Strain Data Sheet

O'Hara J, Dakle P, Nguyen MLT, Barugahare A, Bennett TJ, Udupa VA, Murray N, Schlegel G, Kapouleas C, Li J, Turner SJ, Russ BE.
Notch dependent chromatin remodeling enables Gata3 binding and drives lineage specific CD8+ T cell function.
Immunol Cell Biol (2025) 40012375

Chen KY, Kibayashi T, Giguelay A, Hata M, Nakajima S, Mikami N, Takeshima Y, Ichiyama K, Omiya R, Ludwig LS, Hattori K, Sakaguchi S.
Genome-wide CRISPR screen in human T cells reveals regulators of FOXP3.
Nature (2025) 40140585

Lingamallu SM, Deshpande A, Joy N, Ganeshan K, Ray N, Ladher RK, Taketo MM, Lafkas D, Guha A.
Neuroepithelial bodies and terminal bronchioles are niches for distinctive club cells that repair the airways following acute notch inhibition.
Cell Rep 43(9) 114654(2024) 39182223

Shi Z, Xiong S, Hu R, Wang Z, Park J, Qian Y, Wang J, Bhalla P, Velupally N, Song Q, Song Z, Jeon MS, Zhang KK, Xie L, Layden BT, Ong SG, Jiang Y.
The Notch-PDGFRβ axis suppresses brown adipocyte progenitor differentiation in early post-natal mice.
Dev Cell 59(10) 1233-1251.e5(2024) 38569546

Canalis E, Yu J, Singh V, Mocarska M, Schilling L.
NOTCH2 sensitizes the chondrocyte to the inflammatory response of tumor necrosis factor α.
J Biol Chem 299(12) 105372(2023) 37865314

Iga T, Kobayashi H, Kusumoto D, Sanosaka T, Fujita N, Tai-Nagara I, Ando T, Takahashi T, Matsuo K, Hozumi K, Ito K, Ema M, Miyamoto T, Matsumoto M, Nakamura M, Okano H, Shibata S, Kohyama J, Kim KK, Takubo K, Kubota Y.
Spatial heterogeneity of bone marrow endothelial cells unveils a distinct subtype in the epiphysis.
Nat Cell Biol 25(10) 1415-1425(2023) 37798545

Pu W, Zhu H, Zhang M, Pikiolek M, Ercan C, Li J, Huang X, Han X, Zhang Z, Lv Z, Li Y, Liu K, He L, Liu X, Heim MH, Terracciano LM, Tchorz JS, Zhou B.
Bipotent transitional liver progenitor cells contribute to liver regeneration.
Nat Genet 55(4) 651-664(2023) 36914834

Fleig S, Kapanadze T, Bernier-Latmani J, Lill JK, Wyss T, Gamrekelashvili J, Kijas D, Liu B, Hüsing AM, Bovay E, Jirmo AC, Halle S, Ricke-Hoch M, Adams RH, Engel DR, von Vietinghoff S, Förster R, Hilfiker-Kleiner D, Haller H, Petrova TV, Limbourg FP.
Loss of vascular endothelial notch signaling promotes spontaneous formation of tertiary lymphoid structures.
Nat Commun 13(1) 2022(2022) 35440634

Fujimaki S, Matsumoto T, Muramatsu M, Nagahisa H, Horii N, Seko D, Masuda S, Wang X, Asakura Y, Takahashi Y, Miyamoto Y, Usuki S, Yasunaga KI, Kamei Y, Nishinakamura R, Minami T, Fukuda T, Asakura A, Ono Y.
The endothelial Dll4-muscular Notch2 axis regulates skeletal muscle mass.
Nat Metab 4(2) 180-189(2022) 35228746

Masuda T, Amann L, Monaco G, Sankowski R, Staszewski O, Krueger M, Del Gaudio F, He L, Paterson N, Nent E, Fernández-Klett F, Yamasaki A, Frosch M, Fliegauf M, Bosch LFP, Ulupinar H, Hagemeyer N, Schreiner D, Dorrier C, Tsuda M, Grothe C, Joutel A, Daneman R, Betsholtz C, Lendahl U, Knobeloch KP, Lämmermann T, Priller J, Kierdorf K, Prinz M.
Specification of CNS macrophage subsets occurs postnatally in defined niches.
Nature 604(7907) 740-748(2022) 35444273

