Strain Data Sheet

RBRC01222

Strain Information

Image
BRC No.RBRC01222
TypeSpontaneous Mutation Congenic
SpeciesMus musculus molossinus
Strain nameMSM.HR1-Hr<hr>/Rbrc
Former Common nameMSM.Cg-Hr hr
H-2 Haplotype
ES Cell line
Background strainMSM/MsRbrc [Mus musculus molossinus]
Appearancewhite-bellied agouti without hair [A<w>/A<w> B/B C/C hr/hr]
white-bellied agouti [A<w>/A<w> B/B C/C hr/+]
Strain developmentFour congenic strains of the Hr gene have been generated using Hos:HR-1 mice as the donor strain by successive backcrossing to C57BL/6JJcl (RBRC01223), BALB/cAnNMs (RBRC01417), C3H/HeNCrlj (RBRC01418) and MSM/MsRbrc (RBRC01222) strains as recipients at Experimental Animal Division, RIKEN BioResource Center (BRC). The deposition of the four congenic strains to RIKEN BRC has been acknowledged by HOSHINO LABORATORY ANIMALS, CORP. (Masayuki Hoshino, President).
Strain description
Colony maintenanceHomozygote x Wild-type [MSM/Ms] (Corss-Intercross Breeding)
References

Health Report

Examination Date / Room / Rack

Gene

Gene SymbolGene NameChr.Allele SymbolAllele NameCommon NamesPromoterDiseases Related to This Gene
Hrlysine demethylase and nuclear receptor corepressor14Hr
hairless
  • alopecia universalis congenita(DisGeNET, MedGEN)

  • atrichia with papular lesions(DisGeNET, MedGEN)

    • Phenotype

    Annotation by Mammalian phenotyhpe ontology
  • abnormal dermis reticular layer morphology(MP:0005081)

  • abnormal mammary gland morphology(MP:0000627)

  • abnormal nursing(MP:0001382)

  • abnormal skin morphology(MP:0002060)

  • absent linear vestibular evoked potential(MP:0004813)
    • more 10 phenotypes
  • decreased T cell number(MP:0005018)

  • decreased T cell proliferation(MP:0005095)

  • deformed nails(MP:0000580)

  • dermal cyst(MP:0001247)

  • epidermal hyperplasia(MP:0001222)

  • hairless(MP:0003815)

  • hyperkeratosis(MP:0001242)

  • increased leukemia incidence(MP:0002026)

  • increased macrophage cell number(MP:0005425)

  • sebaceous gland atrophy(MP:0000649)
    • Detailed phenotype data

    Ordering Information

    Donor DNA
    Research applicationCancer Research
    Cell Biology Research
    Dermatology Research
    Genetics Research
    Metabolism Research
    Mouse Models for Human Disease
    Toxicology Research
    Specific Term and Conditions1) The BIOLOGICAL RESOURCE shall be used only for academic research purposes by a not-for-profit organization.
    2) The RECIPIENT must negotiate with RIKEN BRC and HOSHINO LABORATORY ANIMALS, CORP. and acquire a prior written consent to filing an application for a patent, or intellectual property or other rights based on the research results using the BIOLOGICAL RESOURCE.
    3) The RECIPIENT of a for-profit organization must negotiate with HOSHINO LABORATORY ANIMALS, CORP. and obtain a prior written approval to use the BIOLOGICAL RESOURCE.
    4) The RECIPIENT agrees that RIKEN BRC informs biannually to HOSHINO LABORATORY ANIMALS, CORP. of RECIPIENT organization name and quantity of distributed animals.
    DepositorAtsushi Yoshiki (RIKEN)
    Strain Statusan icon for Frozen spermFrozen sperm
    Strain AvailabilityRecovery and QC required prior to distribution
    Additional Info.Necessary documents for ordering:
    1. Order form (Japanese / English)
    2. Category I MTA: MTA for distribution with RIKEN BRC (Japanese / English)
    Hos:HR-1 (Japanese)
    Genotyping protocol -PCR-
    Mouse of the Month Nov 2011

    BRC mice in Publications

    No Data