Strain Data Sheet

RBRC01220

update : 2025-03-19

Strain Information
Image
BRC No.	RBRC01220
Type	Inbred
Species	Mus musculus
Strain name	A/J
Former Common name
H-2 Haplotype
ES Cell line
Background strain	A
Appearance	albino [a/a b/b c/c]
Strain development	Developed by Dr. L.C. Strong in 1921. The A/J strain was produced by crossing between the Cold Spring Harbor and Bagg albino random-bred stock. Deposited by Dr. Masahiko Nishimura at Hamamatsu University School of Medicine.
Strain description	Albino (a/a b/b c/c). Developed by Dr. L.C. Strong, 1921. Parental strain of SMXA RI strains.
Colony maintenance	Sibling x Sibling
References	Genetic analysis of mortality in murine angiostrongyliasis costaricensis using SMXA recombinant inbred mouse strains. Ishih A, Ohno T, Nishimura M, Terada M Parasitol Int, 49(4):335-338 (2000). 11077268 Characterization of hyperinsulinemic recombinant inbred (RI) strains (SMXA-5 and SMXA-9) derived from normoinsulinemic SM/J and A/J mice. Anunciado R V, Horio F, Ohno T, Tanaka S, Nishimura M, Namikawa T Exp Anim, 49(2):83-90 (2000). 10889946 Distribution of body weight, blood insulin and lipid levels in the SMXA recombinant inbred strains and the QTL analysis. Anunciado R V, Ohno T, Mori M, Ishikawa A, Tanaka S, Horio F, Nishimura M, Namikawa T Exp Anim, 49(3):217-224 (2000). 11109545 Quantitative trait loci for body weight in the intercross between SM/J and A/J mice. Anunciado R V, Nishimura M, Mori M, Ishikawa A, Tanaka S, Horio F, Ohno T, Namikawa T Exp Anim, 50(4):319-324 (2001). 11515095 Chromosomal mapping of host susceptibility loci to Angiostrongylus costaricensis nematode infection in mice. Ohno T, Ishih A, Tanaka S, Nishimura M, Terada M Immunogenetics, 53(10-11):925-929 (2002). 11862393 Combinations of nondiabetic parental genomes elicit impaired glucose tolerance in mouse SMXA recombinant inbred strains. Kobayashi M, Ohno T, Tsuji A, Nishimura M, Horio F Diabetes, 52(1):180-186 (2003). 12502510 Quantitative trait locus analysis of serum insulin, triglyceride, total cholesterol and phospholipid levels in the (SM/J x A/J)F2 mice. Anunciado R V, Nishimura M, Mori M, Ishikawa A, Tanaka S, Horio F, Ohno T, Namikawa T Exp Anim, 52(5):415-417 (2003). 12638235 Quantitative trait locus analysis of serum insulin, triglyceride, total cholesterol and phospholipid levels in the (SM/J x A/J)F2 mice. Anunciado R V, Nishimura M, Mori M, Ishikawa A, Tanaka S, Horio F, Ohno T, Namikawa T Exp Anim, 52(1):37-42 (2003). 12638235 SMXA-5 mouse as a diabetic model susceptible to feeding a high-fat diet. Kobayashi M, Io F, Kawai T, Nishimura M, Ohno T, Horio F Biosci Biotechnol Biochem, 68(1):226-230 (2004). 14745189 Major quantitative trait locus on chromosome 2 for glucose tolerance in diabetic SMXA-5 mouse established from non-diabetic SM/J and A/J strains. Kobayashi M, Io F, Kawai T, Kumazawa M, Ikegami H, Nishimura M, Ohno T, Horio F Diabetologia, 49(3):486-495 (2006). 16447060 more 8 references Serum adiponectin concentration: its correlation with diabetes-related traits and quantitative trait loci analysis in mouse SMXA recombinant inbred strains. Kobayashi M, Ohno T, Kawada T, Ikegami H, Nishimura M, Horio F Biosci Biotechnol Biochem, 70(3): 677-683 (2006). 16556985 Searching for genetic factors of fatty liver in SMXA-5 mice by quantitative trait loci analysis under a high-fat diet. Kumazawa M, Kobayashi M, Io F, Kawai T, Nishimura M, Ohno T, Horio F J Lipid Res, 48(9): 2039-2046 (2007). 17595448 Quantitative trait loci for impaired glucose tolerance in nondiabetic SM/J and A/J mice. Hada N, Kobayashi M, Fujiyoshi M, Ishikawa A, Kuga M, Nishimura M, Ebihara S, Ohno T, Horio F Physiol Genomics, 35(1): 65-74 (2008). 18628340 Confirmation of diabetes-related quantitative trait loci derived from SM/J and A/J mice by using congenic strains fed a high-carbohydrate or high-fat diet. Kobayashi M, Hada N, Hoshino H, Ozawa T, Umeshita K, Nishimura M, Murai A, Ohno T, Horio F J Nutr Sci Vitaminol, 55(3): 257-263 (2009). 19602834 Body and major organ weights of A/J-Chr 11(SM) consomic mice. Tanaka S, Mizorogi T, Nishijima K, Kuwahara S, Tsujio M, Aoyama H, Taguchi C, Kobayashi M, Horio F, Ohno T Exp Anim, 58(4): 357-361 (2009). 19654433 Genetic analysis of abdominal fat distribution in SM/J and A/J mice. Kobayashi M, Ohno T, Hada N, Fujiyoshi M, Kuga M, Nishimura M, Murai A, Horio F J Lipid Res, 51(12): 3463-3469 (2010). 20802160 Establishment of consomic strains derived from A/J and SM/J mice for genetic analysis of complex traits. Ohno T, Hata K, Baba T, Io F, Kobayashi M, Horio F, Nishimura M Mamm Genome, 23(11-12):764-769 (2012). 23052825 Detection of loci for allergic asthma using SMXA recombinant inbred strains of mice. Ohno T, Okamoto M, Hara T, Hashimoto N, Imaizumi K, Matsushima M, Nishimura M, Shimokata K, Hasegawa Y, Kawabe T Immunogenetics, 65(1):17-24 (2013). 23081743

Health Report
Examination Date / Room / Rack

Gene
Gene Symbol	Gene Name	Chr.	Allele Symbol	Allele Name	Common Names	Promoter	Diseases Related to This Gene

Phenotype
Annotation by Mammalian phenotyhpe ontology	obsolete no phenotypic analysis(MP:0003012)
Detailed phenotype data

Ordering Information
Donor DNA
Research application	Genetics Research
Specific Term and Conditions	No specific terms and conditions. (The DEPOSITOR waives its own rights under any patents, intellectual property, or other proprietary rights with respect to the results to be obtained by use of the BIOLOGICAL RESOURCE.)
Depositor	Masahiko Nishimura (Nagoya University)
Strain Status	Frozen embryos
Strain Availability	Recovered litters from cryopreserved embryos (2 to 4 months)
Additional Info.	Necessary documents for ordering: Order form (Japanese / English) Category I MTA: MTA for distribution with RIKEN BRC (Japanese / English)

BRC mice in Publications

No Data