Strain Information | |
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Image | |
BRC No. | RBRC01200 |
Type | Transgene Congenic |
Species | Mus musculus |
Strain name | NZW.C3-Tg(Mt1-Il5)6Ato |
Former Common name | NZW.IL-5 |
H-2 Haplotype | |
ES Cell line | |
Background strain | NZW |
Appearance | albino [b/b c/c p/p] |
Strain development | Generated by Kiyoshi Takatsu, Kumamoto University Medical School. The transgene was injected into the pronuclei of C3H fertilized eggs. C57BL/6 (RBRC01908) and BALB/c (RBRC05910) background (Developed by Institute of Medical Science, University of Tokyo), NZW background (RBRC01200) (Developed by Juntendo University School of Medicine). |
Strain description | Mt1-Il5 transgenic mice. These transgenic mice express mouse IL-5 under the control of the Mt1 promoter. |
Colony maintenance | Carrier x Noncarrier [or Crossing to NZW/NSlc] Tg mice show no obvious abnormality. |
References | Transgenic mice expressing a B cell growth and differentiation factor gene (interleukin 5) develop eosinophilia and autoantibody production. Tominaga A, Takaki S, Koyama N, Katoh S, Matsumoto R, Migita M, Hitoshi Y, Hosoya Y, Yamauchi S, Kanai Y, et a l J. Exp. Med., 173, 429-437 (1991). 1988543Transgene-mediated hyper-expression of IL-5 inhibits autoimmune disease but increases the risk of B cell chronic lymphocytic leukemia in a model of murine lupus. Wen X, Zhang D, Kikuchi Y, Jiang Y, Nakamura K, Xiu Y, Tsurui H, Takahashi K, Abe M, Ohtsuji M, Nishimura H, Takatsu K, Shirai T, Hirose S Eur. J. immunol., 34, 2740-2749 (2004). 15368290 |
Health Report | |
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Examination Date / Room / Rack |
Gene | |||||||
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Gene Symbol | Gene Name | Chr. | Allele Symbol | Allele Name | Common Names | Promoter | Diseases Related to This Gene |
HBB2 | rabbit beta-globin splice donor | UN | HBB2 | ||||
HBB2 | rabbit beta-globin splice acceptor | UN | HBB2 | ||||
Il5 | interleukin 5 | UN | Il5 | mouse metallothionein promoter, rabbit beta-globin |
Phenotype | |
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Annotation by Mammalian phenotyhpe ontology | more 3 phenotypes |
Detailed phenotype data |
Ordering Information | |
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Donor DNA | mouse metallothionein promoter, rabbit beta-globin SD, rabbit beta-globin SA, mouse IL5 cDNA, rabbit beta-globin polyA, SV40 polyadenylation site |
Research application | Immunology and Inflammation Research |
Specific Term and Conditions | In publishing the research results obtained by use of the BIOLOGICAL RESOURCE, a citation of the following literature(s) designated by the DEPOSITOR is requested. Eur. J. Immunol., 34, 2740-2749 (2004). |
Depositor | Sachiko Hirose (Juntendo University) |
Strain Status | Frozen embryos |
Strain Availability | Recovered litters from cryopreserved embryos (2 to 4 months) Cryopreserved embryos (within 1 month) |
Additional Info. | Necessary documents for ordering:
Genotyping protocol -PCR- |
BRC mice in Publications |
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No Data |