Strain Data Sheet
RBRC01171
Strain Information | |
|---|---|
| Image | |
| BRC No. | RBRC01171 |
| Type | Targeted Mutation |
| Species | Mus musculus |
| Strain name | C.Cg-Hivep2<tm1Sis>/Rbrc |
| Former Common name | Schnurri-2(Shn-2) Knockout mice -BALB/c |
| H-2 Haplotype | |
| ES Cell line | |
| Background strain | BALB/cAJcl |
| Appearance | |
| Strain development | 開発年：1998年開発者：高木豪先生機関名：理研BALB/c ♀と13回 backcrossしたもの |
| Strain description | 免疫欠損に近いと思われる |
| Colony maintenance | +/- で維持可能ホモで不妊／死亡 |
| References | Nat. Immunol., 2, 1048-1053 (2001). 11668343 |
Health Report | |
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| Examination Date / Room / Rack | |
Gene | |
|---|---|
| Gene info | Gene symbolGene nameChr.Allele symbolAllele nameCommon namesPromoter Hivep2human immunodeficiency virus type I enhancer binding protein 210Hivep2<tm1Sis>targeted mutation 1, Shunsuke IshiiSchnurri-2, MIBP1, Shn-2 Gene symbolGene nameChr.Allele symbolAllele nameCommon namesPromoter neoneomycin resistance gene (E. coli)10neo; neomycin;mouse phosphoglycerate kinase promoter (PGK promoter) |
Ordering Information | |
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| 供与核酸 | mouse phosphoglycerate kinase promoter (PGK promoter), E. coli neo, mouse Schnurri-2 genomic DNA |
| Research application | Immunology and Inflammation Research |
| 提供条件 | 条件を付加する。 研究成果の公表にあたって譲渡者の指定する文献を引用する。Nat. Immunol., 2, 1048-1053 (2001). 研究成果の公表にあたって謝辞の表明を必要とする。 |
| Depositor | 石井 俊輔（独立行政法人理化学研究所） |
| Strain Status |  凍結胚 |
| Strain Availability | 凍結胚より作出したマウスを2~4ヶ月以内に提供可能 |
| Additional Info. | Necessary documents for ordering:
Genotyping protocol -PCR- |
BRC mice in Publications |
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Takao K, Kobayashi K, Hagihara H, Ohira K, Shoji H, Hattori S, Koshimizu H, Umemori J, Toyama K, Nakamura HK, Kuroiwa M, Maeda J, Atsuzawa K, Esaki K, Yamaguchi S, Furuya S, Takagi T, Walton NM, Hayashi N, Suzuki H, Higuchi M, Usuda N, Suhara T, Nishi A, Matsumoto M, Ishii S, Miyakawa T. Deficiency of schnurri-2, an MHC enhancer binding protein, induces mild chronic inflammation in the brain and confers molecular, neuronal, and behavioral phenotypes related to schizophrenia. Neuropsychopharmacology 38(8) 1409-25(2013) 23389689 |