Strain Data Sheet

RBRC01194

Strain Information

Image
BRC No.RBRC01194
TypeTransgene CongenicCartagena
SpeciesMus musculus
Strain nameB6.Cg-Tg(Grm2-IL2RA/EGFP)IG8Nak/NakRbrc
Former Common nameC57BL/6J-TgN(grm2-IL2RA/GFP)1kyo/IG8
H-2 Haplotype
ES Cell line
Background strainC57BL/6J
Appearance
Strain developmentDeveloped by Drs. Dai Watanabe and Shigetada Nakanishi, Kyoto University Faculty of Medicine in 1998.
Strain descriptionThis transgenic mouse strain expresses EGFP and human IL2RA genes under the control of the mGluR promoter.
Colony maintenance
References
Ablation of cerebellar Golgi cells disrupts synaptic integration involving GABA inhibition and NMDA receptor activation in motor coordination.
D Watanabe, H Inokawa, K Hashimoto, N Suzuki, M Kano, R Shigemoto, T Hirano, K Toyama, S Kaneko, M Yokoi, K Moriyoshi, M Suzuki, K Kobayashi, T Nagatsu, R J Kreitman, I Pastan, S Nakanishi
Cell, 95, 17-27 (1998). 9778244

A key role of starburst amacrine cells in originating retinal directional selectivity and optokinetic eye movement.
K Yoshida, D Watanabe, H Ishikane, M Tachibana, I Pastan, S Nakanishi
Neuron, 30, 771-780 (2001). 11430810

Health Report

Examination Date / Room / Rack

Gene

Gene SymbolGene NameChr.Allele SymbolAllele NameCommon NamesPromoterDiseases Related to This Gene
GFP Green Fluorescent Protein (Aequorea victoria)UN
IL2RA Interleukin-2 receptor α-subunit (human)UNIL2RA mouse metabotropic glutamate receptor 2 promoter

Phenotype

Phenotype annotation from literatures by Mammalian phenotype ontology
  • abnormal motor coordination/balance (MP:0001516)

  • athetotic walking movements (MP:0001527)
    • Detailed phenotype data

    Ordering Information

    Donor DNAmouse metabotropic glutamate receptor 2 (GluR2) genomic DNA, human IL-2R alpha cDNA, SV40 poly A signals, Jellyfish GFP cDNA
    Research applicationCell Biology Research
    Fluorescent Proteins/lacZ System
    Neurobiology Research
    Specific Term and ConditionsIn publishing the research results obtained by use of the BIOLOGICAL RESOURCE, a citation of the following literature(s) designated by the DEPOSITOR is requested. Cell, 95, 17-27 (1998). Neuron, 30, 771-780 (2001).In publishing the research results to be obtained by use of the BIOLOGICAL RESOURCE, an acknowledgment to the DEPOSITOR is requested.
    DepositorShigetada Nakanishi (Kyoto University)
    Strain Statusan icon for Frozen embryosFrozen embryos
    an icon for Frozen spermFrozen sperm
    Strain AvailabilityRecovered litters from cryopreserved embryos (2 to 4 months)
    Cryopreserved sperm (within 1 month)
    Additional Info.Necessary documents for ordering:
    1. Order form (Japanese / English)
    2. Category I MTA: MTA for distribution with RIKEN BRC (Japanese / English)
    3. Acceptance of responsibility for living modified organism (Japanese / English)

    Genotyping protocol -PCR-

    BRC mice in Publications

    No Data