Strain Data Sheet



BRC No.RBRC01265
SpeciesMus musculus
Strain nameSM.A-t2dm2saR1B
Former Common name
H-2 Haplotype
ES Cell line
Background strain
Appearanceblack [a/a B/B C/C]
Strain developmentThis strain carries diabetes-related loci on Chr2 introduced by backcrossing from A/J to SM/J. This strain is used to understand the complex gene-gene interaction and as a model of human type 2 diabetes. This SM.A-t2dm2saR1A congenic strain was produced by introduction of the region between D2Mit11 and D2Mit102 of A/J onto the SM/J.
Strain descriptionDeveloped by Drs. Misato Kobayashi and Fumihiko Horio at Nagoya University in 2003. This congenic strain was produced by backcrossing A/J to SM/J.
Colony maintenanceSibling Mating (Homozygote x Homozygote)
ReferencesDiabetes, 52, 180-186 (2003). 12502510
Diabetologia, 49(3):486-495 (2006). 16447060

Health Report

Examination Date / Room / Rack


Gene info
Gene symbolGene nameChr.Allele symbolAllele nameCommon namesPromoter
t2dm2satype 2 diabetes mellitus 22t2dm2sa<A/J>


Donor DNA
Research applicationDiabetes and Obesity Research
Specific Term and ConditionsThe RECIPIENT of BIOLOGICAL RESOURCE shall obtain a prior written consent on use of it from the DEPOSITOR. In publishing the research results obtained by use of the BIOLOGICAL RESOURCE, a citation of the following literature(s) designated by the DEPOSITOR is requested. Diabetologia, 49,486-495 (2006).In publishing the research results to be obtained by use of the BIOLOGICAL RESOURCE, an acknowledgment to the DEPOSITOR is requested. The RECIPIENT must contact the DEPOSITOR in the case of application for any patents or commercial use based on the results from the use of the BIOLOGICAL RESOURCE.The RECIPIENT agrees to use this BIOLOGICAL RESOURCE as a collaboration with the DEPOSITOR.
DepositorFumihiko Horio (Nagoya University)
Strain Statusan icon for Frozen embryosFrozen embryos
Strain AvailabilityRecovered litters from cryopreserved embryos (2 to 4 months)
Cryopreserved embryos (within 1 month)
Additional Info.Necessary documents for ordering:
  1. Approval form (Japanese / English)
  2. Order form (Japanese / English)
  3. Category I MTA: MTA for distribution with RIKEN BRC (Japanese / English)
Lab HP (Japanese)

BRC mice in Publications

No Data