Strain Information | |
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Image | |
BRC No. | RBRC01121 |
Type | Targeted Mutation |
Species | Mus musculus |
Strain name | B6.Cg-Ren1<tm1Afu>/AfuRbrc |
Former Common name | REN-KO (BL/6) |
H-2 Haplotype | |
ES Cell line | TT2 [(C57BL/6NCrlj x CBA/JNCrlj)F1] |
Background strain | C57BL/6JJcl |
Appearance | |
Strain development | Developed by Dr. Keiji Tanimoto, University of Tsukuba in 2003. C57BL/6 background. |
Strain description | B6.Cg-Ren1<tm1Afu>. Renin plays an essential role in the control of blood pressure through its specific leavage of angiotensinogen to generate angiotensin I. Homozygous mutant mice exhibit lowered blood pressure, increased urine and drinking volume, and altered renal morphology. |
Colony maintenance | Sibling Mating (Heterozygote x Heterozygote, Wild-type) Homozygous mutant mice lowered blood pressure and die within a week after birth. |
References | Renin-dependent cardiovascular functions and renin-independent blood-brain barrier functions revealed by renin-deficient mice. Yanai K, Saito T, Kakinuma Y, Kon Y, Hirota K, Taniguchi-Yanai K, Nishijo N, Shigematsu Y, Horiguchi H, Kasuya Y, Sugiyama F, Yagami K i, Murakami K, Fukamizu A J. Biol. Chem., 275, 5-8 (2000). 10617578 |
Health Report | |
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Examination Date / Room / Rack |
Gene | |||||||
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Gene Symbol | Gene Name | Chr. | Allele Symbol | Allele Name | Common Names | Promoter | Diseases Related to This Gene |
Ren1 | renin 1 structural | 1 | Ren1 | targeted mutation 1, Akiyoshi Fukamizu | |||
lacZ | beta-galactosidase (E. coli) | 1 | |||||
neo | neomycin resistance gene (E. coli) | 1 |
Phenotype | |
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Annotation by Mammalian phenotyhpe ontology | more 11 phenotypes |
Detailed phenotype data |
Ordering Information | |
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Donor DNA | mouse renin 1 genomic DNA, E. coli neo, E. coli lacZ |
Research application | Cell Biology Research Hematological Research |
Specific Term and Conditions | The RECIPIENT of BIOLOGICAL RESOURCE shall obtain a prior written consent on use of it from the DEPOSITOR. In publishing the research results obtained by use of the BIOLOGICAL RESOURCE, a citation of the following literature(s) designated by the DEPOSITOR is requested. J. Biol. Chem., 275, 5-8 (2000). |
Depositor | Akiyoshi Fukamizu (University of Tsukuba) |
Strain Status | Frozen embryos Frozen sperm |
Strain Availability | Recovered litters from cryopreserved embryos (2 to 4 months) Cryopreserved sperm (within 1 month) Cryopreserved embryos (within 1 month) |
Additional Info. | Necessary documents for ordering:
Genotyping protocol -PCR- |
BRC mice in Publications |
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No Data |