Strain Information | |
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Image | |
BRC No. | RBRC01145 |
Type | Targeted Mutation |
Species | Mus musculus |
Strain name | ICR.Cg-Mesp1<tm2(cre)Ysa>/YsaRbrc |
Former Common name | Mesp1-cre |
H-2 Haplotype | |
ES Cell line | TT2 [(C57BL/6NCrlj x CBA/JNCrlj)F1] |
Background strain | ICR MCH |
Appearance | Agouti or black [A/? or a/a B/B Mesp1-Cre c/+ C] albino [A/? or a/a B/B + c/+ C] |
Strain development | 開発年:1998年開発者:相賀裕美子先生機関名:国立医薬品食品衛生研究所 |
Strain description | Mesp1 遺伝子座 cre recombinase が発現。 |
Colony maintenance | 第7番染色体にのっており、tyrosinase gene と近いので、アルビノと交配すると、targeted allele を持つものは、茶か黒になる (ほとんどアグーチ)。交配に供したICRの購入元:クレア(MCH) |
References | Development, 126, 3437-3447 (1999). 10393122 |
Health Report | |
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Examination Date / Room / Rack |
Gene | |
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Gene info | Gene symbolGene nameChr.Allele symbolAllele nameCommon namesPromoter Gene symbolGene nameChr.Allele symbolAllele nameCommon namesPromoter crePhage P1 Cre recombinase7creMesp1 Gene symbolGene nameChr.Allele symbolAllele nameCommon namesPromoter neoneomycin resistance gene (E. coli)7neo; neomycin;mouse phosphoglycerate kinase promoter (PGK promoter) |
Ordering Information | |
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供与核酸 | phage P1 Cre recombinase, mouse phosphoglycerate kinase promoter (PGK promoter), E. coli neo, mouse Mesp1 genomic DNA |
Research application | Cre/loxP system Developmental Biology Research |
提供条件 | 条件を付加する。 研究成果の公表にあたって寄託者の指定する文献を引用する。Development, 126, 3437-3447 (1999). |
Depositor | 相賀 裕美子(国立遺伝学研究所) |
Strain Status | 凍結胚 凍結精子 |
Strain Availability | 凍結胚より作出したマウスを2~4ヶ月以内に提供可能 凍結精子を1ヶ月以内に提供可能 凍結胚を1ヶ月以内に提供可能 |
Additional Info. | Necessary documents for ordering:
Genotyping protocol -PCR- Mouse of the Month Feb 2006 Genetic Background |
BRC mice in Publications |
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Funato N, Heliövaara A, Boeckx C. A regulatory variant impacting TBX1 expression contributes to basicranial morphology in Homo sapiens. Am J Hum Genet (2024) 38608674 MacDonald ST, Bamforth SD, Chen CM, Farthing CR, Franklyn A, Broadbent C, Schneider JE, Saga Y, Lewandoski M, Bhattacharya S. Epiblastic Cited2 deficiency results in cardiac phenotypic heterogeneity and provides a mechanism for haploinsufficiency. Cardiovasc Res 79(3) 448-57(2008) 18440989 Lindsley RC, Gill JG, Murphy TL, Langer EM, Cai M, Mashayekhi M, Wang W, Niwa N, Nerbonne JM, Kyba M, Murphy KM. Mesp1 coordinately regulates cardiovascular fate restriction and epithelial-mesenchymal transition in differentiating ESCs. Cell Stem Cell 3(1) 55-68(2008) 18593559 Thompson H, Ohazama A, Sharpe PT, Tucker AS. The origin of the stapes and relationship to the otic capsule and oval window. Dev Dyn 241(9) 1396-404(2012) 22778034 Rothova M, Thompson H, Lickert H, Tucker AS. Lineage tracing of the endoderm during oral development. Dev Dyn 241(7) 1183-91(2012) 22581563 Funato N, Nakamura M, Richardson JA, Srivastava D, Yanagisawa H. Loss of Tbx1 induces bone phenotypes similar to cleidocranial dysplasia. Hum Mol Genet 24(2) 424-35(2015) 25209980 Randall V, McCue K, Roberts C, Kyriakopoulou V, Beddow S, Barrett AN, Vitelli F, Prescott K, Shaw-Smith C, Devriendt K, Bosman E, Steffes G, Steel KP, Simrick S, Basson MA, Illingworth E, Scambler PJ. Great vessel development requires biallelic expression of Chd7 and Tbx1 in pharyngeal ectoderm in mice. J Clin Invest 119(11) 3301-10(2009) 19855134 Funato N, Srivastava D, Shibata S, Yanagisawa H. TBX1 Regulates Chondrocyte Maturation in the Spheno-occipital Synchondrosis. J Dent Res 99(10) 1182-1191(2020) 32442036 Domínguez-Frutos E, Vendrell V, Alvarez Y, Zelarayan LC, López-Hernández I, Ros M, Schimmang T. Tissue-specific requirements for FGF8 during early inner ear development. Mech Dev 126(10) 873-81(2009) 19619645 |