Strain Data Sheet

RBRC01151

Strain Information

Image
BRC No.RBRC01151
TypeTargeted MutationCartagena
SpeciesMus musculus
Strain nameB6;129S7-Hey1<tm1Kkb>/YsaRbrc
Former Common namehesr1, hairy and enhancer of split-related 1
H-2 Haplotype
ES Cell lineAB1 [129S7/SvEvBrd-Hprt<+>]
Background strainC57BL/6NJcl
Appearanceblack [a/a B/B C/C]
Strain development開発年：1999年開発者：Hiroki Kokubo, Randy L Johnson機関名：University of Texas M.D. Anderson Cancer Center
Strain descriptionneoはぬいていない。
Colony maintenanceSPF化の際のB6マウスの亜系統名と購入元：クレア：B6/Nホモの致死性(繁殖性）：hesr1はviable
References
Mouse hesr1 and hesr2 genes are redundantly required to mediate Notch signaling in the developing cardiovascular system.
Kokubo H, Miyagawa-Tomita S, Nakazawa M, Saga Y, Johnson R L
Dev Biol., 278,　301-309 (2005）. 15680351

Health Report

Examination Date / Room / Rack

Gene

Gene SymbolGene NameChr.Allele SymbolAllele NameCommon NamesPromoterDiseases Related to This Gene
Hey1hairy/enhancer-of-split related with YRPW motif 13Hey1targeted mutation 1, Hiroki Kokubo
IRESinternal ribosomal entry site (EMCV)3
lacZbeta-galactosidase (E. coli)3
loxPphage P1 loxP3loxP
loxPphage P1 loxP3loxP
neoneomycin resistance gene (E. coli)3mouse phosphoglycerate kinase promoter (PGK promoter)

Phenotype

Annotation by Mammalian phenotyhpe ontology
  • muscle phenotype(MP:0005369)

  • no abnormal phenotype detected(MP:0002169)
    • Detailed phenotype data

    Ordering Information

    供与核酸Encephalomyocarditis virus (EMCV) internal ribosomal entry site (ires), E. coli lacZ, phage P1 loxP sites, mouse phosphoglycerate kinase promoter (PGK promoter), E. coli neo, mouse hairy and enhancer of split-related 1 genomic DNA
    Research applicationCell Biology Research
    Cre/loxP system
    提供条件条件を付加する。
    研究成果の公表にあたって謝辞の表明を必要とする。
    Depositor相賀　裕美子（国立遺伝学研究所）
    Strain Status凍結胚のアイコン凍結胚
    凍結精子のアイコン凍結精子
    Strain Availability凍結胚より作出したマウスを2~4ヶ月以内に提供可能
    凍結精子を1ヶ月以内に提供可能
    凍結胚を1ヶ月以内に提供可能
    Additional Info.Necessary documents for ordering:
    1. Order form (Japanese / English)
    2. Category I MTA: MTA for distribution with RIKEN BRC (Japanese / English)
    3. Acceptance of responsibility for living modified organism (Japanese / English)
    Saga Lab HP
    Genotyping protocol -PCR-

    BRC mice in Publications

    Harada Y, Yamada M, Imayoshi I, Kageyama R, Suzuki Y, Kuniya T, Furutachi S, Kawaguchi D, Gotoh Y.
    Cell cycle arrest determines adult neural stem cell ontogeny by an embryonic Notch-nonoscillatory Hey1 module.
    Nat Commun 12(1) 6562(2021) 34772946