Strain Data Sheet

RBRC01265

Strain Information

Image
BRC No.RBRC01265
TypeCongenic
SpeciesMus musculus
Strain nameSM.A-t2dm2saR1B
Former Common name
H-2 Haplotype
ES Cell line
Background strain
Appearanceblack [a/a B/B C/C]
Strain developmentThis strain carries diabetes-related loci on Chr2 introduced by backcrossing from A/J to SM/J. This strain is used to understand the complex gene-gene interaction and as a model of human type 2 diabetes. This SM.A-t2dm2saR1A congenic strain was produced by introduction of the region between D2Mit11 and D2Mit102 of A/J onto the SM/J.
Strain descriptionDeveloped by Drs. Misato Kobayashi and Fumihiko Horio at Nagoya University in 2003. This congenic strain was produced by backcrossing A/J to SM/J.
Colony maintenanceSibling Mating (Homozygote x Homozygote)
References
Combinations of nondiabetic parental genomes elicit impaired glucose tolerance in mouse SMXA recombinant inbred strains.
Kobayashi M, Ohno T, Tsuji A, Nishimura M, Horio F
Diabetes, 52, 180-186 (2003). 12502510

Major quantitative trait locus on chromosome 2 for glucose tolerance in diabetic SMXA-5 mouse established from non-diabetic SM/J and A/J strains.
Kobayashi M, Io F, Kawai T, Kumazawa M, Ikegami H, Nishimura M, Ohno T, Horio F
Diabetologia, 49(3):486-495 (2006). 16447060

Health Report

Examination Date / Room / Rack

Gene

Gene SymbolGene NameChr.Allele SymbolAllele NameCommon NamesPromoterDiseases Related to This Gene
t2dm2sa type 2 diabetes mellitus 22t2dm2sa<A/J>

Phenotype

Annotation by Mammalian phenotyhpe ontology
  • abnormal nursing(MP:0001382)

  • impaired glucose tolerance(MP:0005293)

  • increased body mass index(MP:0006087)

  • increased body weight(MP:0001260)

  • increased circulating glucose level(MP:0005559)
    • more 2 phenotypes
  • increased circulating insulin level(MP:0002079)

  • increased total body fat amount(MP:0010024)
    • Detailed phenotype data

    Ordering Information

    Donor DNA
    Research applicationDiabetes and Obesity Research
    covid19_progression
    Specific Term and ConditionsThe RECIPIENT of BIOLOGICAL RESOURCE shall obtain a prior written consent on use of it from the DEPOSITOR. In publishing the research results obtained by use of the BIOLOGICAL RESOURCE, a citation of the following literature(s) designated by the DEPOSITOR is requested. Diabetologia, 49,486-495 (2006). In publishing the research results to be obtained by use of the BIOLOGICAL RESOURCE, an acknowledgment to the DEPOSITOR is requested. The RECIPIENT must contact the DEPOSITOR in the case of application for any patents or commercial use based on the results from the use of the BIOLOGICAL RESOURCE.The RECIPIENT agrees to use this BIOLOGICAL RESOURCE as a collaboration with the DEPOSITOR.
    DepositorFumihiko Horio (Nagoya University)
    Strain Statusan icon for Frozen embryosFrozen embryos
    Strain AvailabilityRecovered litters from cryopreserved embryos (2 to 4 months)
    Cryopreserved embryos (within 1 month)
    Additional Info.Necessary documents for ordering:
    1. Approval form (Japanese / English)
    2. Order form (Japanese / English)
    3. Category I MTA: MTA for distribution with RIKEN BRC (Japanese / English)
    Lab HP (Japanese)

    BRC mice in Publications

    No Data