Strain Information | |
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Image | |
BRC No. | RBRC01351 |
Type | Targeted Mutation Congenic |
Species | Mus musculus |
Strain name | B6.129S-Grm2<tm1Nak>/NakRbrc |
Former Common name | C57BL/6-Grm2 tm (Nov.2011), GluR2 KO, mGluR2 KO |
H-2 Haplotype | |
ES Cell line | CCE/EK.CCE [129S/SvEv-Gpi1<c>] |
Background strain | |
Appearance | black [a/a B/B C/C] |
Strain development | C57BL/6系統(substrain不明)で8世代、その後C57BL/6N(チャールズリバー)で12世代戻し交配を行った。 |
Strain description | mGluR2ノックアウトマウス。コカインへの依存行動が亢進している。行動の異常がある |
Colony maintenance | 繁殖効率A特になし |
References | Proc. Natl. Acad. Sci. USA, 102, 4170-4175 (1996). 15753323 Science, 273, 645-647 (1996). 8662555 |
Health Report | |
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Examination Date / Room / Rack |
Gene | |
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Gene info | Gene symbolGene nameChr.Allele symbolAllele nameCommon namesPromoter Grm2G protein-coupled receptor, family C, group 1, member B9Grm2<tm1Nak>targeted mutation 1, Shigetada Nakanishi4930441L02Rik, Grm2, mGluR2 Gene symbolGene nameChr.Allele symbolAllele nameCommon namesPromoter neoneomycin resistance gene (E. coli)9neo; neomycin;herpes simplex virus thymidine kinase promoter (HSV tk promoter) |
Ordering Information | |
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供与核酸 | herpes simplex virus thymidine kinase promoter (HSV tk promoter), E. coli neo, mouse glutamate receptor metabotropic 2 genomic DNA |
Research application | Neurobiology Research |
提供条件 | 条件を付加する。利用者は事前に寄託者の提供承諾書を得る。 研究成果の公表にあたって寄託者の指定する文献を引用する。Science, 273, 645-647 (1996). Proc Natl Acad Sci USA, 102, 4170-4175 (2005). 研究成果の公表にあたって謝辞の表明を必要とする。 必ず提供承諾書を必要とする。 |
Depositor | 中西 重忠(国立大学法人京都大学) |
Strain Status | 凍結胚 凍結精子 |
Strain Availability | 凍結胚より作出したマウスを2~4ヶ月以内に提供可能 凍結精子を1ヶ月以内に提供可能 凍結胚を1ヶ月以内に提供可能 |
Additional Info. | Necessary documents for ordering:
Genotyping protocol -PCR- |
BRC mice in Publications |
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Fribourg M, Moreno JL, Holloway T, Provasi D, Baki L, Mahajan R, Park G, Adney SK, Hatcher C, Eltit JM, Ruta JD, Albizu L, Li Z, Umali A, Shim J, Fabiato A, MacKerell AD Jr, Brezina V, Sealfon SC, Filizola M, González-Maeso J, Logothetis DE. Decoding the signaling of a GPCR heteromeric complex reveals a unifying mechanism of action of antipsychotic drugs. Cell 147(5) 1011-23(2011) 22118459 Moreno JL, Muguruza C, Umali A, Mortillo S, Holloway T, Pilar-Cuéllar F, Mocci G, Seto J, Callado LF, Neve RL, Milligan G, Sealfon SC, López-Giménez JF, Meana JJ, Benson DL, González-Maeso J. Identification of three residues essential for 5-hydroxytryptamine 2A-metabotropic glutamate 2 (5-HT2A·mGlu2) receptor heteromerization and its psychoactive behavioral function. J Biol Chem 287(53) 44301-19(2012) 23129762 Kim H, Lee Y, Park JY, Kim JE, Kim TK, Choi J, Lee JE, Lee EH, Kim D, Kim KS, Han PL. Loss of Adenylyl Cyclase Type-5 in the Dorsal Striatum Produces Autistic-Like Behaviors. Mol Neurobiol 54(10) 7994-8008(2017) 27878759 Moreno JL, Holloway T, Rayannavar V, Sealfon SC, González-Maeso J. Chronic treatment with LY341495 decreases 5-HT(2A) receptor binding and hallucinogenic effects of LSD in mice. Neurosci Lett 536 69-73(2013) 23333599 Moreno JL, Holloway T, Albizu L, Sealfon SC, González-Maeso J. Metabotropic glutamate mGlu2 receptor is necessary for the pharmacological and behavioral effects induced by hallucinogenic 5-HT2A receptor agonists. Neurosci Lett 493(3) 76-9(2011) 21276828 Moreno JL, Miranda-Azpiazu P, García-Bea A, Younkin J, Cui M, Kozlenkov A, Ben-Ezra A, Voloudakis G, Fakira AK, Baki L, Ge Y, Georgakopoulos A, Morón JA, Milligan G, López-Giménez JF, Robakis NK, Logothetis DE, Meana JJ, González-Maeso J. Allosteric signaling through an mGlu2 and 5-HT2A heteromeric receptor complex and its potential contribution to schizophrenia. Sci Signal 9(410) ra5(2016) 26758213 |