Strain Data Sheet

RBRC01073

Strain Information

Image
BRC No.RBRC01073
TypeCongenic
SpeciesMus musculus
Strain nameSM.A-(D2Mit295-D2Mit281)/Rbrc
Former Common nameSM.A-t2dm2sa
H-2 Haplotype
ES Cell line
Background strain
Appearance
Strain developmentDeveloped by Drs. Misato Kobayashi and Fumihiko Horio, Graduate School of Bioagricultural Sciences, Nagoya University in 2003. This SM.A-t2dm2sa congenic strain was produced by 6 backcrossing of the region between D2Mit295 to D2Mit281 of A/J onto the SM/J.
Strain descriptionThis strain carries diabetes-related loci from Chr 2 of A/J backcrossed to SM/J. This strain is useful for helping to understand of the complex gene-gene interaction and model of human type 2 diabetes. This SM.A-t2dm2sa congenic strain was produced by 6 backcrossing of the region between D2Mit295 to D2Mit281 of A/J onto the SM/J.
Colony maintenance
References
Combinations of nondiabetic parental genomes elicit impaired glucose tolerance in mouse SMXA recombinant inbred strains.
Kobayashi M, Ohno T, Tsuji A, Nishimura M, Horio F
Diabetes, 52, 180-186 (2003). 12502510

Major quantitative trait locus on chromosome 2 for glucose tolerance in diabetic SMXA-5 mouse established from non-diabetic SM/J and A/J strains.
Kobayashi M, Io F, Kawai T, Kumazawa M, Ikegami H, Nishimura M, Ohno T, Horio F
Diabetologia, 49(3):486-495 (2006). 16447060

Quantitative trait loci for impaired glucose tolerance in nondiabetic SM/J and A/J mice.
Hada N, Kobayashi M, Fujiyoshi M, Ishikawa A, Kuga M, Nishimura M, Ebihara S, Ohno T, Horio F
Physiol Genomics, 35(1): 65-74 (2008). 18628340

Health Report

Examination Date / Room / Rack

Gene

Gene SymbolGene NameChr.Allele SymbolAllele NameCommon NamesPromoterDiseases Related to This Gene
t2dm2sa type 2 diabetes mellitus 22t2dm2sa<A/J>

Phenotype

Annotation by Mammalian phenotyhpe ontology
  • abnormal nursing(MP:0001382)

  • impaired glucose tolerance(MP:0005293)

  • increased body mass index(MP:0006087)

  • increased body weight(MP:0001260)

  • increased circulating glucose level(MP:0005559)
    • more 2 phenotypes
  • increased circulating insulin level(MP:0002079)

  • increased total body fat amount(MP:0010024)
    • Detailed phenotype data

    Ordering Information

    Donor DNA
    Research applicationDiabetes and Obesity Research
    covid19_progression
    Specific Term and ConditionsThe RECIPIENT of BIOLOGICAL RESOURCE shall obtain a prior written consent on use of it from the DEPOSITOR. In publishing the research results obtained by use of the BIOLOGICAL RESOURCE, a citation of the following literature(s) designated by the DEPOSITOR is requested. Diabetologia, 49,486-495 (2006). In publishing the research results to be obtained by use of the BIOLOGICAL RESOURCE, an acknowledgment to the DEPOSITOR is requested. The RECIPIENT must contact the DEPOSITOR in the case of application for any patents or commercial use based on the results from the use of the BIOLOGICAL RESOURCE.The RECIPIENT agrees to use this BIOLOGICAL RESOURCE as a collaboration with the DEPOSITOR.
    DepositorFumihiko Horio (Nagoya University)
    Strain Statusan icon for Frozen embryosFrozen embryos
    Strain AvailabilityRecovered litters from cryopreserved embryos (2 to 4 months)
    Cryopreserved embryos (within 1 month)
    Additional Info.Necessary documents for ordering:
    1. Approval form (Japanese / English)
    2. Order form (Japanese / English)
    3. Category I MTA: MTA for distribution with RIKEN BRC (Japanese / English)
    Lab HP (Japanese)

    BRC mice in Publications

    No Data