Strain Data Sheet

RBRC01064

Strain Information

Image
BRC No.RBRC01064
TypeInbred
SpeciesMus musculus
Strain nameLgh/NgaRbrc
Former Common nameLgh
H-2 Haplotype
ES Cell line
Background strain
Appearance
Strain developmentDeveloped by Dr. Noboru Wakasugi, School of Agricultural Sciences, Nagoya University in 1995.
Strain descriptionT, Brachyury mutant mice, semidominant. T/T homozygous mutant mice are embryonic lethal. T/+ heterozygous mice show short tail.
Colony maintenance
References

Health Report

Examination Date / Room / Rack

Gene

Gene SymbolGene NameChr.Allele SymbolAllele NameCommon NamesPromoterDiseases Related to This Gene
T
MGI:98472
brachyury, T-box transcription factor T17T<Lgh> lagging hind limbs
  • neural tube defect(MedGEN)

  • sacral agenesis-abnormal ossification of the vertebral bodies-persistent notochordal canal syndrome(MedGEN)
  • Phenotype

    Annotation by Mammalian phenotyhpe ontology
  • abnormal lumbar vertebrae morphology(MP:0003049)

  • abnormal neural tube morphology(MP:0002151)

  • abnormal notochord morphology(MP:0002825)

  • abnormal rostral-caudal body axis extension(MP:0003885)

  • abnormal spinal cord morphology(MP:0000955)
  • more 16 phenotypes
  • abnormal tail bud morphology(MP:0002861)

  • abnormal tail development(MP:0006281)

  • abnormal thoracic vertebrae morphology(MP:0003047)

  • absent caudal vertebrae(MP:0004653)

  • absent sacral vertebrae(MP:0004656)

  • absent tail(MP:0003456)

  • absent vertebrae(MP:0000138)

  • absent vertebral arch(MP:0004603)

  • absent vertebral body(MP:0004668)

  • decreased survivor rate(MP:0008770)

  • meningomyelocele(MP:0009929)

  • notochord degeneration(MP:0004712)

  • perinatal lethality, incomplete penetrance(MP:0011090)

  • reproductive system phenotype(MP:0005389)

  • short tail(MP:0000592)

  • split notochord(MP:0004713)
  • Detailed phenotype data

    Ordering Information

    Donor DNA
    Research application
    Specific Term and ConditionsNo specific terms and conditions. (The DEPOSITOR waives its own rights under any patents, intellectual property, or other proprietary rights with respect to the results to be obtained by use of the BIOLOGICAL RESOURCE.)
    DepositorNoboru Wakasugi (Nagoya University)
    Strain Statusan icon for Frozen embryosFrozen embryos
    an icon for Frozen spermFrozen sperm
    Strain AvailabilityRecovered litters from cryopreserved embryos (2 to 4 months)
    Cryopreserved sperm (within 1 month)
    Cryopreserved embryos (within 1 month)
    Additional Info.Necessary documents for ordering:
    1. Order form (Japanese / English)
    2. Category I MTA: MTA for distribution with RIKEN BRC (Japanese / English)

    BRC mice in Publications

    No Data