Strain Data Sheet

RBRC01143

Strain Information

Image
BRC No.RBRC01143
TypeTransgeneCartagena
SpeciesMus musculus
Strain nameICR.Cg-Tg(CAG-cat,-Dll1)1Ysa/YsaRbrc
Former Common nameCAG-CAT-Delta1
H-2 Haplotype
ES Cell line
Background strainICR MCH
Appearancealbino [c/c]
Strain developmentDeveloped by Dr. Yumiko Saga (2002). The transgene fragment was injected into the pronucleous of B6C3F1 fertilized eggs. This strain were maintained under ICR background.
Strain descriptionDll1, delta-like 1 (Drosophila) is one of Notch ligands. This transgenic mouse expresses the Dll1 gene after mating with a cre transgenic mouse. This strain is useful for elucidation of the Notch-signalling mechanism underlying initial segmentation in the presomitic mesoderm.
Colony maintenanceSibling Mating
References

Health Report

Examination Date / Room / Rack2023/11/06Room:2-検Rack:C
2023/08/07Room:2-検Rack:C

Gene

Gene SymbolGene NameChr.Allele SymbolAllele NameCommon NamesPromoterDiseases Related to This Gene
signal pep13
  • neurodevelopmental disorder with nonspecific brain abnormalities and with or without seizures(MedGEN)
    • Dll1delta like canonical Notch ligand 113Dll1
  • neurodevelopmental disorder with nonspecific brain abnormalities and with or without seizures(MedGEN)
    • catE. coli chloramphenicol acetyltransferase (CAT)13CAG promoter (CMV-IE enhancer, chicken beta-actin promoter, rabbit beta-globin genomic DNA)
  • neurodevelopmental disorder with nonspecific brain abnormalities and with or without seizures(MedGEN)
    • loxPphage P1 loxP13loxP
  • neurodevelopmental disorder with nonspecific brain abnormalities and with or without seizures(MedGEN)
    • loxPphage P1 loxP13loxP
  • neurodevelopmental disorder with nonspecific brain abnormalities and with or without seizures(MedGEN)
    • myc-tagmyc-epitope tag13myc-tag
  • neurodevelopmental disorder with nonspecific brain abnormalities and with or without seizures(MedGEN)

    • Phenotype

    Annotation by Mammalian phenotyhpe ontology
  • obsolete no phenotypic analysis(MP:0003012)
    • Detailed phenotype data

    Ordering Information

    Donor DNACAG promoter (CMV-IE enhancer, chicken beta-actin promoter, rabbit beta-globin genomic DNA), phage P1 loxP sites, E. coli chloramphenicol acetyltransferase (CAT) gene, poly A, signal peptide, myc-tag, Delta1 cDNA
    Research applicationCre/loxP system
    Specific Term and ConditionsIn publishing the research results to be obtained by use of the BIOLOGICAL RESOURCE, an acknowledgment to the DEPOSITOR is requested.
    DepositorYumiko Saga (National Institute of Genetics)
    Strain Statusan icon for Frozen embryosFrozen embryos
    an icon for Frozen spermFrozen sperm
    Strain AvailabilityRecovered litters from cryopreserved embryos (2 to 4 months)
    Cryopreserved sperm (within 1 month)
    Cryopreserved embryos (within 1 month)
    Additional Info.Necessary documents for ordering:
    1. Order form (Japanese / English)
    2. Category I MTA: MTA for distribution with RIKEN BRC (Japanese / English)
    3. CAGGS MTA (English)
    4. Acceptance of responsibility for living modified organism (Japanese / English)
    Saga Lab HP
    Genotyping protocol -PCR-

    BRC mice in Publications

    Kratsios P, Catela C, Salimova E, Huth M, Berno V, Rosenthal N, Mourkioti F.
    Distinct roles for cell-autonomous Notch signaling in cardiomyocytes of the embryonic and adult heart.
    Circ Res 106(3) 559-72(2010) 20007915