Strain Data Sheet

RBRC01235

Strain Information

Image
BRC No.RBRC01235
TypeTargeted MutationCartagena
SpeciesMus musculus
Strain nameSTOCK Ptpro<tm1Shs>/Rbrc
Former Common nameGlepp1-KO, Glepp1 Knockout mice
H-2 Haplotype
ES Cell line
Background strain
Appearanceblack (a/a B/B C/C)
Strain development開発年：2000年開発者：留守卓也先生、白澤卓二先生機関名　東京都老人総合研究所(B6 x 129) x Swiss Black, 10世代以上
Strain description受容体型チロシンホスファターゼ Glepp1 (別名 PTP-BK)を欠損したマウス
Colony maintenance(B6 x 129) x Swiss Black のランダム交配繁殖効率: A
References

Health Report

Examination Date / Room / Rack

Gene

Gene info
Gene symbolGene nameChr.Allele symbolAllele nameCommon namesPromoter
Ptproprotein tyrosine phosphatase, receptor type, O6Ptpro<tm1Shs>targeted mutation 1, Takuji ShirasawaGlepp1

Gene symbolGene nameChr.Allele symbolAllele nameCommon namesPromoter
loxPphage P1 loxP6loxP

Gene symbolGene nameChr.Allele symbolAllele nameCommon namesPromoter
loxPphage P1 loxP6loxP

Gene symbolGene nameChr.Allele symbolAllele nameCommon namesPromoter
neoneomycin resistance gene (E. coli)6neo; neomycin;mouse phosphoglycerate kinase promoter (PGK promoter)

Ordering Information

供与核酸phage P1 loxP sites, mouse phosphoglycerate kinase promoter (PGK promoter), E. coli neo, mouse Glepp1 genomic DNA[update Oct., 20, 2014]
Research applicationCell Biology Research
Cre/loxP system
提供条件条件を付加する。利用者は事前に寄託者の提供承諾書を得る。
論文発表する際、白澤　卓二を共著者に加える。
Depositor白澤　卓二（(財)東京都高齢者研究福祉振興財団）
Strain Status凍結胚のアイコン凍結胚
Strain Availability凍結胚より作出したマウスを2~4ヶ月以内に提供可能
Additional Info.Necessary documents for ordering:
  1. Approval form (Japanese / English)
  2. Order form (Japanese / English)
  3. Category I MTA: MTA for distribution with RIKEN BRC (Japanese / English)
  4. Acceptance of responsibility for living modified organism (Japanese / English)
Lab HP (Japanese), Lab HP (English)
Genotyping protocol -PCR-

BRC mice in Publications

Shintani T, Suzuki R, Takeuchi Y, Shirasawa T, Noda M.
Deletion or inhibition of PTPRO prevents ectopic fat accumulation and induces healthy obesity with markedly reduced systemic inflammation.
Life Sci 313 121292(2023) 36535401

Yu, Yang.
Regulation of retinal axonal projections by the R3 receptor-like protein tyrosine phosphatase subfamily in mice.
SOKENDAI (The Graduate University for Advanced Studies) (2018)