Strain Data Sheet

RBRC01229

Strain Information

Image
BRC No.RBRC01229
TypeTargeted Mutation and Chromosomal Aberration and F2 HybridCartagena
SpeciesMus musculus
Strain nameB6;129-Foxh1<tm1.1Hmd>/HmdRbrc
Former Common nameB6;129-FoxH1+/-, FAST+/-, B6;129-FoxH1tm1Hh(B6;129-FoxH1+/-,FAST+/- ) knockout mice
H-2 Haplotype
ES Cell lineR1 [(129X1/SvJ x 129S1/Sv)F1-Kitl<+>]
Background strain
Appearanceblack [a/a B/B C/C]
Strain development2000年、山本正道先生・坂井靖夫先生・濱田博司先生、大阪大学大学院生命機能研究科が開発ES細胞（R1）より樹立。C57BL/6Jと交配。現在B6;129でB6 側に2世代目同士の交配。
Strain descriptionFoxH1 の機能解析のための開発。
Colony maintenance繁殖効率：A（良好）形態の異常・奇形があるホモで不妊／死亡
References
The transcription factor FoxH1 (FAST) mediates Nodal signaling during anterior-posterior patterning and node formation in the mouse.
Yamamoto M, Meno C, Sakai Y, Shiratori H, Mochida K, Ikawa Y, Saijoh Y, Hamada H
Genes Dev., 15, 1242-1256 (2001). 11358868

Health Report

Examination Date / Room / Rack

Gene

Gene SymbolGene NameChr.Allele SymbolAllele NameCommon NamesPromoterDiseases Related to This Gene
FoxH1forkhead box H115FoxH1targeted mutation 1.1, Hiroshi Hamada
loxPphage P1 loxP15loxP

Phenotype

Annotation by Mammalian phenotyhpe ontology
  • abnormal azygos vein morphology(MP:0011569)

  • abnormal heart position or orientation(MP:0006065)

  • abnormal hepatic portal vein morphology(MP:0010668)

  • abnormal renal vein morphology(MP:0011323)

  • atrial septal defect(MP:0010403)
    • more 13 phenotypes
  • atrial situs inversus(MP:0010431)

  • complete atrioventricular septal defect(MP:0010413)

  • dextrocardia(MP:0000644)

  • double outlet right ventricle(MP:0000284)

  • mesocardia(MP:0000650)

  • postnatal lethality, complete penetrance(MP:0011085)

  • right atrial isomerism(MP:0006061)

  • right pulmonary isomerism(MP:0000531)

  • right-sided isomerism(MP:0000508)

  • right-sided stomach(MP:0010808)

  • spleen hypoplasia(MP:0000694)

  • transposition of great arteries(MP:0004110)

  • ventricular septal defect(MP:0010402)
    • Detailed phenotype data

    Ordering Information

    供与核酸phage P1 loxP, mouse FoxH1 genomic DNA
    Research applicationCre/loxP system
    Developmental Biology Research
    提供条件条件を付加する。
    研究成果の公表にあたって譲渡者の指定する文献を引用する。Genes Dev., 15, 1242-1256 (2001).
    Depositor濱田　博司（国立研究開発法人理化学研究所）
    Strain Status凍結胚のアイコン凍結胚
    凍結精子のアイコン凍結精子
    Strain Availability凍結胚より作出したマウスを2~4ヶ月以内に提供可能
    凍結精子を1ヶ月以内に提供可能
    凍結胚を1ヶ月以内に提供可能
    Additional Info.Necessary documents for ordering:
    1. Order form (Japanese / English)
    2. Category I MTA: MTA for distribution with RIKEN BRC (Japanese / English)
    3. Acceptance of responsibility for living modified organism (Japanese / English)

    Genotyping protocol -PCR-

    BRC mice in Publications

    No Data