Strain Data Sheet

RBRC01342

Strain Information

Image
BRC No.RBRC01342
TypeTransgeneCartagena
SpeciesMus musculus
Strain nameC57BL/6J-Tg(Emx1-cre)1Ito/ItoRbrc
Former Common nameEmx1-Cre Tg1
H-2 Haplotype
ES Cell line
Background strainC57BL/6JJcl
Appearanceblack [a/a B/B C/C]
Strain development理化学研究所脳科学総合研究センター・岩里琢治、糸原重美。C57BL/6J受精卵へトランスジーンのインジェクションにより作出。C57BL/6背景。
Strain descriptionEmx1-creトランスジェニックマウス。ライン1 (RBRC01342) 、ライン2 (RBRC01343) 、およびライン3 (RBRC01344) があり。ライン3の終脳は野生型と比較してやや小さい (重量で約83％) 。Emx1遺伝子の内在生発現特性を最も反映している系統はEmx1-creノックインマウス (delta neo型) (RBRC01345) 。
Colony maintenanceCarrier x Noncarrier [C57BL/6JJcl]
ReferencesGenesis, 38, 130-138 (2004). 15048810

Health Report

Examination Date / Room / Rack

Gene

Gene info
Gene symbolGene nameChr.Allele symbolAllele nameCommon namesPromoter
crePhage P1 Cre recombinaseUNcremouse Emx1 (Drosophila homeobox gene empty spiracles (Ems) mouse homolog) promoter, SV40 poly A

Gene symbolGene nameChr.Allele symbolAllele nameCommon namesPromoter
nlsSV40 large T antigen nuclear localization signal (NLS)UNnls

Ordering Information

供与核酸mouse Emx1 (Drosophila homeobox gene empty spiracles (Ems) mouse homolog) promoter, Simian virus 40 Large T antigen nuclear localization signal (NLS), phage P1 Cre recombinase, SV40 poly A
Research applicationCre/loxP system
提供条件条件を付加する。
研究成果の公表にあたって寄託者の指定する文献を引用する。Genesis, 38, 130-138 (2004).
Depositor糸原　重美（独立行政法人理化学研究所）
Strain Status凍結胚のアイコン凍結胚
凍結精子のアイコン凍結精子
Strain Availability凍結胚より作出したマウスを2~4ヶ月以内に提供可能
凍結精子を1ヶ月以内に提供可能
凍結胚を1ヶ月以内に提供可能
Additional Info.Necessary documents for ordering:
  1. Order form (Japanese / English)
  2. Category I MTA: MTA for distribution with RIKEN BRC (Japanese / English)
  3. Acceptance of responsibility for living modified organism (Japanese / English)

Genotyping protocol -PCR-
Mouse of the Month June 2006

BRC mice in Publications

Pearson CA, Moore DM, Tucker HO, Dekker JD, Hu H, Miquelajáuregui A, Novitch BG.
Foxp1 Regulates Neural Stem Cell Self-Renewal and Bias Toward Deep Layer Cortical Fates.
Cell Rep 30(6) 1964-1981.e3(2020) 32049024

Chen CM, Wang HY, You LR, Shang RL, Liu FC.
Expression analysis of an evolutionarily conserved metallophosphodiesterase gene, Mpped1, in the normal and beta-catenin-deficient malformed dorsal telencephalon.
Dev Dyn 239(6) 1797-806(2010) 20503375

Buth JE, Dyevich CE, Rubin A, Wang C, Gao L, Marks T, Harrison MR, Kong JH, Ross ME, Novitch BG, Pearson CA.
Foxp1 suppresses cortical angiogenesis and attenuates HIF-1alpha signaling to promote neural progenitor cell maintenance.
EMBO Rep (2024) 38600346