BRC No.RBRC01145
TypeTargeted MutationCartagena
SpeciesMus musculus
Strain nameICR.Cg-Mesp1<tm2(cre)Ysa>/YsaRbrc
Former Common nameMesp1-cre
H-2 Haplotype
ES Cell lineTT2 [(C57BL/6NCrlj x CBA/JNCrlj)F1]
Background strainICR MCH
AppearanceAgouti or black [A/? or a/a B/B Mesp1-Cre c/+ C]
albino [A/? or a/a B/B + c/+ C]
Strain development開発年:1998年開発者:相賀裕美子先生機関名:国立医薬品食品衛生研究所
Strain descriptionMesp1 遺伝子座 cre recombinase が発現。
Colony maintenance第7番染色体にのっており、tyrosinase gene と近いので、アルビノと交配すると、targeted allele を持つものは、茶か黒になる (ほとんどアグーチ)。交配に供したICRの購入元:クレア(MCH)
ReferencesDevelopment, 126, 3437-3447 (1999). 10393122

Health Report

Examination Date / Room / Rack2012/04/16Room:3-DRack:A


Gene info
Gene symbolGene nameChr.Allele symbolAllele namePromoter
Mesp1mesoderm posterior 17Mesp1<tm2(cre)Ysa>targeted mutation 2 (cre), Yumiko Saga

Gene symbolGene nameChr.Allele symbolAllele namePromoter
crePhage P1 Cre recombinase7creMesp1

Gene symbolGene nameChr.Allele symbolAllele namePromoter
neoneomycin resistance gene (E. coli)7mouse phosphoglycerate kinase promoter (PGK promoter)


供与核酸phage P1 Cre recombinase, mouse phosphoglycerate kinase promoter (PGK promoter), E. coli neo, mouse Mesp1 genomic DNA
Research applicationCre/loxP system
Developmental Biology Research
研究成果の公表にあたって寄託者の指定する文献を引用する。Development, 126, 3437-3447 (1999).
Depositor相賀 裕美子(国立遺伝学研究所)
Strain Status凍結胚のアイコン凍結胚
Strain Availability凍結精子より作出したマウスを2~4ヶ月以内に提供可能
Additional Info.Genotyping protocol -PCR-
Mouse of the Month Feb 2006
Genetic Background
Saga Lab HP

BRC mice in Publications

MacDonald ST, Bamforth SD, Chen CM, Farthing CR, Franklyn A, Broadbent C, Schneider JE, Saga Y, Lewandoski M, Bhattacharya S.
Epiblastic Cited2 deficiency results in cardiac phenotypic heterogeneity and provides a mechanism for haploinsufficiency.
Cardiovasc. Res. 79(3) 448-57(2008) 18440989

Lindsley RC, Gill JG, Murphy TL, Langer EM, Cai M, Mashayekhi M, Wang W, Niwa N, Nerbonne JM, Kyba M, Murphy KM.
Mesp1 coordinately regulates cardiovascular fate restriction and epithelial-mesenchymal transition in differentiating ESCs.
Cell Stem Cell 3(1) 55-68(2008) 18593559

Thompson H, Ohazama A, Sharpe PT, Tucker AS.
The origin of the stapes and relationship to the otic capsule and oval window.
Dev. Dyn. 241(9) 1396-404(2012) 22778034

Rothova M, Thompson H, Lickert H, Tucker AS.
Lineage tracing of the endoderm during oral development.
Dev. Dyn. (2012) 22581563

Randall V, McCue K, Roberts C, Kyriakopoulou V, Beddow S, Barrett AN, Vitelli F, Prescott K, Shaw-Smith C, Devriendt K, Bosman E, Steffes G, Steel KP, Simrick S, Basson MA, Illingworth E, Scambler PJ.
Great vessel development requires biallelic expression of Chd7 and Tbx1 in pharyngeal ectoderm in mice.
J. Clin. Invest. 119(11) 510518(2009) 19855134

Dominguez-Frutos, E., Vendrell, V., Alvarez, Y., Zelarayan, L.C., Lopez-Hernandez, I., Ros, M. and Schimmang, T.
Tissue-specific requirements for FGF8 during early inner ear development.
Mech. Dev. 126(10) 873-81(2009) 19619645