions. (The DEPOSITOR waives its own rights under any patents, intellectual property, or other proprietary rights with respect to the results to be obtained by use of the BIOLOGICAL RESOURCE.) |
| Depositor | Ryuichi, Konno (Dokkyo Medical University) |
| Strain Status |  Frozen embryos |
| Strain Availability | Recovered litters from cryopreserved embryos (2 to 4 months) Cryopreserved embryos (within 1 month) |
| Additional Info. | Necessary documents for ordering:
Genotyping protocol -PCR- |
BRC mice in Publications |
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| No Data |