Strain Data Sheet

RBRC01118

Strain Information

Image
BRC No.RBRC01118
TypeTargeted MutationCartagena
SpeciesMus musculus
Strain nameICR.Cg-Agt<tm1Afu>/AfuRbrc
Former Common nameAGT-KO (ICR)
H-2 Haplotype
ES Cell lineTT2 [(C57BL/6NCrlj x CBA/JNCrlj)F1]
Background strainICR
Appearance
Strain development
Strain description
Colony maintenance
References
Angiotensinogen-deficient mice with hypotension.
Tanimoto K, Sugiyama F, Goto Y, Ishida J, Takimoto E, Yagami K, Fukamizu A, Murakami K
J. Biol. Chem., 269, 31334-31337 (1994). 7989296

Health Report

Examination Date / Room / Rack

Gene

Gene SymbolGene NameChr.Allele SymbolAllele NameCommon NamesPromoterDiseases Related to This Gene
Agtangiotensinogen8Agttargeted mutation 1, Akiyoshi Fukamizu
  • essential hypertension, genetic(MedGEN)

  • renal tubular dysgenesis of genetic origin(MedGEN)
  • neoneomycin resistance gene (E. coli)8
  • essential hypertension, genetic(MedGEN)

  • renal tubular dysgenesis of genetic origin(MedGEN)
  • Phenotype

    Annotation by Mammalian phenotyhpe ontology
  • abnormal blood homeostasis(MP:0009642)

  • abnormal blood-brain barrier function(MP:0005167)

  • abnormal enzyme/coenzyme level(MP:0005319)

  • abnormal hippocampus granule cell layer(MP:0008285)

  • abnormal juxtaglomerular apparatus morphology(MP:0002829)
  • more 38 phenotypes
  • abnormal kidney afferent arteriole morphology(MP:0011312)

  • abnormal kidney inner medulla morphology(MP:0011333)

  • abnormal kidney interlobular artery morphology(MP:0011316)

  • abnormal kidney morphology(MP:0002135)

  • abnormal kidney vasculature morphology(MP:0000530)

  • decreased body size(MP:0001265)

  • decreased body weight(MP:0001262)

  • decreased circulating aldosterone level(MP:0002667)

  • decreased circulating angiotensinogen level(MP:0006376)

  • decreased creatinine clearance(MP:0005558)

  • decreased epididymal fat pad weight(MP:0009289)

  • decreased fat cell size(MP:0009269)

  • decreased renal glomerulus number(MP:0004505)

  • decreased systemic arterial blood pressure(MP:0002843)

  • decreased systemic arterial diastolic blood pressure(MP:0006263)

  • decreased systemic arterial systolic blood pressure(MP:0006264)

  • decreased total body fat amount(MP:0010025)

  • decreased urine aldosterone level(MP:0011541)

  • decreased urine osmolality(MP:0002988)

  • decreased urine potassium level(MP:0005618)

  • decreased urine sodium level(MP:0006317)

  • hydronephrosis(MP:0000519)

  • hyperactivity(MP:0001399)

  • hypertension(MP:0000231)

  • hypotension(MP:0001596)

  • increased circulating antidiuretic hormone level(MP:0005610)

  • increased circulating renin level(MP:0003352)

  • increased kidney weight(MP:0003917)

  • increased urine antidiuretic hormone level(MP:0011543)

  • kidney medulla atrophy(MP:0011422)

  • kidney papillary atrophy(MP:0011304)

  • polydipsia(MP:0001426)

  • polyuria(MP:0001762)

  • postnatal lethality, incomplete penetrance(MP:0011086)

  • renal tubule atrophy(MP:0011346)

  • slow postnatal weight gain(MP:0008489)

  • tubulointerstitial nephritis(MP:0011405)

  • vascular smooth muscle hyperplasia(MP:0005489)
  • Detailed phenotype data

    Ordering Information

    Donor DNAmouse angiotensinogen genomic DNA, E. coli neo
    Research applicationCell Biology Research
    Hematological Research
    covid19_onset
    Specific Term and ConditionsThe RECIPIENT of BIOLOGICAL RESOURCE shall obtain a prior written consent on use of it from the DEPOSITOR. In publishing the research results obtained by use of the BIOLOGICAL RESOURCE, a citation of the following literature(s) designated by the DEPOSITOR is requested. J. Biol. Chem., 269, 31334-31337 (1994).
    DepositorAkiyoshi Fukamizu (University of Tsukuba)
    Strain Statusan icon for Frozen embryosFrozen embryos
    an icon for Frozen spermFrozen sperm
    Strain AvailabilityRecovered litters from cryopreserved embryos (2 to 4 months)
    Cryopreserved sperm (within 1 month)
    Cryopreserved embryos (within 1 month)
    Additional Info.Necessary documents for ordering:
    1. Approval form (Japanese / English)
    2. Order form (Japanese / English)
    3. Category I MTA: MTA for distribution with RIKEN BRC (Japanese / English)
    4. Acceptance of responsibility for living modified organism (Japanese / English)
    Lab HP (Japanese)

    BRC mice in Publications

    No Data