Strain Data Sheet
RBRC01153
Strain Information | |
|---|---|
| Image | |
| BRC No. | RBRC01153 |
| Type | Transgene |
| Species | Mus musculus |
| Strain name | B6.Cg-Tg(Six3-cre)22Frty |
| Former Common name | TgN(Six3 Cre)22Frt; Six3Cre#22 |
| H-2 Haplotype | |
| ES Cell line | |
| Background strain | |
| Appearance | |
| Strain development | Developed by Yasuhide Furuta, University of Texas, M.D. Anderson Cancer Center. The Six3-cre transgene fragment was injected into the pronuclei of B6D2F2 fertilized eggs. The mice were crossed to C57BL/6 (N5 times). |
| Strain description | Transgenic mice expressing Cre recombinase in a central region of the developing retina and widely in the ventral forebrain. Useful for tissue-specific gene activation/inactivation approaches. In particular, consequences of gene activation/inactivation in Cre-expressing cells within the retina can be assessed in direct comparisons to the surrounding non-Cre-expressing cells in an animal. Line 69 (RBRC01154), Line 22 (RBRC01153). |
| Colony maintenance | Carrier x Carrier |
| References | Retina- and ventral forebrain-specific Cre recombinase activity in transgenic mice. Y Furuta, O Lagutin, B L Hogan, G C Oliver Genesis, 26, 130-132 (2000). 10686607 |
Health Report | |
|---|---|
| Examination Date / Room / Rack | |
Gene | |||||||
|---|---|---|---|---|---|---|---|
| Gene Symbol | Gene Name | Chr. | Allele Symbol | Allele Name | Common Names | Promoter | Diseases Related to This Gene |
| GH | Growth hormone polyA (Bovine) | UN | GH | ||||
| cre | Phage P1 Cre recombinase | UN | cre | mouse Six3 promoter | |||
| nls | SV40 large T antigen nuclear localization signal (NLS) | UN | nls | ||||
Phenotype | |
|---|---|
| Phenotype annotation from literatures by Mammalian phenotype ontology | |
| Detailed phenotype data | |
Ordering Information | |
|---|---|
| Donor DNA | mouse six3 genomic DNA, SV40-T-derived nuclear localization signal (NLS), phage P1 Cre recombinase, bovine Growth Hormone poly-A signal |
| Research application | Cell Biology Research Cre/loxP system Genetics Research Cre driver |
| Specific Term and Conditions | In publishing the research results obtained by use of the BIOLOGICAL RESOURCE, a citation of the following literature(s) designated by the DEPOSITOR is requested. Genesis, 26, 130-132 (2000). |
| Depositor | Yasuhide Furuta (The University of Texas M. D. Anderson Cancer Center) |
| Strain Status |  Frozen embryos |
| Strain Availability | Recovered litters from cryopreserved embryos (2 to 4 months) Cryopreserved embryos (within 1 month) |
| Additional Info. | Necessary documents for ordering:
Genotyping protocol -PCR- Mouse of the Month June 2006 |
BRC mice in Publications |
|---|
| No Data |