Strain Data Sheet

RBRC01136

Strain Information

Image
BRC No.RBRC01136
TypeTransgene and Chromosomal AberrationCartagena
SpeciesMus musculus
Strain nameB6.Cg-Dspd/Rbrc
Former Common nameDspd mouse
H-2 Haplotype
ES Cell line
Background strain
Appearance
Strain development
Strain description
Colony maintenance
References
The novel dominant mutation Dspd leads to a severe spermiogenesis defect in mice.
Kai M, Irie M, Okutsu T, Inoue K, Ogonuki N, Miki H, Yokoyama M, Migishima R, Muguruma K, Fujimura H, Kohda T, Ogura A, Kaneko-Ishino T, Ishino F
Biol. Reprod., 70, 1213-1221 (2004). 14695912

Health Report

Examination Date / Room / Rack

Gene

Gene SymbolGene NameChr.Allele SymbolAllele NameCommon NamesPromoterDiseases Related to This Gene
Dspddominant spermiogenesis defect14DspdCAG promoter (CMV-IE enhancer, chicken beta-actin promoter, rabbit beta-globin genomic DNA)
Dspddominant spermiogenesis defect7DspdCAG promoter (CMV-IE enhancer, chicken beta-actin promoter, rabbit beta-globin genomic DNA)

Phenotype

Annotation by Mammalian phenotyhpe ontology
  • abnormal sperm head morphology(MP:0009230)

  • abnormal spermiogenesis(MP:0001932)

  • male infertility(MP:0001925)

  • oligozoospermia(MP:0002687)

  • reduced female fertility(MP:0001923)
    • Detailed phenotype data

    Ordering Information

    Donor DNAhuman PEG8/IGF2 cDNA, CAG promoter (CMV-IE enhancer, chicken beta-actin promoter, rabbit beta-globin genomic DNA)
    Research applicationReproductive Biology Research
    Specific Term and ConditionsThe RECIPIENT of BIOLOGICAL RESOURCE shall obtain a prior written consent on use of it from the DEPOSITOR.
    DepositorFumitoshi Ishino (Tokyo Medical and Dental University)
    Strain Statusan icon for Frozen embryosFrozen embryos
    Strain AvailabilityRecovery and QC required prior to distribution
    Additional Info.Necessary documents for ordering:
    1. Approval form (Japanese / English)
    2. Order form (Japanese / English)
    3. Category I MTA: MTA for distribution with RIKEN BRC (Japanese / English)
    4. CAGGS MTA (English)
    5. Acceptance of responsibility for living modified organism (Japanese / English)
    Lab HP (Japanese)
    Genotyping protocol -PCR-

    BRC mice in Publications

    No Data