Strain Information | |
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Image | |
BRC No. | RBRC01106 |
Type | Targeted Mutation |
Species | Mus musculus |
Strain name | ICR.Cg-Sema3a<tm1.2Tyag>/TyagRbrc |
Former Common name | semaphorin III/D (conditional) Targeting mice |
H-2 Haplotype | |
ES Cell line | TT2 [(C57BL/6NCrlj x CBA/JNCrlj)F1] |
Background strain | Jcl:ICR |
Appearance | albino [c/c] |
Strain development | Developed by Masahiko Taniguchi and Takeshi Yagi, National Institute for Physiological Sciences in 1997. TT2 ES cells were used. ICR mixed background. |
Strain description | Semaphorin III/D (Sema3a) floxed mice Homozygous mutant mice are viable and fertile. |
Colony maintenance | Homozygote x Homozygote [or Crossing to Jcl:ICR] |
References | Disruption of semaphorin III/D gene causes severe abnormality in peripheral nerve projection. Taniguchi M, Yuasa S, Fujisawa H, Naruse I, Saga S, Mishina M, Yagi T Neuron, 19, 519-530 (1997). 9331345 |
Health Report | |
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Examination Date / Room / Rack |
Gene | |||||||
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Gene Symbol | Gene Name | Chr. | Allele Symbol | Allele Name | Common Names | Promoter | Diseases Related to This Gene |
Sema3a | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A | 5 | Sema3a | targeted mutation 1.2, Takeshi Yagi | |||
loxP | phage P1 loxP | 5 | loxP | ||||
loxP | phage P1 loxP | 5 | loxP |
Phenotype | |
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Annotation by Mammalian phenotyhpe ontology | |
Detailed phenotype data |
Ordering Information | |
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Donor DNA | phage P1 loxP sites, mouse semaphorin 3A genomic DNA |
Research application | Cre/loxP system Neurobiology Research |
Specific Term and Conditions | The RECIPIENT of BIOLOGICAL RESOURCE shall obtain a prior written consent on use of it from the DEPOSITOR. In publishing the research results obtained by use of the BIOLOGICAL RESOURCE, a citation of the following literature(s) designated by the DEPOSITOR is requested. Neuron, 19, 519-530 (1997). Any patent rights and other intellectual properties are retained by the depositor. Users have to contact the depositor in the case of application for any patents with the result from these mice. When users releases research results that obtained in two years after deposition, users should contact a bailor about collaboration. |
Depositor | Takeshi Yagi (National Institute for Physiological Sciences) |
Strain Status | Frozen embryos Frozen sperm |
Strain Availability | Recovered litters from cryopreserved embryos (2 to 4 months) Cryopreserved sperm (within 1 month) Cryopreserved embryos (within 1 month) |
Additional Info. | Necessary documents for ordering:
Genotyping protocol -PCR- Mouse of the Month Aug 2006 |
BRC mice in Publications |
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Huang S, Gao D, Li Z, He H, Yu X, You X, Wu D, Du Z, Zeng J, Shi X, Hu Q, Nie Y, Zhang Z, Luo Z, Wang D, Zhao Z, Li L, Wang G, Wang L, Zhou Z, Chen D, Yang F. Neuronal guidance factor Sema3A inhibits neurite ingrowth and prevents chondrocyte hypertrophy in the degeneration of knee cartilage in mice, monkeys and humans. Bone Res 13(1) 4(2025) 39746903 |
Hayashi M, Nakashima T, Yoshimura N, Okamoto K, Tanaka S, Takayanagi H. Autoregulation of Osteocyte Sema3A Orchestrates Estrogen Action and Counteracts Bone Aging. Cell Metab 29(3) 627-637.e5(2019) 30661929 |
Fukuda T, Takeda S, Xu R, Ochi H, Sunamura S, Sato T, Shibata S, Yoshida Y, Gu Z, Kimura A, Ma C, Xu C, Bando W, Fujita K, Shinomiya K, Hirai T, Asou Y, Enomoto M, Okano H, Okawa A, Itoh H. Sema3A regulates bone-mass accrual through sensory innervations. Nature 497(7450) 490-3(2013) 23644455 |
Zhou J, Wen Y, She L, Sui YN, Liu L, Richards LJ, Poo MM. Axon position within the corpus callosum determines contralateral cortical projection. Proc Natl Acad Sci U S A 110(29) E2714-23(2013) 23812756 |
Imai T, Yamazaki T, Kobayakawa R, Kobayakawa K, Abe T, Suzuki M, Sakano H. Pre-target axon sorting establishes the neural map topography. Science 325(5940) 585-90(2009) 19589963 |
Shadrach JL, Pierchala BA. Semaphorin3A Signaling Is Dispensable for Motor Axon Reinnervation of the Adult Neuromuscular Junction. eNeuro 5(3) (2018) 29774231 |