Strain Information | |
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Image | |
BRC No. | RBRC01264 |
Type | Congenic |
Species | Mus musculus |
Strain name | SM.A-t2dm2saR1A |
Former Common name | |
H-2 Haplotype | |
ES Cell line | |
Background strain | |
Appearance | |
Strain development | Developed by Fumihiko Horio, Graduate School of Bioagricultural Sciences, Nagoya University in 2003. |
Strain description | This strain carries diabetes-related loci from Chr 2 of A/J backcrossed to SM/J. This strain is thought to carry a causative gene of diabetes in the integration region originating from A/J on chromosome 18. This strain exhibits a clear diabetes phenotype, compared with a control strain. This SM.A-t2dm2saR1A congenic strain was produced by backcrossing of the region between D2Mit11 to D2Mit37 of A/J onto the SM/J. |
Colony maintenance | |
References | Combinations of nondiabetic parental genomes elicit impaired glucose tolerance in mouse SMXA recombinant inbred strains. Kobayashi M, Ohno T, Tsuji A, Nishimura M, Horio F Diabetes, 52, 180-186 (2003). 12502510Major quantitative trait locus on chromosome 2 for glucose tolerance in diabetic SMXA-5 mouse established from non-diabetic SM/J and A/J strains. Kobayashi M, Io F, Kawai T, Kumazawa M, Ikegami H, Nishimura M, Ohno T, Horio F Diabetologia, 49(3):486-495 (2006). 16447060 |
Health Report | |
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Examination Date / Room / Rack |
Gene | |||||||
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Gene Symbol | Gene Name | Chr. | Allele Symbol | Allele Name | Common Names | Promoter | Diseases Related to This Gene |
t2dm2sa | type 2 diabetes mellitus 2 | 2 | t2dm2sa |
Phenotype | |
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Annotation by Mammalian phenotyhpe ontology | more 1 phenotypes |
Detailed phenotype data |
Ordering Information | |
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Donor DNA | |
Research application | Diabetes and Obesity Research covid19_progression |
Specific Term and Conditions | The RECIPIENT of BIOLOGICAL RESOURCE shall obtain a prior written consent on use of it from the DEPOSITOR. In publishing the research results obtained by use of the BIOLOGICAL RESOURCE, a citation of the following literature(s) designated by the DEPOSITOR is requested. Diabetologia, 49,486-495 (2006). In publishing the research results to be obtained by use of the BIOLOGICAL RESOURCE, an acknowledgment to the DEPOSITOR is requested. The RECIPIENT must contact the DEPOSITOR in the case of application for any patents or commercial use based on the results from the use of the BIOLOGICAL RESOURCE.The RECIPIENT agrees to use this BIOLOGICAL RESOURCE as a collaboration with the DEPOSITOR. |
Depositor | Fumihiko Horio (Nagoya University) |
Strain Status | Frozen embryos |
Strain Availability | Recovered litters from cryopreserved embryos (2 to 4 months) Cryopreserved embryos (within 1 month) |
Additional Info. | Necessary documents for ordering:
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BRC mice in Publications |
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No Data |