Lee S, Remark LH, Josephson AM, Leclerc K, Lopez EM, Kirby DJ, Mehta D, Litwa HP, Wong MZ, Shin SY, Leucht P.
Notch-Wnt signal crosstalk regulates proliferation and differentiation of osteoprogenitor cells during intramembranous bone healing.
NPJ Regen Med 6(1) 29(2021) 34050174

Sawaguchi S, Varshney S, Ogawa M, Sakaidani Y, Yagi H, Takeshita K, Murohara T, Kato K, Sundaram S, Stanley P, Okajima T.
O-GlcNAc on NOTCH1 EGF repeats regulates ligand-induced Notch signaling and vascular development in mammals.
Elife 6 (2017) 28395734

Abravanel DL, Belka GK, Pan TC, Pant DK, Collins MA, Sterner CJ, Chodosh LA.
Notch promotes recurrence of dormant tumor cells following HER2/neu-targeted therapy.
J Clin Invest 125(6) 2484-96(2015) 25961456

Nakamura M, Shibata K, Hatano S, Sato T, Ohkawa Y, Yamada H, Ikuta K, Yoshikai Y.
A genome-wide analysis identifies a notch-RBP-Jκ-IL-7Rα axis that controls IL-17-producing γδ T cell homeostasis in mice.
J Immunol 194(1) 243-51(2015) 25429074

Obata Y, Kimura S, Nakato G, Iizuka K, Miyagawa Y, Nakamura Y, Furusawa Y, Sugiyama M, Suzuki K, Ebisawa M, Fujimura Y, Yoshida H, Iwanaga T, Hase K, Ohno H.
Epithelial-stromal interaction via Notch signaling is essential for the full maturation of gut-associated lymphoid tissues.
EMBO Rep 15(12) 1297-304(2014) 25378482

Hosaka Y, Saito T, Sugita S, Hikata T, Kobayashi H, Fukai A, Taniguchi Y, Hirata M, Akiyama H, Chung UI, Kawaguchi H.
Notch signaling in chondrocytes modulates endochondral ossification and osteoarthritis development.
Proc Natl Acad Sci U S A 110(5) 1875-80(2013) 23319657

Liu Z, Owen T, Fang J, Srinivasan RS, Zuo J.
In vivo Notch reactivation in differentiating cochlear hair cells induces Sox2 and Prox1 expression but does not disrupt hair cell maturation.
Dev Dyn 241(4) 684-96(2012) 22354878

Mead TJ, Yutzey KE.
Notch pathway regulation of neural crest cell development in vivo.
Dev Dyn 241(2) 376-89(2012) 22275227

Obata Y, Takahashi D, Ebisawa M, Kakiguchi K, Yonemura S, Jinnohara T, Kanaya T, Fujimura Y, Ohmae M, Hase K, Ohno H.
Epithelial cell-intrinsic Notch signaling plays an essential role in the maintenance of gut immune homeostasis.
J Immunol 188(5) 2427-36(2012) 22279105

Ito T, Kwon HY, Zimdahl B, Congdon KL, Blum J, Lento WE, Zhao C, Lagoo A, Gerrard G, Foroni L, Goldman J, Goh H, Kim SH, Kim DW, Chuah C, Oehler VG, Radich JP, Jordan CT, Reya T.
Regulation of myeloid leukaemia by the cell-fate determinant Musashi.
Nature 466(7307) 765-8(2010) 20639863

Fujimoto M, Takagi Y, Muraki K, Nozaki K, Yamamoto N, Tsuji M, Hashimoto N, Honjo T, Tanigaki K.
RBP-J promotes neuronal differentiation and inhibits oligodendroglial development in adult neurogenesis.
Dev Biol 332(2) 339-50(2009) 19501584

Zong Y, Panikkar A, Xu J, Antoniou A, Raynaud P, Lemaigre F, Stanger BZ.
Notch signaling controls liver development by regulating biliary differentiation.
Development 136(10) 1727-39(2009) 19369401

Niwa Y, Masamizu Y, Liu T, Nakayama R, Deng CX, Kageyama R.
The initiation and propagation of Hes7 oscillation are cooperatively regulated by Fgf and notch signaling in the somite segmentation clock.
Dev Cell 13(2) 298-304(2007) 17681139