Strain Data Sheet



BRC No.RBRC01395
SpeciesMus musculus
Strain nameC57BL/6-Tg(tetO-AML1/MTG8)1/Rbrc
Former Common nameTOAM8G mice
H-2 Haplotype
ES Cell line
Background strain
Strain developmentDeveloped by Dr. Kiwamu Akagi at 1999. The human AML1-MTG8 chimeric gene was injected into C57BL/6 fertilized eggs.
Strain descriptionThis transgenic mice express a AML1-MTG8 chimeric gene that is activated by the TetR-transactivator. This strain is useful for model mouse of leukemia.
Colony maintenance

Health Report

Examination Date / Room / Rack


Gene info
Gene symbolGene nameChr.Allele symbolAllele nameCommon namesPromoter
CBFA2T1HCBFA2T1 identified gene homolog (human)UNCBFA2T1HETO, MTG8

Gene symbolGene nameChr.Allele symbolAllele nameCommon namesPromoter
RUNX1runt related transcription factor 1 (human)UNRUNX1AML1, Cbfa2, Pebp2a2, runt domain, alpha subunit 2


Donor DNAhuman CMV mini promoter with heptamerized tet-operators upstream, rabbit beta-globin poly A, human AML1-MTG8 cDNA
Research applicationTet system
Specific Term and ConditionsThe RECIPIENT of BIOLOGICAL RESOURCE shall obtain a prior written consent on use of it from the DEPOSITOR. The RECIPIENT agrees to include the DEPOSITOR/DEVELOPER as a co-author in
any publications resulted by the use of the BIOLOGICAL RESOURCE during the
first 2 years after deposition by the DEPOSITOR to the RIKEN BRC.
DepositorKiwamu AKAGI (Saitama Cancer Center)
Strain Statusan icon for Frozen embryosFrozen embryos
Strain AvailabilityRecovered litters from cryopreserved embryos (2 to 4 months)
Cryopreserved embryos (within 1 month)
Additional Info.Necessary documents for ordering:
  1. Approval form (Japanese / English)
  2. Order form (Japanese / English)
  3. Category I MTA: MTA for distribution with RIKEN BRC (Japanese / English)
  4. Acceptance of responsibility for living modified organism (Japanese / English)

Genotyping protocol -PCR-

BRC mice in Publications

No Data