Strain Data Sheet

RBRC01195

Strain Information

Image
BRC No.RBRC01195
TypeTargeted Mutation CongenicCartagena
SpeciesMus musculus
Strain nameB6.129S6-Grin2a<tm1Nak>/NakRbrc
Former Common nameNR2A KO, C57BL/6J-Grin2a tm
H-2 Haplotype
ES Cell lineCCE/EK.CCE [129S/SvEv-Gpi1<c>]
Background strainC57BL/6JJcl
Appearanceblack [a/a B/B C/C)]
Strain developmentC57BL/6Jに13世代バッククロスしている
Strain descriptionB6.129S6-Grin2a<tm1Nak>. The Grin2a gene is one of the glutamate receptor channel subunit families forming NMDA receptor channel, which is important for synaptic plasticity. Homozygous mutant mice are viable and fertile.
Colony maintenance特記事項なし繁殖効率：A
ReferencesJ. Neurosci., 16, 7859-7867 (1996). 8987814

Health Report

Examination Date / Room / Rack

Gene

Gene info
Gene symbolGene nameChr.Allele symbolAllele nameCommon namesPromoter
Grin2aglutamate receptor, ionotropic, NMDA2A (epsilon 1)16Grin2a<tm1Nak>targeted mutation 1, Shigetada Nakanishi

Gene symbolGene nameChr.Allele symbolAllele nameCommon namesPromoter
neoneomycin resistance gene (E. coli)16neo; neomycin;herpes simplex virus thymidine kinase promoter (HSV tk promoter)

Ordering Information

供与核酸herpes simplex virus thymidine kinase promoter (HSV tk promoter), E. coli neo, mouse NMDA receptor NR2A subunit genomic DNA
Research applicationNeurobiology Research
提供条件条件を付加する。
研究成果の公表にあたって寄託者の指定する文献を引用する。J. Neurosci., 16, 7859-7867 (1996).
研究成果の公表にあたって謝辞の表明を必要とする。
Depositor中西　重忠（国立大学法人京都大学）
Strain Status凍結胚のアイコン凍結胚
凍結精子のアイコン凍結精子
Strain Availability凍結胚より作出したマウスを2~4ヶ月以内に提供可能
凍結精子を1ヶ月以内に提供可能
凍結胚を1ヶ月以内に提供可能
Additional Info.Necessary documents for ordering:
  1. Order form (Japanese / English)
  2. Category I MTA: MTA for distribution with RIKEN BRC (Japanese / English)
  3. Acceptance of responsibility for living modified organism (Japanese / English)

Genotyping protocol -PCR-

BRC mice in Publications

Lu Y, Mu L, Elstrott J, Fu C, Sun C, Su T, Ma X, Yan J, Jiang H, Hanson JE, Geng Y, Chen Y.
Differential depletion of GluN2A induces heterogeneous schizophrenia-related phenotypes in mice.
EBioMedicine 102 105045(2024) 38471394

Gao X, Qiao Y, Jia B, Jing X, Cheng B, Wen L, Tan Q, Zhou Y, Zhu B, Qiao H.
NMDA Receptor-Dependent Synaptic Activity in Dorsal Motor Nucleus of Vagus Mediates the Enhancement of Gastric Motility by Stimulating ST36.
Evid Based Complement Alternat Med 2012 438460(2012) 23118791

Su T, Lu Y, Fu C, Geng Y, Chen Y.
GluN2A mediates ketamine-induced rapid antidepressant-like responses.
Nat Neurosci (2023) 37709995