Strain Data Sheet

RBRC01118

Strain Information

Image
BRC No.RBRC01118
TypeTargeted MutationCartagena
SpeciesMus musculus
Strain nameICR.Cg-Agt<tm1Afu>/AfuRbrc
Former Common nameAGT-KO (ICR)
H-2 Haplotype
ES Cell lineTT2 [(C57BL/6NCrlj x CBA/JNCrlj)F1]
Background strainICR
Appearance
Strain development開発年：2003年開発者：谷本啓司先生機関名：筑波大学ICR(チャールズ）　5〜6代
Strain description内在のアンジオテンシノーゲン遺伝子を欠損し、低血圧を呈する。
Colony maintenanceInbred Strain をback groundとした場合には特にhomo化した場合に繁殖が困難。本系統はoutbred の ICR をbackgroundとするため少なくともheteroで維持する限りにおいて問題は認められない。ホモ化した場合、〜50％死亡する可能性あり。
References
Angiotensinogen-deficient mice with hypotension.
K Tanimoto, F Sugiyama, Y Goto, J Ishida, E Takimoto, K Yagami, A Fukamizu, K Murakami
J. Biol. Chem., 269, 31334-31337 (1994). 7989296

Health Report

Examination Date / Room / Rack

Gene

Gene SymbolGene NameChr.Allele SymbolAllele NameCommon NamesPromoterDiseases Related to This Gene
Agt
MGI:87963		angiotensinogen8Agt<tm1Afu>
MGI:2136636		targeted mutation 1, Akiyoshi Fukamizu
  • essential hypertension, genetic(MedGEN)

  • renal tubular dysgenesis of genetic origin(MedGEN)
    • neo neomycin resistance gene (E. coli)8

    Phenotype

    Phenotype annotation from literatures by Mammalian phenotype ontology
  • abnormal blood homeostasis (MP:0009642)

  • abnormal blood-brain barrier function (MP:0005167)

  • abnormal enzyme/coenzyme level (MP:0005319)

  • abnormal hippocampus granule cell layer (MP:0008285)

  • abnormal juxtaglomerular apparatus morphology (MP:0002829)
    • more 38 phenotypes
  • abnormal kidney afferent arteriole morphology (MP:0011312)

  • abnormal kidney inner medulla morphology (MP:0011333)

  • abnormal kidney interlobular artery morphology (MP:0011316)

  • abnormal kidney morphology (MP:0002135)

  • abnormal kidney vasculature morphology (MP:0000530)

  • decreased body size (MP:0001265)

  • decreased body weight (MP:0001262)

  • decreased circulating aldosterone level (MP:0002667)

  • decreased circulating angiotensinogen level (MP:0006376)

  • decreased creatinine clearance (MP:0005558)

  • decreased epididymal fat pad weight (MP:0009289)

  • decreased fat cell size (MP:0009269)

  • decreased renal glomerulus number (MP:0004505)

  • decreased systemic arterial blood pressure (MP:0002843)

  • decreased systemic arterial diastolic blood pressure (MP:0006263)

  • decreased systemic arterial systolic blood pressure (MP:0006264)

  • decreased total body fat amount (MP:0010025)

  • decreased urine aldosterone level (MP:0011541)

  • decreased urine osmolality (MP:0002988)

  • decreased urine potassium level (MP:0005618)

  • decreased urine sodium level (MP:0006317)

  • hydronephrosis (MP:0000519)

  • hypotension (MP:0001596)

  • impaired blood-brain barrier function (MP:0031384)

  • increased circulating antidiuretic hormone level (MP:0005610)

  • increased circulating renin level (MP:0003352)

  • increased kidney weight (MP:0003917)

  • increased locomotor activity (MP:0031391)

  • increased urine antidiuretic hormone level (MP:0011543)

  • kidney medulla atrophy (MP:0011422)

  • kidney papillary atrophy (MP:0011304)

  • polydipsia (MP:0001426)

  • polyuria (MP:0001762)

  • postnatal lethality, incomplete penetrance (MP:0011086)

  • renal tubule atrophy (MP:0011346)

  • slow postnatal weight gain (MP:0008489)

  • tubulointerstitial nephritis (MP:0011405)

  • vascular smooth muscle hyperplasia (MP:0005489)
    • Detailed phenotype data

    Ordering Information

    供与核酸mouse angiotensinogen genomic DNA, E. coli neo
    Research applicationCell Biology Research
    Hematological Research
    covid19_onset
    提供条件利用者は事前に寄託者の提供承諾書を得る。研究成果の公表にあたって寄託者の指定する文献を引用する。J. Biol. Chem., 269, 31334-31337 (1994).
    Depositor深水　昭吉（国立大学法人筑波大学）
    Strain Status凍結胚のアイコン凍結胚
    凍結精子のアイコン凍結精子
    Strain Availability凍結胚より作出したマウスを2~4ヶ月以内に提供可能
    凍結精子を1ヶ月以内に提供可能
    凍結胚を1ヶ月以内に提供可能
    Additional Info.Necessary documents for ordering:
    1. Approval form (Japanese / English)
    2. Order form (Japanese / English)
    3. Category I MTA: MTA for distribution with RIKEN BRC (Japanese / English)
    4. Acceptance of responsibility for living modified organism (Japanese / English)
    Lab HP (Japanese)

    BRC mice in Publications

    No Data