Strain Data Sheet
RBRC01151
Strain Information | |
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| Image | |
| BRC No. | RBRC01151 |
| Type | Targeted Mutation |
| Species | Mus musculus |
| Strain name | B6;129S7-Hey1<tm1Kkb>/YsaRbrc |
| Former Common name | hesr1, hairy and enhancer of split-related 1 |
| H-2 Haplotype | |
| ES Cell line | AB1 [129S7/SvEvBrd-Hprt<+>] |
| Background strain | C57BL/6NJcl |
| Appearance | black [a/a B/B C/C] |
| Strain development | 開発年：1999年開発者：Hiroki Kokubo, Randy L Johnson機関名：University of Texas M.D. Anderson Cancer Center |
| Strain description | neoはぬいていない。 |
| Colony maintenance | SPF化の際のB6マウスの亜系統名と購入元：クレア：B6/Nホモの致死性(繁殖性）：hesr1はviable |
| References | Dev Biol., 278, 301-309 (2005）. 15680351 |
Health Report | |
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| Examination Date / Room / Rack | |
Gene | |
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| Gene info | Gene symbolGene nameChr.Allele symbolAllele nameCommon namesPromoter Hey1hairy and enhancer of split-related 13Hey1<tm1Kkb>targeted mutation 1, Hiroki KokuboHairy/E(spl)-related with YRPW motif 1, Herp2, hesr-1, HRT1 Gene symbolGene nameChr.Allele symbolAllele nameCommon namesPromoter IRESinternal ribosomal entry site (EMCV)3internal ribosomal entry site from EMCV Gene symbolGene nameChr.Allele symbolAllele nameCommon namesPromoter lacZbeta-galactosidase (E. coli)3 Gene symbolGene nameChr.Allele symbolAllele nameCommon namesPromoter loxPphage P1 loxP3loxP Gene symbolGene nameChr.Allele symbolAllele nameCommon namesPromoter loxPphage P1 loxP3loxP Gene symbolGene nameChr.Allele symbolAllele nameCommon namesPromoter neoneomycin resistance gene (E. coli)3neo; neomycin;mouse phosphoglycerate kinase promoter (PGK promoter) |
Ordering Information | |
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| 供与核酸 | Encephalomyocarditis virus (EMCV) internal ribosomal entry site (ires), E. coli lacZ, phage P1 loxP sites, mouse phosphoglycerate kinase promoter (PGK promoter), E. coli neo, mouse hairy and enhancer of split-related 1 genomic DNA |
| Research application | Cell Biology Research Cre/loxP system |
| 提供条件 | 条件を付加する。 研究成果の公表にあたって謝辞の表明を必要とする。 |
| Depositor | 相賀 裕美子（国立遺伝学研究所） |
| Strain Status |  凍結胚 凍結精子 |
| Strain Availability | 凍結胚より作出したマウスを2~4ヶ月以内に提供可能 凍結精子を1ヶ月以内に提供可能 凍結胚を1ヶ月以内に提供可能 |
| Additional Info. | Necessary documents for ordering:
Genotyping protocol -PCR- |
BRC mice in Publications |
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Harada Y, Yamada M, Imayoshi I, Kageyama R, Suzuki Y, Kuniya T, Furutachi S, Kawaguchi D, Gotoh Y. Cell cycle arrest determines adult neural stem cell ontogeny by an embryonic Notch-nonoscillatory Hey1 module. Nat Commun 12(1) 6562(2021) 34772946 |